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Questions and Answers
Which of the following is NOT a component of innate immunity?
The process by which T cells learn to distinguish self from non-self antigens in the thymus is called:
Which type of immune cell is primarily responsible for antibody production?
What is the main function of Major Histocompatibility Complex (MHC) II molecules?
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Which of the following is NOT a characteristic of adaptive immunity?
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Neutrophils are primarily involved in:
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The process by which lymphocytes capable of responding to a specific antigen proliferate is called:
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Which of the following is NOT a type of professional antigen-presenting cell?
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The primary function of helper T cells is to:
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Which of the following best describes the function of cytotoxic T cells?
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The ability of the immune system to respond more quickly and effectively to a pathogen it has encountered before is due to:
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Which of the following is NOT a function of the lymphatic system?
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Interferons are classified as:
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Which of the following cells does NOT perform phagocytosis?
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The type of immunity obtained during a lifetime is called:
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Which of the following is an example of a recombinant vaccine?
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IgM antibodies are primarily:
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Monocytes differentiate into:
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Which of the following is NOT a characteristic of IgG antibodies?
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The process of diapedesis refers to:
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Which of the following is NOT a function of the complement system?
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The theory of clonal selection states that:
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Which of the following is NOT a characteristic of a good vaccine?
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The process by which macrophages engulf and destroy pathogens is called:
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Which of the following is NOT a function of antibodies?
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The primary site of T cell maturation is:
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Which of the following best describes the function of regulatory T cells?
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The process of somatic hypermutation occurs in:
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Which of the following is NOT a characteristic of a secondary immune response?
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The main function of the spleen in the immune system is:
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Which of the following is NOT a function of dendritic cells?
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The process by which B cells undergo class switching to produce different antibody isotypes is called:
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Which of the following is NOT a characteristic of innate immunity?
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The main function of natural killer (NK) cells is:
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Which of the following is NOT a type of hypersensitivity reaction?
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The process by which antigens are broken down into peptides for presentation on MHC molecules is called:
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Which of the following is NOT a characteristic of autoimmune diseases?
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The primary function of follicular dendritic cells is:
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Which of the following is NOT a function of cytokines?
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The process by which neutrophils release DNA and proteins to form extracellular traps is called:
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Which of the following is NOT a characteristic of IgA antibodies?
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The primary function of the thymus in the immune system is:
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Which of the following is NOT a function of the complement system?
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The process by which T cells become activated upon encounter with their specific antigen is called:
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Which of the following is NOT a characteristic of immunological tolerance?
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The primary function of eosinophils in the immune system is:
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Which of the following is NOT a characteristic of MHC class I molecules?
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The process by which memory B cells rapidly differentiate into antibody-secreting plasma cells upon re-exposure to an antigen is called:
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Which of the following is NOT a function of the acute phase response?
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The primary function of invariant natural killer T (iNKT) cells is:
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Study Notes
Innate Immunity
- Innate immunity is the first line of defense against pathogens.
- It is non-specific, meaning it does not target specific pathogens.
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Components of innate immunity:
- Physical barriers: skin, mucous membranes, cilia
- Complement system: a group of proteins that can lyse pathogens
- Phagocytes: cells that engulf and destroy pathogens (neutrophils, macrophages)
Adaptive Immunity
- Adaptive immunity is the specific immune response that develops after exposure to a pathogen.
- It is specific, meaning it targets specific pathogens.
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Components of adaptive immunity:
- Lymphocytes: B cells and T cells
- Antibodies: proteins produced by B cells that bind to and neutralize pathogens
- Memory: ability to remember past exposures to pathogens and mount a faster and stronger response upon re-exposure
The Immune System: Cells and Processes
- T cells mature in the thymus and are responsible for cell-mediated immunity.
- B cells mature in the bone marrow and are responsible for humoral immunity (antibody production).
- Thymic education is the process by which T cells learn to distinguish self from non-self antigens.
- Clonal selection is the process by which lymphocytes capable of responding to a specific antigen proliferate.
Major Histocompatibility Complex (MHC)
- MHC I molecules present antigens to CD8+ T cells (cytotoxic T cells).
- MHC II molecules present antigens to CD4+ T cells (helper T cells).
Antigen-Presenting Cells (APCs)
- APCs are cells that present antigens to lymphocytes, activating them.
- Professional APCs include dendritic cells, macrophages, and B cells.
Immune System Cells and Their Functions
- Neutrophils are the most abundant white blood cells and are involved in phagocytosis of pathogens.
- Macrophages are phagocytic cells that also present antigens to T cells.
- Dendritic cells are specialized antigen-presenting cells that activate naive T cells.
- Helper T cells activate and regulate other immune cells, including B cells and cytotoxic T cells.
