Podcast
Questions and Answers
Which drug directly inhibits the action of IL-5?
Which drug directly inhibits the action of IL-5?
- Mepolizumab (correct)
- Ustekinumab
- Tocilizumab
- Adalimumab
A patient with severe plaque psoriasis and psoriatic arthritis may benefit from a medication targeting which of the following?
A patient with severe plaque psoriasis and psoriatic arthritis may benefit from a medication targeting which of the following?
- IL-4 receptor
- IL-12/IL-23 (correct)
- TNFα
- H1 and H2 receptors
Which of the following drugs is classified as a selective COX-2 inhibitor?
Which of the following drugs is classified as a selective COX-2 inhibitor?
- Naproxen
- Ibuprofen
- Celecoxib (correct)
- Aspirin
A patient experiencing allergic rhinitis might be prescribed a medication that targets?
A patient experiencing allergic rhinitis might be prescribed a medication that targets?
Which drug is known to inhibit IgE, and is primarily used for allergy-related asthma?
Which drug is known to inhibit IgE, and is primarily used for allergy-related asthma?
Which of the following medications is used to treat both ulcerative colitis and Crohn's disease by targeting the immune cell adhesion/trafficking?
Which of the following medications is used to treat both ulcerative colitis and Crohn's disease by targeting the immune cell adhesion/trafficking?
Which of the following targets is associated with the use of corticosteroids?
Which of the following targets is associated with the use of corticosteroids?
Which of the following drugs is known to target the IL-6 receptor?
Which of the following drugs is known to target the IL-6 receptor?
A patient diagnosed with rheumatoid arthritis (RA) and is prescribed Tofacitinib. What is the target of this medication?
A patient diagnosed with rheumatoid arthritis (RA) and is prescribed Tofacitinib. What is the target of this medication?
Which of the following drugs is used to treat myelofibrosis, graft vs. host disease, and other conditions by targeting JAK1 & JAK2?
Which of the following drugs is used to treat myelofibrosis, graft vs. host disease, and other conditions by targeting JAK1 & JAK2?
Flashcards
Arachidonic Acid Cascade drugs
Arachidonic Acid Cascade drugs
Drugs that target the arachidonic acid cascade.
Antihistamines
Antihistamines
Block H1 and H2 receptors.
NSAIDs
NSAIDs
Block COX-1 and COX-2 enzymes to reduce inflammation, pain, and fever; examples include Aspirin, Ibuprofen, and Naproxen.
Selective NSAIDs
Selective NSAIDs
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montelukast (Singulair)
montelukast (Singulair)
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Anakinra (Keneret)
Anakinra (Keneret)
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Adalimumab (Humira)
Adalimumab (Humira)
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Tocilizumab (Actemra)
Tocilizumab (Actemra)
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Ustekinumab (Stelara)
Ustekinumab (Stelara)
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Omalizumab (Xolair)
Omalizumab (Xolair)
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Study Notes
- Corticosteroids target NFκB and PLA-2 and are used for numerous diseases.
- Antihistamines target H1 and H2 receptors and are used for numerous diseases.
- NSAIDs like Aspirin, Ibuprofen, Naproxen, and Diclofenac target COX-1 and COX-2 for broad inflammation, pain, and fever relief.
- Selective NSAIDs such as Celecoxib (Celebrex) and Etoricoxib target COX-2 for COX-2-specific inflammation and pain.
- Zileuton (Zyflo) targets 5-LOX for asthma treatment.
- Montelukast (Singulair) targets LTRAs for asthma and allergic rhinitis treatment.
- Zafirlukast (Accolate) targets LTRAs for asthma treatment.
Cytokine/cytokine receptor/cytokine pathway drugs
- Anakinra (Keneret) targets the IL-1 receptor for rheumatoid arthritis (RA) treatment.
- Adalimumab (Humira) targets TNFα for RA and psoriasis treatment.
- Tocilizumab (Actemra) targets the IL-6 receptor for RA and systemic juvenile idiopathic arthritis (sJIA) treatment.
- Ustekinumab (Stelara) targets IL-12/IL-23 for Crohn's disease and psoriasis.
- Risankizumab (Skyrizi) targets IL-23A for plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis.
- Mepolizumab (Nucala) targets IL-5 for eosinophilic asthma.
- Dupilumab (Dupixent) targets the IL-4 receptor for eczema.
- Tofacitinib (Xeljanz) targets pan-JAK inhibitor for RA and ulcerative colitis.
- Upadacitinib (Rinvoq) targets Jak1 for RA and ulcerative colitis, and ankylosing spondylitis.
- Ruxolitinib (Opzelura) targets Jak1 & Jak2 for myelofibrosis, graft vs. host disease, atopic dermatitis, and vitiligo.
Immune cell adhesion/trafficking drugs
- Vedolizumab (Entyvio) targets LPAM-1 (α4β7 integrin) for ulcerative colitis and Crohn's disease.
- Natalizumab (Tysabri) targets VLA-1 (α4β1 integrin) for multiple sclerosis and Crohn's disease.
Specific Antibody Isotype inhibitor
- Omalizumab (Xolair) targets IgE for allergy-related asthma.
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