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Incretin Hormones and Insulin Secretion Quiz

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Incretin Hormones and Insulin Secretion Quiz

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Questions and Answers

What is the role of Glucagon-like peptide 1 (GLP-1) in insulin secretion?

Increases glucagon secretion

Inhibits insulin secretion

Has no effect on insulin secretion

Stimulates insulin secretion (correct)

Which cells secrete Glucagon-like peptide 1 (GLP-1)?

Beta cells

Intestinal L cells (correct)

Intestinal K cells

Alpha cells

How do incretins like GIP and GLP-1 act on Beta cells?

By inhibiting insulin receptors

By blocking cAMP production

By binding to specific cell surface receptors (correct)

By promoting glucagon release

What effect does cytosolic glutamate derived from Malate Aspartate shuttle have on insulin secretion?

Amplifies insulin release Signup and view all the answers

In an incretin unresponsive insulin-secreting Beta cell line, what is found to be diminished?

Glutamate production Signup and view all the answers

What is the primary mechanism by which dietary amino acids induce insulin secretion?

Incretin-dependent mechanisms Signup and view all the answers

What is the role of the Malate Aspartate shuttle in incretin-induced insulin secretion?

It generates cytosolic glutamate, which amplifies insulin release. Signup and view all the answers

How do the incretin hormones GIP and GLP-1 stimulate insulin secretion from pancreatic beta cells?

By binding to their specific cell surface receptors on beta cells. Signup and view all the answers

What is the effect of diminished cytosolic glutamate production in an incretin unresponsive insulin-secreting beta cell line?

It reduces amplification of insulin secretion. Signup and view all the answers

What is the role of cAMP-Protein Kinase A signaling in incretin-induced insulin secretion?

It mediates the uptake of glutamate into insulin granules. Signup and view all the answers