Podcast
Questions and Answers
Individuals at both age ______ are very susceptible to infection.
Individuals at both age ______ are very susceptible to infection.
extremes
Which of the following occurs as people age, affecting the immune system?
Which of the following occurs as people age, affecting the immune system?
- Enhanced macrophage chemotaxis
- Increased acquired immunity
- Increased neutrophil phagocytosis
- Reduced production of cytokines (correct)
Acquired immunity is more impacted than innate immunity as people age.
Acquired immunity is more impacted than innate immunity as people age.
True (A)
Which components are considered social factors that impact susceptibility to disease?
Which components are considered social factors that impact susceptibility to disease?
What is inflammation?
What is inflammation?
Escaping fluid and phagocytic cells from capillaries due to changes in the endothelial cell layer lining in capillary vessels results in which feature of inflammation?
Escaping fluid and phagocytic cells from capillaries due to changes in the endothelial cell layer lining in capillary vessels results in which feature of inflammation?
Recruitment of phagocytes to the site of injury/infection is facilitated by chemotaxis and ______ clot.
Recruitment of phagocytes to the site of injury/infection is facilitated by chemotaxis and ______ clot.
Malnutrition decreases the frequency of infections, especially among younger age groups.
Malnutrition decreases the frequency of infections, especially among younger age groups.
Which describes how microbes on a host surface play a beneficial role?
Which describes how microbes on a host surface play a beneficial role?
How does Propionibacterium acnes on the skin inhibit gram-positive bacteria?
How does Propionibacterium acnes on the skin inhibit gram-positive bacteria?
Match the following components with their respective roles in the phagocytosis process:
Match the following components with their respective roles in the phagocytosis process:
What is the primary function of TNF (Tumor Necrosis Factor)?
What is the primary function of TNF (Tumor Necrosis Factor)?
Lysozyme, found in tears, sweat, and saliva, facilitates peptidoglycan degradation, targeting the bacterial ______.
Lysozyme, found in tears, sweat, and saliva, facilitates peptidoglycan degradation, targeting the bacterial ______.
Which of the following describes how transferrin and lactoferrin function as a barrier to bacterial infection?
Which of the following describes how transferrin and lactoferrin function as a barrier to bacterial infection?
There is no known pathogen capable of crossing unbroken skin.
There is no known pathogen capable of crossing unbroken skin.
Flashcards
Age and Infection
Age and Infection
Individuals at both age extremes are very susceptible to infection.
Immunosenescence
Immunosenescence
As people age the immune system becomes inefficient. Acquired immunity is more impacted than Innate Immunity.
Genetic Factors
Genetic Factors
Populations differ in disease responses due to genetic variations.
Social Factors
Social Factors
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Nutrition
Nutrition
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Inflammation
Inflammation
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Mechanism of Phagocytosis
Mechanism of Phagocytosis
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Interferons
Interferons
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INF- α & β
INF- α & β
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Cytokine
Cytokine
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Complement System
Complement System
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Classical Pathway Activation
Classical Pathway Activation
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Mucus barriers
Mucus barriers
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Transferrin and Lactoferrin
Transferrin and Lactoferrin
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Innate Host Defenses
Innate Host Defenses
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Study Notes
Proof of the Implicit Function Theorem
- $F: \mathbb{R}^{n+k} \rightarrow \mathbb{R}^{k}$ is a $C^{r}$ map, where $r \geq 1$.
- $F(a,b) = 0$ for some $(a,b) \in \mathbb{R}^{n+k}$, where $a \in \mathbb{R}^{n}$ and $b \in \mathbb{R}^{k}$.
- $\frac{\partial F}{\partial y}(a,b)$ is an invertible $k \times k$ matrix.
- There exists a neighborhood $U$ of $a$ in $\mathbb{R}^{n}$ and a $C^{r}$ map $g: U \rightarrow \mathbb{R}^{k}$ such that $g(a) = b$ and $F(x, g(x)) = 0$ for all $x \in U$.