- Cytotoxic T cells directly kill infected or abnormal cells.
- Regulatory T cells suppress immune responses to prevent autoimmune reactions.
- Natural killer (NK) cells kill virus-infected and tumor cells without prior sensitization.
- Monocytes differentiate into macrophages.
Antibodies and Their Functions
- Antibodies are proteins that bind to and neutralize pathogens.
- IgG is the most abundant antibody in serum, it crosses the placenta and has the longest half-life.
- IgM is the first antibody produced in a primary immune response.
- IgA is the most abundant antibody in secretions and provides mucosal immunity.
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Antibodies can:
- Neutralize toxins: block the activity of toxins produced by pathogens.
- Opsonize pathogens: coat pathogens, making them easier for phagocytes to engulf.
- Activate complement: trigger the complement cascade, which can lyse pathogens.
Lymphatic System
- Lymphatic system is a network of vessels and tissues that transports lymph fluid.
- It is responsible for:
- Transport of lymph: fluid that circulates throughout the body, collecting waste products and transporting immune cells.
- Filtration of pathogens: lymph nodes contain lymphocytes that filter pathogens from lymph fluid.
- Maturation of lymphocytes: lymph nodes and the spleen provide a microenvironment for lymphocyte maturation.
Cytokines
- Cytokines are signaling molecules that regulate immune responses.
- They play a key role in:
- Cell growth and differentiation: regulating the development and function of immune cells.
- Regulation of immune responses: modulating the intensity and duration of immune responses.
- Inflammation: mediating the inflammatory response to infection or injury.
Immune Responses: Primary and Secondary
- Primary immune response: first exposure to a pathogen. It is slower and less effective than the secondary response.
- Secondary immune response: subsequent exposures to the same pathogen. It is faster and more effective due to immunological memory.
- Immunological memory: allows the immune system to respond more quickly and effectively to pathogens it has encountered before.
Vaccines and Their Mechanisms
- Vaccines are biological preparations that provide immunity to a disease.
- Recombinant vaccines are made using genetically engineered pathogens or their components.
Hypersensitivity Reactions
- Hypersensitivity reactions are exaggerated immune responses that can cause tissue damage.
- There are four types:
- Type I (immediate): mediated by IgE antibodies, responsible for allergies.
- Type II (cytotoxic): mediated by IgG or IgM antibodies, responsible for autoimmune diseases.
- Type III (immune complex): mediated by immune complexes, can lead to tissue damage.
- Type IV (delayed): mediated by T cells, responsible for contact dermatitis.
Autoimmune Diseases
- Autoimmune diseases occur when the immune system attacks self-antigens.
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Characteristics:
- Loss of self-tolerance: the immune system fails to recognize and tolerate self-antigens.
- Production of autoantibodies: antibodies that target self-antigens.
- Tissue damage: immune attack on self-antigens can lead to tissue damage.
Immune System Processes and Functions
- Antigen processing: breaking down antigens into peptides for presentation on MHC molecules.
- Antigen presentation: the process of presenting antigens to lymphocytes.
- Diapedesis: the process of white blood cell movement through blood vessel walls into tissues.
- NETosis: the process by which neutrophils release DNA and proteins to form extracellular traps.
- Somatic hypermutation: a mechanism that increases the diversity of antibodies produced by B cells.
- Isotype switching: a process that allows B cells to produce different antibody isotypes.
- Affinity maturation: a process that increases the affinity of antibodies for their antigens.
- Acute phase response: a rapid, non-specific response to infection or injury.
Immune System Organs and Their Functions
- Thymus: primary site of T cell maturation.
- Spleen: filters blood-borne pathogens, stores platelets, and produces lymphocytes.
- Lymph nodes: filter lymph fluid, contain lymphocytes, and provide a microenvironment for lymphocyte maturation.
Immune System Tolerance
- Immunological tolerance: the ability of the immune system to recognize and tolerate self-antigens.
- It is crucial for preventing autoimmune diseases.
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Mechanisms of tolerance:
- Elimination of self-reactive lymphocytes: self-reactive lymphocytes are eliminated during development.
- Induction of regulatory T cells: regulatory T cells suppress immune responses to self-antigens.
Other Immune System Cells and Processes
- Eosinophils: involved in the defense against parasitic infections.
- Invariant natural killer T (iNKT) cells: recognize lipid antigens and play a role in both innate and adaptive immunity.
- Follicular dendritic cells: retain and present antigens to B cells, promoting antibody production.
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Description
Test your knowledge on the components and functions of innate and adaptive immunity. This quiz covers topics such as physical barriers, lymphocytes, and the complement system. Enhance your understanding of the immune system and its crucial role in defending against pathogens.