Immunology: Pre-B Cell Development Checkpoints
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Questions and Answers

Which gene segments rearrange first in the development of B-lymphocytes?

  • Heavy and light Ig-chain gene segments
  • V-DJ gene segments
  • RAG-1 and RAG-2 gene segments
  • D-J gene segments (correct)

    • What is the main function of TdT (terminal deoxynucleotidyl transferase) in B-cell development?

  • Synthesizing mIgM
  • Expressing RAG-1 and RAG-2 genes
  • Rearranging gene segments for light Ig-chain
  • Assisting in Ig-rearrangement (correct)

    • What deficiency may lead to severe combined immune deficiency (SCID) due to a lack of mature lymphocytes?

  • Lack of RAG-1 and RAG-2 gene activity
  • Absence of TdT gene expression
  • Failure in V-DJ rearrangement (correct)
  • Rearrangement of light Ig-chain genes

    • In which stage of B-cell development are the rearranged heavy chain gene segments transcribed?

    <p>Large pre-B cell</p> Signup and view all the answers

    What role does the surrogate light chain play in B-cell development?

    <p>Initiation of gene rearrangement</p> Signup and view all the answers

    Which enzyme is essential for the rearrangement of gene segments in B-lymphocyte development?

    <p>Terminal deoxynucleotidyl transferase (TdT)</p> Signup and view all the answers

    What is the first checkpoint in the development of B cells?

    <p>Ig α and Ig β expression</p> Signup and view all the answers

    Which gene mutation leads to X-linked agammaglobulinemia?

    <p>Btk gene mutation</p> Signup and view all the answers

    What is the function of allelic exclusion in B cells?

    <p>Ensures monospecificity of each B cell</p> Signup and view all the answers

    Which protein is a key component of both pre-BCR and BCR signaling?

    <p>Bruton's tyrosine kinase (BTK)</p> Signup and view all the answers

    What occurs when a pre-B cell recognizes self-antigens?

    <p>Elimination by apoptosis</p> Signup and view all the answers

    What is the role of the pre-B cell receptor in B-cell development?

    <p>Checking autoreactivity</p> Signup and view all the answers

    What is the primary immunoglobulin expressed by immature B cells in the bone marrow?

    <p>IgM</p> Signup and view all the answers

    In what stage of B lymphocyte differentiation do immature B cells enter primary lymphoid follicles?

    <p>Maturation stage</p> Signup and view all the answers

    Which receptors are expressed on the surface of a mature, immunocompetent naïve B cell?

    <p>CD19 and CD21</p> Signup and view all the answers

    What is the role of CD19 in B-cell development?

    <p>Enhance BCR signaling</p> Signup and view all the answers

    Which factor contributes to anergy in B-cell clones?

    <p>Failure to respond to self-antigens</p> Signup and view all the answers

    What is the fate of immature B cells that are not self-reactive?

    <p>Leave the bone marrow</p> Signup and view all the answers

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