- $g(x)$ is the unique solution of $F(x,y) = 0$ for $y$ near $b$.
- A map $H: \mathbb{R}^{n+k} \rightarrow \mathbb{R}^{n+k}$ is defined by $H(x,y) = (x, F(x,y))$.
- $DH(a,b)$ is invertible ($H(a,b) = (a,0)$).
- The Inverse Function Theorem ensures the existence of neighborhoods and a $C^{r}$ diffeomorphism $H^{-1}$.
- $H^{-1}(x,z) = (\varphi(x,z), \psi(x,z))$, and $F(x, \psi(x,z)) = z$.
- $g: U \rightarrow \mathbb{R}^{k}$ is defined by $g(x) = \psi(x,0)$.
- For uniqueness, $y = g(x)$ if $F(x,y) = 0$ for some $x \in U$ and $y$ near $b$.
Sard's Theorem
- $f: U \rightarrow \mathbb{R}^{k}$ is a $C^{r}$ map, where $U \subset \mathbb{R}^{n}$ is open and $r \geq \max{n-k+1, 1}$.
- Let $C = {x \in U \mid rank(Df(x)) < k}$.
- $f(C)$ has measure zero in $\mathbb{R}^{k}$.
Immersions and Submersions
- $f: X \rightarrow Y$ is a $C^{\infty}$ map of manifolds.
- An immersion means $df_{x}: T_{x}X \rightarrow T_{f(x)}Y$ is injective for all $x \in X$, implying $\dim X \leq \dim Y$.
- A submersion means $df_{x}: T_{x}X \rightarrow T_{f(x)}Y$ is surjective for all $x \in X$, implying $\dim X \geq \dim Y$.
- For an immersion $f$, there exist charts $(U, \varphi)$ about $x$ and $(V, \psi)$ about $f(x)$ such that $\psi \circ f \circ \varphi^{-1}: \varphi(U) \rightarrow \psi(V)$ is the standard inclusion map, i.e. $(x_{1}, \dots, x_{n}) \mapsto (x_{1}, \dots, x_{n}, 0, \dots, 0)$.
- For a submersion $f$, there exist charts $(U, \varphi)$ about $x$ and $(V, \psi)$ about $f(x)$ such that $\psi \circ f \circ \varphi^{-1}: \varphi(U) \rightarrow \psi(V)$ is the standard projection map, i.e. $(x_{1}, \dots, x_{n}) \mapsto (x_{1}, \dots, x_{k})$.
Time Response
- Represents how a dynamic system's state changes over time when subjected to an input.
- Encompasses transient and steady-state responses.
Time Domain
- Involves analyzing mathematical functions, physical signals, or time series (economic or environmental) with respect to time.
Step Function
- Defined as $r(t) = A u(t)$.
- $A$ is the amplitude, and $u(t)$ is the unit step function.
Ramp Function
- Defined as $r(t) = A t \cdot u(t)$.
- $A$ is the slope of the ramp.
Parabolic Function
- Defined as $r(t) = A t^2/2 \cdot u(t)$.
- $A$ is the amplitude of the parabolic.
Impulse Function
- Defined as $r(t) = A\delta(t)$.
- $A$ is the area, and $\delta(t)$ is the unit impulse function.
Transfer Function
- Defined as $G(s) = \frac{K}{\tau s + 1}$.
- $K$ is the steady-state gain, and $\tau$ is the time constant.
Response to a Step Input
- Characterized by $y(t) = K(1 - e^{-t/\tau})$.
Time Constant ($\tau$)
- It's the time it takes for the response to reach 63.2% of its final value.
Settling Time ($t_s$)
- It is the time required for the step response to reach and stay (settle) within a certain percentage of its final value
- $t_{s, 2%} = 4\tau$
- $t_{s, 5%} = 3\tau$
Transfer Function
- Described by $G(s) = \frac{\omega_n^2}{s^2 + 2\zeta\omega_n s + \omega_n^2}$.
- $\omega_n$ is natural frequency, and $\zeta$ is damping ratio.
