Immunology Quiz: Adaptive and Innate Cells

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Questions and Answers

What is the primary process for generating immune cells called?

  • Hematopoiesis (correct)
  • Apoptosis
  • Neurogenesis
  • Immunosuppression

Which of the following cells is primarily involved in adaptive immunity?

  • Basophils
  • T-cells (correct)
  • Natural Killer cells
  • Neutrophils

What type of cell is responsible for phagocytosing pathogens?

  • T-cells
  • Monocytes (correct)
  • Basophils
  • B-cells

Which type of immune cell is known for producing antibodies?

<p>B-cells (D)</p> Signup and view all the answers

Which cells play a significant role in both innate and adaptive immunity?

<p>Macrophages (A)</p> Signup and view all the answers

What distinguishes Dendritic cells from other immune cells?

<p>They initiate the immune response by processing antigens. (A)</p> Signup and view all the answers

What is the role of Natural Killer cells in the immune system?

<p>To hunt for and destroy virally infected or tumor cells. (D)</p> Signup and view all the answers

Which of the following cells could be involved in an allergic reaction?

<p>Mast cells (D)</p> Signup and view all the answers

What is the primary role of plasma cells?

<p>To produce and secrete a single antibody type (D)</p> Signup and view all the answers

Where does the majority of B cell activation occur?

<p>In the lymph nodes (C)</p> Signup and view all the answers

What type of T cell is involved in the direct killing of tumor cells?

<p>Cytotoxic T lymphocytes (CD8+ T cells) (C)</p> Signup and view all the answers

What is the function of T helper (TH) cells?

<p>To mediate immune response through cytokine secretion (A)</p> Signup and view all the answers

What happens to activated B cells after their activation?

<p>They migrate around the body and change into plasma cells (B)</p> Signup and view all the answers

Where do memory B cells primarily remain after stimulation?

<p>In the lymph nodes (D)</p> Signup and view all the answers

Which type of T cell is known for its role in down-regulating immune responses?

<p>Cytotoxic T lymphocytes (C)</p> Signup and view all the answers

What triggers B cells to multiply and become active?

<p>Binding of antigens through their receptors (B)</p> Signup and view all the answers

What is the primary function of dendritic cells?

<p>Antigen presenting (A)</p> Signup and view all the answers

Where are dendritic cells primarily located?

<p>Lymphoid organs and bloodstream (C)</p> Signup and view all the answers

What type of immune cell is most abundant in the bloodstream?

<p>Neutrophils (B)</p> Signup and view all the answers

What role do basophils and eosinophils play in the immune response?

<p>Defending against parasites and allergic reactions (D)</p> Signup and view all the answers

Which cells are normally the first to arrive at the site of inflammation?

<p>Neutrophils (B)</p> Signup and view all the answers

What do dendritic cells capture and process in lymphoid organs?

<p>Antigens (D)</p> Signup and view all the answers

During which phase do neutrophils migrate towards the site of infection?

<p>Acute phase (A)</p> Signup and view all the answers

Which type of cell is more efficient as an antigen-presenting cell than macrophages?

<p>Dendritic cells (A)</p> Signup and view all the answers

What is the role of IL-4 in the immune system?

<p>Stimulates B progenitors and mast cell progenitors (D)</p> Signup and view all the answers

Where does B cell maturation take place in humans?

<p>Bone marrow (B)</p> Signup and view all the answers

What type of blood cells do GM-CSF induce the formation of?

<p>Nonlymphoid blood cells (B)</p> Signup and view all the answers

Which interleukin stimulates the production of eosinophil progenitors?

<p>IL-5 (B)</p> Signup and view all the answers

What major function do B cells serve in the immune response?

<p>Antibody production (D)</p> Signup and view all the answers

Which interleukin is responsible for inducing the differentiation of lymphoid progenitor cells into B and T progenitors?

<p>IL-7 (C)</p> Signup and view all the answers

What is the primary role of the innate immune response?

<p>To provide immediate defense against pathogens (C)</p> Signup and view all the answers

What is the primary function of antibodies produced by B cells?

<p>Signal other immune cells to act (A)</p> Signup and view all the answers

Which cells are primarily responsible for antigen presentation in the adaptive immune response?

<p>Macrophages and dendritic cells (A)</p> Signup and view all the answers

Which interleukin stimulates the neutrophil progenitor?

