18 Questions
Which gene segments rearrange first in the development of B-lymphocytes?
D-J gene segments
What is the main function of TdT (terminal deoxynucleotidyl transferase) in B-cell development?
Assisting in Ig-rearrangement
What deficiency may lead to severe combined immune deficiency (SCID) due to a lack of mature lymphocytes?
Failure in V-DJ rearrangement
In which stage of B-cell development are the rearranged heavy chain gene segments transcribed?
Large pre-B cell
What role does the surrogate light chain play in B-cell development?
Initiation of gene rearrangement
Which enzyme is essential for the rearrangement of gene segments in B-lymphocyte development?
Terminal deoxynucleotidyl transferase (TdT)
What is the first checkpoint in the development of B cells?
Ig α and Ig β expression
Which gene mutation leads to X-linked agammaglobulinemia?
Btk gene mutation
What is the function of allelic exclusion in B cells?
Ensures monospecificity of each B cell
Which protein is a key component of both pre-BCR and BCR signaling?
Bruton's tyrosine kinase (BTK)
What occurs when a pre-B cell recognizes self-antigens?
Elimination by apoptosis
What is the role of the pre-B cell receptor in B-cell development?
Checking autoreactivity
What is the primary immunoglobulin expressed by immature B cells in the bone marrow?
IgM
In what stage of B lymphocyte differentiation do immature B cells enter primary lymphoid follicles?
Maturation stage
Which receptors are expressed on the surface of a mature, immunocompetent naïve B cell?
CD19 and CD21
What is the role of CD19 in B-cell development?
Enhance BCR signaling
Which factor contributes to anergy in B-cell clones?
Failure to respond to self-antigens
What is the fate of immature B cells that are not self-reactive?
Leave the bone marrow
Test your knowledge of the checkpoints in pre-B cell development. Learn about the expression of the pre-BCR complex, signal transduction, and the elimination of autoreactive cells. Understand the importance of passing these checkpoints in B cell maturation.
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