Damping Ratio
- $\zeta > 1$ is overdamped
- $\zeta = 1$ is critically damped
- $0 < \zeta < 1$ is underdamped
- $\zeta = 0$ is undamped
Step Input (Underdamped)
- Step response: $y(t) = 1 - \frac{e^{-\zeta\omega_n t}}{\sqrt{1 - \zeta^2}}sin(\omega_d t + \theta)$
- $\omega_d = \omega_n \sqrt{1 - \zeta^2}$ is the damped frequency and $\theta = tan^{-1}(\frac{\sqrt{1 - \zeta^2}}{\zeta})$
Rise Time ($t_r$)
- It is the time required to go from 10% to 90% of the steady-state value
- $t_r \approx \frac{1.8}{\omega_n}$
Peak Time ($t_p$)
- It is the time required to reach the peak/overshoot
- $t_p = \frac{\pi}{\omega_d}$
Max Overshoot ($M_p$)
- It is the maximum peak value of the response curve measured from unity
- $M_p = e^{-\frac{\pi\zeta}{\sqrt{1 - \zeta^2}}}$
Settling Time ($t_s$)
- Time required for the step response to reach and stay (settle) within a certain percentage of its final value
- $t_{s, 2%} = \frac{4}{\zeta\omega_n}$
- $t_{s, 5%} = \frac{3}{\zeta\omega_n}$
Ácidos
- Substances that release hydronium ions ($H_3O^+$) when ionized in an aqueous solution.
- Ex: $HCl + H_2O \longrightarrow H_3O^+ + Cl^-$
Classificação
- Number of ionizable hydrogens: monoacids (like HCl), diacids (like $H_2SO_4$), triacids (like $H_3PO_4$), tetracids (like $H_4[Fe(CN)_6]$).
- Presence of oxygen: hydracids (no O, like HCl) and oxyacids (have O, like $H_2SO_4$).
- Strength:
- Hydracids: Strong (HCl, HBr, HI), moderate (HF), or weak (others).
- Oxyacids: Determined by the difference between the number of oxygen and hydrogen atoms (≥ 2: strong, = 1: moderate, = 0: weak).
- $HClO_4$ is a strong oxyacid: (4 - 1 = 3)
- $HClO_3$ is a strong oxyacid: (3 - 1 = 2)
- $HClO_2$ is a moderate oxyacid: (2 - 1 = 1)
- $HClO$ is a weak oxyacid: (1 - 1 = 0)
- Volatility: Either fixed ($H_2SO_4, H_3PO_4$) or volatile (others).
Bases (or Álcalis)
- Substances that release hydroxide ions ($OH^-$) when dissociated in an aqueous solution.
- Ex: $NaOH \longrightarrow Na^+ + OH^-$
Classificação
- Number of Hydroxides: monobases (NaOH), dibases ($Ca(OH)_2$), tribases ($Al(OH)_3$).
- Solubility: Soluble (alkali metal bases and $NH_4OH$), slightly soluble (alkaline earth metal bases), insoluble (others).
- Strength: Strong (alkali and alkaline earth metal bases), weak (others).
Óxidos
- Binary compounds where oxygen is the most electronegative element.
- Ex: $Na_2O, CO_2$
- $OF_2$ isn't an oxide because fluorine is more electronegative than oxygen.
Classificação
- Ionic Oxides: Formed of metals + O with non-variable oxidation states.
- Ex.: $Na_2O, CaO$
- Molecular Oxides: Formed by a non-metal + O, or variable oxidation states metal + O.
- Ex.: $CO_2, SO_3, Mn_2O_7$
- Amphoteric Oxides: React with acids and bases.
- Ex.: $ZnO, Al_2O_3$
- Neutral or Inert Oxides: Do not react with acids, bases, or water.
- Ex.: $CO, NO, N_2O$
- Peroxides: Contain the $O_2^{2-}$ group.
- Ex.: $H_2O_2, Na_2O_2$
- Superoxides: Contains the $O_2^{-}$ group.
