Immunology Quiz

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Questions and Answers

Which cells target intracellularly infected cells and activate macrophages to become microbicidal?

  • Dendritic cells
  • CD4 Th1 cells (correct)
  • T helper cells
  • CD8 cytotoxic T cells

Which cells do not require co-stimulation and bind tightly to target cells for a long time to release effector molecules directly to the target cell?

  • Dendritic cells
  • Cytotoxic CD8 T cells
  • Effector T cells (correct)
  • T helper cells

Which cells induce target cells to undergo programmed cell death and release cytotoxic effector proteins contained in their granules?

  • Effector T cells
  • Cytotoxic CD8 T cells (correct)
  • T helper cells
  • Dendritic cells

Which cells are particularly important for acting on macrophages and B cells that have taken up antigen but may not be expressing co-stimulatory molecules?

<p>CD4 T cells (C)</p> Signup and view all the answers

Which cells are armed with effector molecules and have activation requirements different from naïve T cells?

<p>Effector T cells (A)</p> Signup and view all the answers

Which cells play a role in inhibiting viral replication and increasing MHC1?

<p>Cytotoxic CD8 T cells (D)</p> Signup and view all the answers

Which cells target cells infected intracellularly and are hidden from the effects of antibodies and cytotoxic CD8 T cells?

<p>CD4 Th1 cells (A)</p> Signup and view all the answers

Which cells release IFNg to inhibit viral replication and increase MHC1, in addition to inducing programmed cell death in target cells?

<p>Cytotoxic CD8 T cells (C)</p> Signup and view all the answers

Which cells require 2 signals to activate macrophages to become microbicidal?

<p>CD4 Th1 cells (C)</p> Signup and view all the answers

Which cells are involved in delivering signals like IFNg and a sensitizing signal to activate macrophages to become microbicidal?

<p>CD4 Th1 cells (A)</p> Signup and view all the answers

Which cells play a role in inhibiting viral replication and increasing MHC1, in addition to inducing programmed cell death in target cells?

<p>Cytotoxic CD8 T cells (A)</p> Signup and view all the answers

Which cells induce target cells to undergo apoptosis and release cytotoxic effector proteins contained in their granules?

<p>Cytotoxic CD8 T cells (C)</p> Signup and view all the answers

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Study Notes

Cellular Interactions

  • Cells that target intracellularly infected cells and activate macrophages to become microbicidal are CD4+ T cells (Th1 cells).
  • CD4+ T cells do not require co-stimulation and bind tightly to target cells for a long time to release effector molecules directly to the target cell.

Effector Functions

  • CD8+ T cells induce target cells to undergo programmed cell death (apoptosis) and release cytotoxic effector proteins contained in their granules.
  • Armed CD8+ T cells have activation requirements different from naïve T cells.

Macrophage Activation

  • CD4+ T cells are particularly important for acting on macrophages and B cells that have taken up antigen but may not be expressing co-stimulatory molecules.
  • CD4+ T cells require 2 signals to activate macrophages to become microbicidal.
  • CD4+ T cells are involved in delivering signals like IFNg and a sensitizing signal to activate macrophages to become microbicidal.

Anti-Viral Mechanisms

  • CD4+ T cells release IFNg to inhibit viral replication and increase MHC1, in addition to inducing programmed cell death in target cells.
  • CD8+ T cells play a role in inhibiting viral replication and increasing MHC1, in addition to inducing programmed cell death in target cells.

Targeting Intracellular Infections

  • CD8+ T cells target cells infected intracellularly and are hidden from the effects of antibodies and cytotoxic CD8 T cells.

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