<p>IL-8 (B)</p> Signup and view all the answers

What is a significant consequence of failed apoptosis during hematopoiesis?

<p>Potential development of leukemia (B)</p> Signup and view all the answers

At what stage of embryonic development does hematopoiesis begin in humans?

<p>In the yolk sac within the first weeks (B)</p> Signup and view all the answers

What role do stem cells play in hematopoiesis?

<p>They represent a population of self-renewing cells (C)</p> Signup and view all the answers

What is the average production of blood cells in humans per day?

<p>3.7 hundred billion cells (D)</p> Signup and view all the answers

Which cells are responsible for taking on a wide range of pathogens in the immune system?

<p>Macrophages (C)</p> Signup and view all the answers

When does hematopoiesis shift from the fetal liver and spleen to becoming the major organ in adults?

<p>Between 3-7 months of gestation (A)</p> Signup and view all the answers

What is the primary function of natural killer (NK) cells?

<p>To directly kill tumors and virus-infected cells (A)</p> Signup and view all the answers

What percentage of leukocytes in the human body do monocytes comprise?

<p>2% to 10% (B)</p> Signup and view all the answers

Which role is NOT associated with macrophages?

<p>Producing antibodies (B)</p> Signup and view all the answers

What do monocytes differentiate into after entering major organs?

<p>Macrophages (A)</p> Signup and view all the answers

What is formed during the ingestion of a pathogen by a macrophage?

<p>Phagosome (D)</p> Signup and view all the answers

What initiates the increase in phagocytosis by macrophages?

<p>Stimulation by cytokines (C)</p> Signup and view all the answers

What is the final step in the process of phagocytosis by macrophages?

<p>Expulsion or assimilation of waste material (C)</p> Signup and view all the answers

What do macrophages ingest that triggers the immune response?

<p>Pathogens (D)</p> Signup and view all the answers

Flashcards

Hematopoiesis

The process of generating different blood cells, including immune cells, from stem cells in the bone marrow.

B-cells

A type of white blood cell responsible for adaptive immunity. They mature in the bone marrow and produce antibodies to fight specific pathogens.

T-cells

A type of white blood cell responsible for adaptive immunity. They mature in the thymus and directly attack infected cells or destroy infected cells.

Natural Killer (NK) cells

A type of white blood cell that plays a central role in innate immunity by identifying and destroying infected or cancerous cells without prior exposure to the pathogen.

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Monocytes

A type of white blood cell produced in the bone marrow that migrate to tissues and differentiate into macrophages.

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Macrophages

A type of large phagocytic cell that engulfs and destroys pathogens, cellular debris, and foreign particles. They play a crucial role in both innate and adaptive immunity.

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Dendritic cells

A type of antigen-presenting cell (APC) that captures and presents foreign antigens to other immune cells, triggering adaptive immune responses. They are key players in both innate and adaptive immunity.

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Neutrophils

The most abundant type of white blood cell in the blood. They quickly migrate to sites of infection and engulf and destroy bacteria and other pathogens. They are a key part of the innate immune response.

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What are B-cells?

A type of white blood cell that develops into plasma cells that produce antibodies.

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What is hematopoiesis?

Refers to the process by which stem cells differentiate into various blood cell types, including immune cells.

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What are T-cells?

A type of immune cell that matures in the thymus and directly attacks infected cells or triggers their destruction.

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What are antibodies?

A group of proteins produced by B-cells that recognize and bind to specific antigens.

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What is an antigen?

Any molecule that triggers an immune response, like a virus or bacteria.

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What are Natural Killer (NK) cells?

A type of white blood cell that directly destroys infected or cancerous cells without prior training.

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What are monocytes?

A type of white blood cell that matures into macrophages in tissues.

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What are macrophages?

A type of white blood cell that engulfs and destroys pathogens, cellular debris, and foreign particles.

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What is the innate immune response?

The innate immune response is the body's first line of defense against pathogens. It's quick, non-specific, and involves cells like neutrophils, macrophages, and NK cells.

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What is the adaptive immune response?

The adaptive immune response is a more targeted defense mechanism that takes time to develop. It involves specific recognition of pathogens and uses cells like T cells, B cells, and antigen-presenting cells.

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How does the immune system recognize and fight pathogens?

The immune system has a limited number of cells that can recognize each specific pathogen. When those cells encounter their matching pathogen, they multiply rapidly to fight it off.