- Ex.: $KO_2$
Heat Treatment Definition
- Process of heating, holding, and cooling a material (usually metal) to obtain desired properties.
Heat Treatment Purposes
- Improve strength and hardness.
- Improve ductility and toughness.
- Relieve internal stresses.
- Refine grain size.
- Improve machinability.
- Improve corrosion resistance.
- Improve electrical and magnetic properties.
Annealing
- Involves heating a material to a specific temperature, holding it for a set time, and then cooling it slowly.
Purposes of Annealing
- Soften metal
- Relieve internal stresses
- Refine grain structure
- Improve ductility and toughness
- Improve machinability
Types of Annealing
- Full Annealing includes heating to austenite range, soaking, and slow furnace cooling.
- Process Annealing includes heating below critical temperature, holding, and air cooling
- Stress Relief Annealing includes heating to low temperature, holding, and slow cooling.
- Spheroidizing includes prolonged heating at a temperature slightly below the critical temperature.
- Normalizing includes heating to austenite range, soaking, and air cooling to improve ductility and toughness.
Hardening
- Processes are enacted to to increase the hardness of a metal.
Types of Hardening
- Case Hardening makes changes to the surface of metal while leaving the core softer
- It includes: Carburizing and Nitriding and Cyaniding
- Quench Hardening comes from heating to austenite range and, quenching in water, oil, or air.
- Precipitation/Age Hardening comes from uniformly dispersed metals in a matrix to increase strength and hardness
Tempering
- Increases the toughness of a metal, usually after it has been hardened through heating it to a temperature below its critical poin, holding it at that temperature, and cooling it.
Cryogenic Treatment
- Improves mechanical properties by cooling materials to very low temperatures (typically below −150 °C or −238 °F) to increase hardness, wear resistance, reduce stress, and improve stability.
Furnace Heat Treatment
- Uses a furnace to heat materials.
- Provides a controlled environment for heat treatment.
Induction Heat Treatment
- Uses electromagnetic induction to heat materials.
- Allows for selective or localized heating.
Laser Heat Treatment
- Uses a laser beam to heat materials.
- Provides precise and rapid heating.
Salt Bath Heat Treatment
- Uses a molten salt bath to heat materials.
- Provides rapid and uniform heating.
Factors Affecting Heat Treatment
- Temperature: The temperature to which the material is heated.
- Time: The length of time the material is held at a specific temperature.
- Cooling Rate: The rate at which the material is cooled.
- Atmosphere: The composition of the surrounding atmosphere during heat treatment.
- Material Composition: The chemical composition of the material being heat-treated.
Applications of Heat Treatment
- Heat treatment is used in Automotive and Aerospace components production
- It's also used in Cutting tools production, Gears and bearings, Fasteners, Dies and molds
Improved mechanical properties and Increased wear resistance
Disadvantages of Heat Treatment
- Can be energy-intensive
- May cause distortion or cracking
- Requires precise control of process parameters
- May alter the surface finish of the material
Definition of Reaction Rate
- It refers to the speed at which a chemical reaction converts reactants into products. It is expressed as the concentration change of a reactant or product per unit time.
Factors Affecting Reaction Rate
- Higher reactant concentrations lead to increased reaction rates.
- Higher temperatures lead to increased reaction rates.
- Increased surface area leads to increased reaction rates.
- Catalysts increase the reaction rate without being consumed.
- Higher pressure leads to increased reaction rates, especially in gaseous reactions.
Definition of Rate Law
- It's an equation relating reaction rate and reactant concentrations.
- General form can $aA + bB \rightarrow cC + dD$, with $\text{Rate} = k[A]^m[B]^n$
- $k$ is the rate constant and $m$ and $n$ are the reaction orders with respect to $A$ and $B$, respectively.
Reaction Order
- Zero Order: Rate is independent of reactant concentration ($m \text{ or } n = 0$).
- First Order: Rate is directly proportional to reactant concentration ($m \text{ or } n = 1$).
