Questions and Answers
Who is often attributed with the discovery that cowpox induces protection against human smallpox?
Edward Jenner
What is the main function of the immune system?
To recognize and protect the body from infections
What is the origin of immunology usually attributed to?
Edward Jenner
From which type of cells are all cellular blood components derived through the process of hematopoiesis?
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Where are hematopoietic stem cells (HSCs) found in adults?
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Which cells are included in the myeloid cells?
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Which cells are part of the innate immune system?
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Where do macrophages originate from?
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What is the main function of alveolar macrophages?
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What type of macrophages are found in the liver?
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Which plasma proteins can macrophages detect using recognition receptors?
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What do macrophages produce to kill phagocytosed bacteria?
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Study Notes
Immunology Fundamentals
- Edward Jenner is often attributed with the discovery that cowpox induces protection against human smallpox.
Immune System Function
- The main function of the immune system is to protect the body against infectious organisms and other foreign substances.
Origin of Immunology
- The origin of immunology is usually attributed to Edward Jenner.
Blood Cell Development
- All cellular blood components are derived from hematopoietic stem cells (HSCs) through the process of hematopoiesis.
Hematopoietic Stem Cell Location
- In adults, hematopoietic stem cells (HSCs) are found in the bone marrow.
Myeloid Cells
- Myeloid cells include monocytes, macrophages, neutrophils, basophils, and eosinophils.
Innate Immune System
- The innate immune system includes cells such as neutrophils, macrophages, dendritic cells, and eosinophils.
Macrophage Origin
- Macrophages originate from monocytes.
Alveolar Macrophage Function
- The main function of alveolar macrophages is to remove debris and other foreign substances from the lungs.
Liver Macrophages
- Macrophages found in the liver are called Kupffer cells.
Macrophage Recognition Receptors
- Macrophages can detect pathogens using recognition receptors that recognize pathogen-associated molecular patterns (PAMPs) and other plasma proteins.
Bactericidal Action
- Macrophages produce reactive oxygen species (ROS) to kill phagocytosed bacteria.
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