Questions and Answers
Which cells target intracellularly infected cells and activate macrophages to become microbicidal?
CD4 Th1 cells
Which cells do not require co-stimulation and bind tightly to target cells for a long time to release effector molecules directly to the target cell?
Effector T cells
Which cells induce target cells to undergo programmed cell death and release cytotoxic effector proteins contained in their granules?
Cytotoxic CD8 T cells
Which cells are particularly important for acting on macrophages and B cells that have taken up antigen but may not be expressing co-stimulatory molecules?
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Which cells are armed with effector molecules and have activation requirements different from naïve T cells?
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Which cells play a role in inhibiting viral replication and increasing MHC1?
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Which cells target cells infected intracellularly and are hidden from the effects of antibodies and cytotoxic CD8 T cells?
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Which cells release IFNg to inhibit viral replication and increase MHC1, in addition to inducing programmed cell death in target cells?
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Which cells require 2 signals to activate macrophages to become microbicidal?
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Which cells are involved in delivering signals like IFNg and a sensitizing signal to activate macrophages to become microbicidal?
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Which cells play a role in inhibiting viral replication and increasing MHC1, in addition to inducing programmed cell death in target cells?
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Which cells induce target cells to undergo apoptosis and release cytotoxic effector proteins contained in their granules?
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Study Notes
Cellular Interactions
- Cells that target intracellularly infected cells and activate macrophages to become microbicidal are CD4+ T cells (Th1 cells).
- CD4+ T cells do not require co-stimulation and bind tightly to target cells for a long time to release effector molecules directly to the target cell.
Effector Functions
- CD8+ T cells induce target cells to undergo programmed cell death (apoptosis) and release cytotoxic effector proteins contained in their granules.
- Armed CD8+ T cells have activation requirements different from naïve T cells.
Macrophage Activation
- CD4+ T cells are particularly important for acting on macrophages and B cells that have taken up antigen but may not be expressing co-stimulatory molecules.
- CD4+ T cells require 2 signals to activate macrophages to become microbicidal.
- CD4+ T cells are involved in delivering signals like IFNg and a sensitizing signal to activate macrophages to become microbicidal.
Anti-Viral Mechanisms
- CD4+ T cells release IFNg to inhibit viral replication and increase MHC1, in addition to inducing programmed cell death in target cells.
- CD8+ T cells play a role in inhibiting viral replication and increasing MHC1, in addition to inducing programmed cell death in target cells.
Targeting Intracellular Infections
- CD8+ T cells target cells infected intracellularly and are hidden from the effects of antibodies and cytotoxic CD8 T cells.
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