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Where does hematopoiesis take place during development?

Hematopoiesis begins in the yolk sac during early embryonic development. During the third month of gestation, it shifts to the fetal liver and spleen. Finally, the bone marrow becomes the primary site for hematopoiesis.

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What are stem cells and what is their role in hematopoiesis?

Stem cells are pluripotent, which means they can differentiate into various blood cell types. They self-renew, ensuring a continuous supply of blood cells throughout life.

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What is apoptosis and its role in hematopoiesis?

Apoptosis is programmed cell death, a critical process for regulating cell numbers during hematopoiesis. Failure of apoptosis can lead to leukemia.

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How is hematopoiesis balanced?

Hematopoiesis is a continuous process that balances cell division and differentiation with apoptosis. This ensures a constant supply of healthy blood cells.

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What are Plasma Cells?

B cells that are responsible for the production and secretion of a single antibody type. They are the key to long-term immunity as they continuously produce antibodies.

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What are Memory B Cells?

These B cells are formed after stimulating a B cell with an antigen. They reside in lymph nodes and are ready to launch a faster and stronger immune response if the same antigen is encountered again.

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What are T Helper (TH) cells?

T helper cells, also known as CD4+ T cells, are critical for immune response coordination. They stimulate B cells to produce antibodies and activate cytotoxic T cells.

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What are Cytotoxic T Lymphocytes (CTLs)?

Cytotoxic T lymphocytes (CTLs) or CD8+ T cells are the 'killers' of the immune system. They directly destroy infected or cancerous cells by releasing toxic substances.

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Where are T cells found?

These cells are found throughout the body, particularly in lymphoid organs like lymph nodes and spleen. They are crucial for controlling and regulating immune responses.

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How do B cells become Plasma Cells?

The process where a B cell is activated, begins to multiply, and eventually becomes a plasma cell.

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What do certain cells in lymph nodes do?

They engulf and present foreign substances (antigens) to B and T cells. This is crucial for triggering adaptive immunity.

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What is the role of T helper cells in adaptive immunity?

They are key players in the adaptive immune response by activating B cells to produce antibodies and cytotoxic T cells to kill infected cells.

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What are dendritic cells?

Dendritic cells are powerful antigen-presenting cells (APCs) that capture and process antigens, initiating immune responses. They are found in lymphoid organs, blood, and tissues.

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What are neutrophils?

Neutrophils are the most abundant type of phagocytes, engulfing and destroying bacteria and other pathogens. They are the 'first responders' at infection sites.

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What are basophils and eosinophils?

Basophils and eosinophils release chemicals that defend against parasites and play a role in allergic reactions. They are related to neutrophils.

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What are antigen presenting cells (APCs)?

Antigen presenting cells (APCs) are immune cells that capture and process antigens and present them to other immune cells, initiating adaptive immune responses.

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What is phagocytosis?

Phagocytosis is a process where certain immune cells engulf and destroy foreign particles, including pathogens. It's one of the primary defenses against infection.

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What are natural killer (NK) cells and how do they differ from Tc cells?

Natural killer (NK) cells are a type of lymphocyte similar to cytotoxic T cells (CD8+ T cells) They directly kill infected or cancerous cells, but unlike CD8+ T cells, they don't need to recognize antigens presented by MHC molecules.

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What are monocytes and what is their role in the immune system?

Monocytes are large white blood cells that differentiate into macrophages. They compose 2%-10% of all leukocytes, and they circulate throughout the body, entering organs like the liver and pancreas. They are involved in both innate and adaptive immune responses.

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What are macrophages and what roles do they play in the immune system?

Macrophages, large phagocytic cells, are crucial players in both innate and adaptive immunity. They engulf and destroy pathogens, cellular debris, and foreign particles. They can act as antigen-presenting cells (APCs) by presenting ingested antigens to T cells and B cells, initiating immune responses.

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What is phagocytosis and how does it work in macrophages?

Phagocytosis is a process where macrophages engulf and engulf pathogens or cellular debris. It occurs in several steps, including the formation of a phagosome, fusion with lysosomes, and finally, digestion and expelling waste.

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What are lysosomes and what role do they play in phagocytosis?

Lysosomes are organelles containing digestive enzymes. In phagocytosis, they fuse with the phagosome, creating a phagolysosome where the enzymes break down the engulfed material.

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What is a phagosome and how is it formed?

