Immunotherapy Approaches for Cancer Treatment
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Questions and Answers

what are the 4 types of immonotherapy approaches for cancer treatment

adoptive cellular therapy, targetted antibodies, vaccine therapy and immunomodulators

what are modified tumour cells?

modified tumour cells that are taken out of a patient, modified to make them more sensitive and responsive to the immune system then put back into the body

what some are examples of therapeutic vaccines

modified tumour cells, tumour-associated antigens, dendritic cells and oncolytic viruses

what are some examples of immune system modulators

<p>cytokines (eg.IL-2) and interferons</p> Signup and view all the answers

what are monoclonal antibodies?

<p>targets on tumour cells (eg. CD20 on B cell lymphomas)</p> Signup and view all the answers

give examples of adoptive T-cell transfer?

<p>tumour-infiltrating T cells, peripheral T cells, CART T cells</p> Signup and view all the answers

what do immune checkpoint inhibitors do?

<p>take the breaks off the immune system</p> Signup and view all the answers

how do dendritic cell vaccines work?

<p>dendritic cells are taken from the patient and treated with either peptides or lysate from tumour antigens then put back into the patient</p> Signup and view all the answers

what are the steps of dendritic cell vaccination

<ol> <li>blood is collected</li> <li>isolation of dendritic cell precursors (monocytes)</li> <li>maturation of dendritic cells that have tumour cell antigens</li> <li>administration</li> <li>this stimulates lymphocytes to kill cancer cells</li> </ol> Signup and view all the answers

what are the antitumour effects of cytokines and interferons

<p>direct growth inhibition, enhanced cytotoxic activity of lymphocytes and myeloid cells</p> Signup and view all the answers

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