Industrial Pharmacy Lab 2: Rheology Part I

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What is the primary purpose of studying the rheological properties of pharmaceutical materials?

To understand the flow properties of materials during the preparation and development of pharmaceutical dosage forms. (correct)

To maintain a consistent flow rate of particles during the filling of tablets and capsules.

To determine the intermolecular forces acting on the surface of powder particles.

To ensure the constant weight of powder reaching the die during tablet compression.

What is the key reason for ensuring a constant flow rate of particles during the filling of tablets and capsules?

To achieve uniform weight of the final products.

To reduce the intermolecular forces acting on the surface of powder particles.

To prevent variations in the amount of granules filled in the die during compression. (correct)

To maintain constant content uniformity and good bioavailability.

What is the primary difference between a freely flowable powder and a non-freely (sticky) flowable powder?

The intermolecular forces acting on the particle surface. (correct)

The bulk density of the powder.

The compressibility of the powder.

The particle size distribution.

Which of the following is a key factor that can reduce the flow rate of powder particles?

Increased Van der Waals forces on the particle surface. Signup and view all the answers

What is the main consequence of having a good flow rate of powder particles during tablet compression?

All of the above. Signup and view all the answers

Which of the following is the MOST important reason for studying the rheological properties of pharmaceutical materials?

To ensure the consistent filling of tablets and capsules. Signup and view all the answers

What is the primary reason why irregular-shaped particles have poor flowability?

Irregular particles have rough surfaces that increase friction between particles. Signup and view all the answers

Which of the following is NOT a factor that reduces the flow rate of powders?

Electrical charge on the particles Signup and view all the answers

What is the relationship between particle size and flow rate, as described in the text?

There is an optimal particle size range for good flowability. Signup and view all the answers

How do frictional (electrostatic) forces affect the flowability of powders?

Frictional forces decrease the flowability of powders. Signup and view all the answers

What is the effect of moisture on the flowability of powders?

Moisture can either improve or reduce the flowability of powders, depending on the amount. Signup and view all the answers

Which of the following statements about the factors affecting the flowability of powders is NOT supported by the text?

Increasing the moisture content of powders always improves their flowability. Signup and view all the answers

Which of the following is NOT a mechanism by which glidants improve powder flowability?

Increasing the moisture content on the particle surface Signup and view all the answers

What is the primary reason for the need to carefully control the concentration of lubricants and glidants?

Their hydrophobic nature can cause stickiness and poor flowability at high concentrations Signup and view all the answers

Which of the following statements about granulation is NOT true?

It increases the flowability of powders by reducing particle surface area Signup and view all the answers

Which of the following is a potential issue with over-drying powders during the drying process?

It can convert granules back into fine powder with poor flowability Signup and view all the answers

Which technique is mentioned in the text for altering particle shape and texture to produce spherical, free-flowing granules?

Spray drying Signup and view all the answers

What is the primary function of lubricants in improving powder flow?

Both reducing friction between particles and between particles and equipment surfaces Signup and view all the answers