Immunology Overview and Innate Immunity
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Questions and Answers

What is considered the first line of defense in innate immunity?

  • Intact skin (correct)
  • Antibodies
  • T cells
  • Phagocytes
  • Which of the following describes a chemical factor of the first line of defense?

  • Perspiration (correct)
  • Tears
  • Inflammation
  • Normal microbiota
  • What structure produces mucus as part of the physical barrier in the body?

  • Goblet cells (correct)
  • Cilia
  • Dermis
  • Sweat glands
  • Which line of defense is activated when the body experiences inflammation?

    <p>Second line of defense (B)</p> Signup and view all the answers

    What is the role of keratin in the epidermis?

    <p>Provides a protein barrier (C)</p> Signup and view all the answers

    Which immune response involves specialized lymphocytes such as T cells and B cells?

    <p>Third line of defense (A)</p> Signup and view all the answers

    Which physical factor helps to wash away microorganisms from the eye surface?

    <p>Tears from the lachrymal apparatus (A)</p> Signup and view all the answers

    What can cause infections in the skin, especially from normal skin flora?

    <p>Burns and cuts (D)</p> Signup and view all the answers

    Which term describes the branch of biology concerned with the body's defense reactions?

    <p>Immunology (B)</p> Signup and view all the answers

    What is the significance of Toll-like receptors (TLR) in immunology?

    <p>They activate innate immunity. (C)</p> Signup and view all the answers

    What type of immunity provides protection against any pathogen regardless of species?

    <p>Innate resistance (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of innate immunity?

    <p>It has a memory component. (D)</p> Signup and view all the answers

    What is the role of specialized lymphocytes in specific (acquired) immunity?

    <p>They produce antibodies. (B)</p> Signup and view all the answers

    Which statement best describes the innate defense system?

    <p>It lacks a memory component. (B)</p> Signup and view all the answers

    Which discovery was recognized with the 2011 Nobel Prize in Physiology or Medicine?

    <p>The activation of innate immunity. (A)</p> Signup and view all the answers

    What components are involved in innate (nonspecific) immunity's first line of defense?

    <p>Skin and mucous membranes (B)</p> Signup and view all the answers

    What role does the normal microbiota in the vagina play in relation to Candida albicans?

    <p>It alters pH, preventing overpopulation by Candida albicans. (B)</p> Signup and view all the answers

    Which of the following is NOT part of the second line of defense in the immune response?

    <p>Blood clotting (A)</p> Signup and view all the answers

    Which type of leukocyte is responsible for producing toxic proteins against certain parasites?

    <p>Eosinophils (B)</p> Signup and view all the answers

    What is the primary function of dendritic cells in the immune system?

    <p>To engulf pathogens and present antigens. (C)</p> Signup and view all the answers

    Which of the following statements about monocytes is true?

    <p>They become macrophages upon entering body tissues. (A)</p> Signup and view all the answers

    Natural killer (NK) cells are primarily responsible for which of the following actions?

    <p>Killing infected and tumor cells. (D)</p> Signup and view all the answers

    What is the process of phagocytosis primarily characterized by?

    <p>The engulfing of solid particles by a cell. (B)</p> Signup and view all the answers

    What type of immunity do B cells and T cells participate in?

    <p>Specific immunity (B)</p> Signup and view all the answers

    Flashcards

    Epidermis

    The outermost layer of the skin, made of dead cells and keratin, forming a strong barrier against microorganisms.

    Dermis

    The inner, thicker layer of skin, composed of connective tissue.

    Dermis

    The inner, thicker layer of skin, composed of connective tissue.

    Mucus

    A slightly viscous glycoprotein that traps and washes away microorganisms, produced by goblet cells.

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    Mucous Membranes

    An epithelial layer that lines the gastrointestinal, respiratory, and genitourinary tracts. It is a weaker physical barrier than the skin.

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    Lachrymal Apparatus

    Tears produced by the lachrymal apparatus that dilute and wash away irritants and microorganisms from the eye surface.

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    Sebum

    Oil produced by the skin that helps fight bacteria by creating an acidic environment.

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    Perspiration

    Sweat produced by the skin, containing chemicals that inhibit bacterial growth.

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    Second Line of Defense

    The second line of defense against pathogens that have bypassed the first line. It involves mechanisms like phagocytosis, inflammation, fever, and antimicrobial substances.

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    Phagocytosis

    The process by which certain cells engulf and destroy solid particles, such as bacteria and cellular debris.

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    Inflammation

    A complex response to tissue injury or infection, characterized by redness, swelling, heat, and pain.

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    Fever

    An elevated body temperature that often accompanies infection, thought to help fight off pathogens.

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    Phagocytes

    Specialized white blood cells that engulf and destroy pathogens, playing a crucial role in innate immunity.

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    Neutrophils

    Highly phagocytic and motile white blood cells that are active in the early stages of infection.

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    Basophils

    White blood cells that release histamine, a substance involved in inflammation and allergic responses.

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    Eosinophils

    White blood cells that produce toxic proteins to fight off certain parasitic infections.

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    What is Immunology?

    The study of how our body protects itself from harmful invaders like bacteria, viruses, and parasites.

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    What is Innate Immunity?

    The body's first line of defense against any pathogen. It's like a general alarm system, working quickly but without long-term memory.

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    What are the body's first line of defense?

    The front line of innate immunity like skin and mucous membranes act as physical barriers to prevent pathogens from entering the body.

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    What are phagocytes?

    They are part of the second line of defense, actively engulfing and destroying pathogens. They're like tiny Pac-Man, gobbling up bad guys.