A phagosome is a membrane-bound vesicle that forms around a pathogen or debris when a macrophage engulfs it during phagocytosis.

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What happens to the waste material after phagocytosis is complete?

Waste material from the digested pathogen is expelled or assimilated by the macrophage after the phagocytosis process is complete.

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Study Notes

Immunology

  • Subject: Zoology
  • Paper: 10 Immunology
  • Module: 05 Phylogeny and Ontogeny of immune system: Cells of immune system
  • Development Team:
    • Principal Investigator: Prof. Neeta Sehgal, Department of Zoology, University of Delhi
    • Co-Principal Investigator: Prof. D.K. Singh, Department of Zoology, University of Delhi
    • Paper Coordinator: Prof. Anju Shrivastava, Department of Zoology, University of Delhi
    • Content Writer: Dr. Ravi Toteja, Acharya Narendra Dev College, University of Delhi
    • Content Reviewer: Prof. Sukhmahendra Singh, Banaras Hindu University

Learning Objectives

  • Processes of generation of immune cells
  • Various types of cells involved in innate and adaptive immunity
  • Functions of various cell types in generation of immune response

Introduction

  • Immune response to pathogens is coordinated by complex interactions between numerous cell types.
  • Innate immune response is the first line of defense, occurring quickly after pathogen exposure.
  • Phagocytes (neutrophils, macrophages), natural killer (NK) cells, and granulocytes are involved in innate immunity.
  • Adaptive immunity develops over days through antigen-specific mechanisms.
  • Antigen-presenting cells (including macrophages and dendritic cells), T cells, and B cells are crucial components of adaptive immunity.

Hematopoiesis

  • Hematopoiesis is the formation and development of blood cells.
  • It's a continuous process throughout adulthood.
  • The human body produces approximately 3.7 x 10¹¹ blood cells per day.
  • Hematopoiesis is regulated by complex mechanisms, including cell division, differentiation, and apoptosis (programmed cell death).
  • Problems with apoptosis can lead to leukemia.

Immune System Cells

  • B-cells: Account for 10-15% of circulating lymphocytes. They mature in bone marrow and produce antibodies targeting specific antigens for pathogen elimination. A B-cell becomes a plasma cell that releases antibodies into the blood, providing immunity.
  • T-cells: Lymphocytes subdivided into helper T cells (CD4⁺) and cytotoxic T cells (CD8⁺). Helper T cells regulate responses, while cytotoxic T cells directly kill infected or cancerous cells.
  • Natural Killer (NK) cells: Similar to cytotoxic T cells, NK cells directly kill tumor and virus-infected cells without prior antigen recognition.
  • Monocytes: The largest type of white blood cell. They differentiate into macrophages, influencing both innate and adaptive immunity.
  • Macrophages: Function in phagocytosis (engulfing and destroying pathogens) and act as antigen-presenting cells (APCs), initiating adaptive immune responses.
  • Dendritic cells: Efficient antigen-presenting cells, found in lymphoid organs, processing and presenting antigens, initiating immunological responses.
  • Neutrophils: Most abundant phagocytes, crucial during inflammation, migrating to infection sites and engulfing pathogens.
  • Basophils and eosinophils: Involved in defense against parasites and allergic reactions.
  • Mast cells: Found in connective tissue and mucous membranes, involved in inflammatory response, often linked to allergies and anaphylaxis.

Phagocytosis

  • Phagocytes ingest pathogens via phagocytosis.
  • Fusion of lysosomes with phagosomes creates phagolysosomes, where pathogens are broken down.
  • Waste products are expelled.

Dendritic Cells

  • Important antigen-presenting cells.
  • Play a crucial role in initiating immune responses.

Neutrophils

  • Most abundant phagocyte.
  • Critical during inflammatory responses.
  • Usually the first cells to arrive at infection sites.

Basophils and Eosinophils

  • Involved in defense against parasites.
  • Play a role in allergic reactions (like asthma).

Mast Cells

  • Found in connective tissues and mucous membranes.
  • Involved in inflammatory responses.
  • Often associated with allergies and anaphylaxis

Summary

  • Adaptive and innate immune responses rely on diverse cell types.
  • Hematopoiesis is the process of blood cell formation, crucial for immune cell production.
  • Various mechanisms exist to combat pathogens, like phagocytosis and antigen presentation, which involve specialized immune cells.

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