- Second Order: Rate is proportional to the square of reactant concentration ($m \text{ or } n = 2$).
Methods for Determining Reaction Order
- Initial Rates Method involves varying the initial concentrations and measure the initial rates.
- Graphical Method relies on plotting concentration vs. time data to determine the order based on the linearity of the graphs.
- Isolation Method involves concentrations of all reactants except one excess. Then, the order is determined with respect to the reactant present in smaller concentration.
Arrhenius Equation
- The Arrhenius equation is the the temperature dependence of the rate constant $k$:
- $k = Ae^{-\frac{E_a}{RT}}$ can be described:
- $k$ is the rate constant, $A$ is the pre-exponential factor, $E_a$ is the activation energy, $R$ is the gas constant $(8.314 , \text{J/mol·K})$
- $T$ is the temperature in Kelvin
Definition of Activation Energy
- Activation energy, $E_a$, is the minimum energy required for a reaction to occur.
Definition of Catalysis
- Catalysis is the process used to increase the rate of a chemical reaction by adding a catalyst, which is not consumed in the reaction.
Types of Catalysis
- Homogeneous Catalysis consists of a catalyst that's in the same phase as reactants.
- Heterogeneous Catalysis consists of a catalyst that's in a different phase from reactants.
- Enzyme Catalysis: Enzymes are biological catalysts that speed up biochemical reactions.
Definition of Reaction Mechanisms
- Rate-Determining Step occurs if there's the slowest step in a reaction mechanism, which determines the overall rate of the reaction
Elementary Reactions
Elementary reactions are single-step reactions that cannot be broken down into simpler steps
Definition of Random Variable
- Function assigning a real number to each outcome in sample space of an experiment.
- Denoted by a capital letter (e.g., $X$); observed value with a small letter (e.g., $x$).
Discrete Random Variable
- Has countable number of values (e.g., defective items).
Continous Random Variable
- Has uncountably infinite number of values (e.g. height, temperature).
Probability Distribution
- List of each value of $X$ and its probability.
- Can be a table, graph, or formula.
- Requirements
- $0 \le P(x) \le 1$ for each $x$
- $\Sigma P(x) = 1$
Cumulative Distribution Function
- $P(X \le x) = \Sigma_{t \le x} P(t)$
- Probability that $X$ has value less than or equal to $x$.
- Sums probabilities up to $x$.
Mean (Expected Value)
- $\mu = E(X) = \Sigma xP(x)$
- Weighted average of possible values.
Variance
- $\sigma^2 = V(X) = \Sigma (x - \mu)^2 P(x) = E(X^2) - \mu^2$
- Measure of spread or dispersion.
- Where $E(X^2) = \Sigma x^2 P(x)$
Standard Deviation
- $\sigma = \sqrt{V(X)}$
- Square root of variance.
Joint Probability Distributions
- $P(X = x, Y = y)$
- Probability of both $X = x$ and $Y = y$.
- Requirements
- $0 \le P(x,y) \le 1$ for each $x$ and $y$
- $\Sigma_x \Sigma_y P(x,y) = 1$
Marginal Probabilility Distributions
- Probability Distribution of single variable alone
- $P_X(x) = \Sigma_y P(x,y)$ is the probability of x alone
- $P_Y(y) = \Sigma_x P(x,y)$ is the probability of y alone
Conditional Probabilility Distributions
- $P(X = x | Y = y) = \frac{P(X = x, Y = y)}{P_Y(y)}$
- $P(Y = y | X = x) = \frac{P(X = x, Y = y)}{P_X(x)}$
- Distribution of x if y is known.
Independent Random Variables
- $P(X = x, Y = y) = P_X(x)P_Y(y)$ for all $x$ and $y$
- $X$ and $Y$ have no effect on each other.
Covariance
- Linear association strength measure
- $Cov(X,Y) = E[(X - \mu_X)(Y - \mu_Y)] = E(XY) - \mu_X \mu_Y$ -- where $\mu_X = E(X)$ and $\mu_Y = E(Y)$ and , $E(XY) = \Sigma_x \Sigma_y xyP(x,y)$
Correlation
- $\rho = Corr(X,Y) = \frac{Cov(X,Y)}{\sigma_X \sigma_Y}$
- Standardized covariance measure.
