10 Questions
What is the role of Glucagon-like peptide 1 (GLP-1) in insulin secretion?
Stimulates insulin secretion
Which cells secrete Glucagon-like peptide 1 (GLP-1)?
Intestinal L cells
How do incretins like GIP and GLP-1 act on Beta cells?
By binding to specific cell surface receptors
What effect does cytosolic glutamate derived from Malate Aspartate shuttle have on insulin secretion?
Amplifies insulin release
In an incretin unresponsive insulin-secreting Beta cell line, what is found to be diminished?
Glutamate production
What is the primary mechanism by which dietary amino acids induce insulin secretion?
Incretin-dependent mechanisms
What is the role of the Malate Aspartate shuttle in incretin-induced insulin secretion?
It generates cytosolic glutamate, which amplifies insulin release.
How do the incretin hormones GIP and GLP-1 stimulate insulin secretion from pancreatic beta cells?
By binding to their specific cell surface receptors on beta cells.
What is the effect of diminished cytosolic glutamate production in an incretin unresponsive insulin-secreting beta cell line?
It reduces amplification of insulin secretion.
What is the role of cAMP-Protein Kinase A signaling in incretin-induced insulin secretion?
It mediates the uptake of glutamate into insulin granules.
Test your knowledge on incretin hormones and insulin secretion in response to dietary amino acids and glucose. Learn about Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide 1 (GLP-1) secreted from the gut in response to nutrient ingestion.
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