- $-1 \le \rho \le 1$ is the range
- $Cov(X,Y) = 0$ and $\rho = 0$ if independent
Linear Combinations
- Combination of random variables.
- $E(aX + bY) = aE(X) + bE(Y)$
- $V(aX + bY) = a^2V(X) + b^2V(Y) + 2abCov(X,Y)$
- $V(aX + bY) = a^2V(X) + b^2V(Y)$ for independent random variables
Equations of Stellar Structure:
We must recap the four differential equations governing stellar structure:
- Hydrostatic Equilibrium:
$\frac{dP}{dr} = -\rho g = -\frac{GM_r \rho}{r^2}$ where:
$P(r)$ is the pressure at radius $r$. $ρ(r)$ is the density at radius $r$. $G$ is the gravitational constant. $M_r$ is the mass enclosed within radius $r$.
- Mass Continuity:
$\frac{dM_r}{dr} = 4\pi r^2 \rho$ where:
$M_r$ is the mass enclosed within radius $r$. $ρ(r)$ is the density at radius $r$
- Energy Generation:
$\frac{dL_r}{dr} = 4\pi r^2 \rho \epsilon$ where:
$L_r$ is the luminosity at radius $r$. $ϵ$ is the energy generation rate per unit mass.
-
Energy Transport:
-
Radiative Transport:
$\qquad \frac{dT}{dr} = -\frac{3}{4ac} \frac{\kappa \rho}{T^3} \frac{L_r}{4\pi r^2}$
-
Convective Transport:
$\qquad \frac{dT}{dr} = \frac{T}{P} \frac{dP}{dr} \frac{\Gamma - 1}{\Gamma}$
Where also need:
-
An Equation of State (EOS): $P = P(\rho, T, X_i)$
-
Opacity: $\kappa = \kappa (\rho, T, X_i)$
-
Energy Generation Rate: $\epsilon = \epsilon (\rho, T, X_i)$
Boundary Conditions
It is important to know that to solve these equations, we will need boundary conditions at the center ($r = 0$):
$\qquad M_r = 0, \quad L_r = 0$
At the surface ($r = R_*$):
$\qquad T = T_{eff}, \quad L_r = L_$: However, also take into considerations that we don't know $R_$ initially so we can't directly apply the surface boundary conditions.
Surface Boundary Condition Problem
We approximate the surface boundary conditions using a model atmosphere:
-
Photosphere: The thin layer near the surface where photons escape.
-
Optical Depth: $\tau \equiv \int \kappa \rho dr$ measures the opacity.
-
Approximation: Assume $T(\tau)$ is similar to a gray atmosphere:
$\qquad T^4 (\tau) = T_{eff}^4 \frac{3}{4} (\tau + \frac{2}{3})$
- Surface Condition: At the surface ($\tau \approx 0$):
$\qquad T(\tau = 0) = T_{eff} = (\frac{L_}{4\pi R_^2 \sigma})^{1/4} \qquad T(\tau = 0) = T_{eff} = (\frac{L_}{4\pi R_^2 \sigma})^{1/4} $
Solving the Equations
The Process comes down to:
- Guess $L_$, $R_$, and $X_i$ (composition).
- Use the surface boundary conditions to get $T$ and $\rho$ at the surface.
- Integrate inwards using the four differential equations until you reach the center ($r = 0$).
- Check if the central boundary conditions ($M_r = 0$, $L_r = 0$) are satisfied.
- Adjust $L_$ and $R_$ and repeat until all boundary conditions are met.
Example: The Sun
-
Observational Constraints are:*
-
Mass: $M_\odot = 1.989 \times 10^{30} \text{ kg}$
-
Radius: $R_\odot = 6.955 \times 10^8 \text{ m}$
-
Luminosity: $L_\odot = 3.846 \times 10^{26} \text{ W}$
-
Age: $t_\odot = 4.57 \times 10^9 \text{ years}$
-
Surface Composition: Mostly Hydrogen and Helium, with a metallicity of $Z \approx 0.02$
A successful solar model should reproduce these observed parameters.
Central Conditions:
-
$\qquad T_c \approx 1.57 \times 10^7 \text{ K} $
-
$\qquad \rho_c \approx 1.527 \times 10^5 \text{ kg/m}^3$
Composition: Initial composition of $X = 0.706, Y = 0.274 and Z = 0.020$
Energy Transport: Outer Layers Convection becomes important in the outer layers. Core is where Energy is generated by nuclear fusion and is transported radiatively.
The Vogt-Russell Theorem
The mass and chemical composition of a star uniquely determine its radius, luminosity, and internal structure. This theorem however:
- Neglects the effects of rotation and magnetic fields, which can influence stellar structure
- Must be aware that stars can lose mass over time, changing their structure.
- Only applies to stars in hydrostatic and thermal equilibrium otherwise it does not apply to stars undergoing rapid changes.
Initialization
- Set the distance to infinity for every node.
- Set the distance to zero for the starting node $s$.
- Insert all nodes into the priority queue by the following format $Q$ with the priority for the node $v= a[v]$.
Main Loop
While $Q$ is not empty.
- Take node $u$ of the lowest distance from $Q$
- Repeat through each neighbour $v$ of $u$:
- Alternative distance $alt = d[u] + Length (u, v)$.
- Whenever $alt < d[v]$:
- $d[v] = alt$. Then, update the priority node.
Explanation
- The function finds all shortest paths from starting $s$ to nodes in a graphs.
- Efficient through a priority queue to find the shortest distance node.
- Distance d[v] is the memory for the shortest path found to $s$ to $v$.
Example
Is of the following components: A, B, C, D, E and their edge weights. Starting at node A
Edge | Weight |
---|---|
A -> B | 4 |
A -> C | 2 |
B -> C | 1 |
B -> D | 5 |
C -> B | 3 |
C -> D | 7 |
C -> E | 10 |
D -> E | 2 |
Pricing Approaches
Cost-Plus Pricing
- Adds a standard markup to the product's cost, ignoring demand and competition.
Break-Even Analysis and Target Profit Pricing
- Sets prices to break even on the costs or to achieve a target profit.
$$ \text{Break-even point in units} = \frac{\text{Fixed costs}}{\text{Price - Variable costs}} $$
Value-Based Pricing
- Uses buyers' perceptions of value.
- Customer driven.
Competition-Based Pricing
- Sets prices based on competitors' strategies, costs, prices, and market offerings.
New Product Pricing Strategies
Price Skimming
- Sets a high initial price to maximize revenue from segments willing to pay more.
- Requires high product quality, enough buyers, manageable production costs, and difficulty for competitors to undercut prices.
Market Penetration Pricing
- Sets a low initial price to attract many buyers and gain market share.
- Needs price-sensitive market, decreasing production costs with sales volume, and competitive advantage through low prices.
Product Mix Pricing Strategies
Product Line Pricing
- Sets price steps between products in a line based on cost differences and customer evaluations, while keeping competitors' prices in mind.
Optional-Product Pricing
- Includes the pricing of optional or accessory products sold with a main item.
Captive-Product Pricing
- Prices necessary companion products for a main item (e.g., razor blades for a razor).
By-Product Pricing
- Sets prices on by-products to make the main product more competitive.
Product Bundle Pricing
- Offers several products together at a reduced price.
Price Adjustment Strategies
Discount and Allowance Pricing
- Rewards customers for certain responses, like early payments.
Segmented Pricing
- Sells products/services at different prices not based on cost differences.
Psychological Pricing
- Uses prices to suggest product qualities, affecting buyers' psychology.
Promotional Pricing
- Temporarily prices products below list price to boost sales.
Geographical Pricing
- Adjusts prices for different locations.
Dynamic Pricing
- Changes prices continually to meet customer needs and circumstances.
International Pricing
- Adapts prices for international markets.
Scalars
- Characterized by a positive or negative number.
- Examples: length, area, volume, mass, time, temperature
Vectors
- A quantity that has both magnitude and direction
- Examples: position, force, moment
Scalar operations
- Multiplication and Division of a Vector by a Scalar
- The magnitude of the vector changes.
- The direction of the vector is the same, unless the scalar is negative, in which case the direction is opposite.
Vector Additions:
- Triangle Rule:
- "Tip-to-tail" addition
- The resultant vector R extends from the tail of A to the tip of B.
- Parallelogram Law:
- The tail of A and B are at the same point
- A parallelogram is formed by drawing lines parallel to A and B
- The resultant R extends from the tails of A and B to the intersection of the lines parallel to A and B.
Vector Subtraction:
- R = A - B = A + (-B)
- The negative sign reverses the direction of the vector
- $R = \sqrt{A^2 + B^2 - 2AB\cos(c)}$ - is used for the magnitude of two forces
- $\frac{B}{\sin(a)} = \frac{A}{\sin(b)} = \frac{R}{\sin(c)}$ - is used for the direction of the resultant
Finding Components of a Force: A force can be resolved into two components. The parallelogram law is used to determine the components.
Cartesian Vector Notation
A cartesian direction is right-handed coordinate system.
- Unit vectors i, j, k are dimensionless vectors with a magnitude of 1, pointing in the positive x, y, and z directions, respectively.
- F = $F_x$**i** + $F_y$**j** + $F_z$**k** is the resulting force vector
- Magnitude of F = $\sqrt{F_x^2 + F_y^2 + F_z^2}$ is the description of the resulting magnitude of the force vector
- Direction of F is defined by the coordinate direction angles $\alpha$, $\beta$, and $\gamma$.
- $F_x = F\cos(\alpha)$
- $F_y = F\cos(\beta)$
- $F_z = F\cos(\gamma)$
- $\cos^2(\alpha) + \cos^2(\beta) + \cos^2(\gamma) = 1$- is the resulting formula for Directional Cosines
- The formula u = $\frac{F_x}{F}$i + $\frac{F_y}{F}$j + $\frac{F_z}{F}$k = $\cos(\alpha)$i + $\cos(\beta)$j + $\cos(\gamma)$k is the formula for Unit Vector
Addition/Subtraction of Cartesian Vectors
- R* = $\sum$F = $\sum F_x$i + $\sum F_y$j + $\sum F_z$k
Position Vectors
- A position vector r is defined as a fixed vector which locates a point in space relative to another point
- r goes from point A to point B: r = $(x_B - x_A)$i + $(y_B - y_A)$j + $(z_B - z_A)$k
FDL to a Line
- F* = Fu = $F\frac{\mathbf{r}}{r} = F\frac{(x_B - x_A)\mathbf{i} + (y_B - y_A)\mathbf{j} + (z_B - z_A)\mathbf{k}}{\sqrt{(x_B - x_A)^2 + (y_B - y_A)^2 + (z_B - z_A)^2}}$
Dot Operations
- A$\cdot$B = $AB\cos(\theta)$
- A$\cdot$B = $(A_x$**i** + $A_y$**j** + $A_z$**k**)$\cdot$($B_x$**i** + $B_y$**j** + $B_z$**k**) = $A_xB_x + A_yB_y + A_zB_z$
Applications of Dot Operation
-
$\cos(\theta) = \frac{\mathbf{A}\cdot\mathbf{B}}{AB} = \frac{A_xB_x + A_yB_y + A_zB_z}{AB}$- is the formula to solve for the Angle between two vectors
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$A_{a} = A\cos(\theta) = \mathbf{A}\cdot\mathbf{u}$ And $\mathbf{A}_a = (\mathbf{A}\cdot\mathbf{u})\mathbf{u}$- are the formulas to solve for the Component of a vector in a specified direction.
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