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    What is inflammation?

    It's the body's response to injury or infection. It's like a red alert, bringing in more immune cells to fight the invaders. It's also how you get bruises and swelling!

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    What is fever?

    It's the body's internal thermostat. It's like turning up the heat to make it harder for pathogens to survive.

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    What is Adaptive Immunity?

    It's the body's specific defense system. It learns and remembers specific pathogens and mounts a targeted attack.

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    What are lymphocytes?

    They are specialized immune cells like B and T cells that remember specific pathogens, allowing for a faster and more effective response upon re-exposure. They're like your body's memory cells.

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    Study Notes

    Immunology Overview

    • Immunology is the branch of biology studying the body's defense reactions.
    • Immunity is derived from the Latin word "immunis," meaning "free of burden."
    • Pathogenic microorganisms (bacteria, viruses, fungi, and parasites) are present in the environment and can cause disease.
    • Without an immune system, humans would constantly become ill and possibly die due to infections.

    Innate Immunity

    • Innate immunity constitutes the body's first line of defense against infectious agents, serving as the body's early warning system.
    • It provides a non-specific defense against any pathogen, regardless of its type.
    • Innate immunity is a two-line defense system, including physical factors (skin and mucous membranes) and a second line of defense involving phagocytes, inflammation, fever, and antimicrobial substances.
    • Innate immunity lacks a memory component, meaning it cannot recognize or respond to previously encountered pathogens.

    Specific (Adaptive) Immunity

    • Specific immunity is the body's third line of defense, which is acquired throughout life.
    • It's a specific response to a particular microbe.
    • Specific immunity has long-term memory for specific antigens.
    • This immunity is based on specialized immune cells (B and T cells) and specific proteins like antibodies.

    Innate vs. Adaptive Immunity

    Feature Innate Immunity Adaptive Immunity
    Defense Line First and second line Third line
    Specificity Non-specific Specific
    Memory No memory Long-term memory
    Cells involved Phagocytes, natural killer cells, etc. B cells, T cells
    Response Time Rapid Slower

    Nonspecific (Innate) Resistance

    • First Line of Defense:

      • Physical factors: skin, mucous membranes, mucus, tears, saliva, hairs, cilia, urine, vomiting, and defecation.
      • Chemical factors: sebum, perspiration, lysozyme, gastric juice. The skin's epidermis (outer layer) is a strong physical barrier due to the keratin protein.
    • Mucous Membranes: Consist of epithelial layers and connective tissue; line the gastrointestinal, respiratory, and genitourinary tracts. Mucus, a glycoprotein, is produced by goblet cells.

    • Lachrymal Apparatus: Tears produced by the lacrimal glands protect the eye surface.

    • Salivary Glands: Saliva produced by salivary glands dilutes microorganisms and removes them from the teeth and mouth;

    • Hair: Nose hairs trap airborne microorganisms, dust, and pollutants.

    • Cilia: Cilia in the respiratory tract move foreign particles upward toward the throat.

    • Urine: Flow of urine prevents microbial colonization of the urinary tract.

    Chemical Factors

    • Sebum: Produced by sebaceous glands, contains unsaturated fatty acids to prevent bacterial and fungal growth.
    • Perspiration: Produced by sweat glands helps regulate temperature and remove microorganisms.
    • Lysozyme: Enzyme found in tears, saliva, nasal secretions, urine, and tissue fluids, that breaks down peptidoglycan in the cell walls of gram-positive bacteria.
    • Gastric Juice: The high acidity of the stomach destroys most bacteria and bacterial toxins (pH 1.2-3), while some pathogens survive acidic conditions.

    Normal Microbiota

    • Normal microbiota prevents pathogen overgrowth by competing for nutrients, producing harmful substances that inhibit pathogens, and altering environmental conditions.

    Phagocytosis

    • This is the cellular process of engulfing and destroying solid particles like bacteria, debris, and pathogens.
    • Phagocytosis has four steps: chemotaxis, adherence, ingestion, and digestion.
    • Lysosomal bactericidal factors include hydrolytic enzymes (e.g., lysozyme, lipase, protease) and toxic oxygen products (e.g., hydrogen peroxide, singlet oxygen).

    Inflammation

    • Inflammation is the body's defensive response to tissue damage (from microbial infections, physical damage, or chemical agents).
    • Inflammation is characterized by redness, pain, heat, and swelling.
    • Inflammation has beneficial functions, including destroying and removing injurious agents, limiting microbial effects, and repairing damaged tissues.
    • Inflammation is divided into Vasodilation and increased permeability of blood vessels (caused by chemical mediators), Phagocyte migration (Neutrophils, Monocytes), and Tissue Repair (skin regeneration).

    Fever

    • Fever is an abnormally high body temperature, controlled by the hypothalamus.
    • Typically set at 37°C, infection can cause a rise in the body temperature related to the cytokines (e.g., IL-1) released from macrophages that triggers the hypothalamus to release prostaglandins that reset the hypothalamic thermostat, and increase body temperature.
    • High temperatures can slow down the growth rate of bacteria and viruses and increase the body's immune response.

    Antimicrobial Substances

    • Interferons and complement proteins are a part of the body's antimicrobial arsenal.
    • Interferons are proteins that help prevent viral infections.
    • Complement proteins enhance various aspects of the immune system.

    Formed Elements of Blood

    • Blood consists of plasma and formed elements (erythrocytes, leukocytes, and platelets).
    • Leukocytes (white blood cells) are crucial for the immune system, further categorized into granulocytes and agranulocytes.

    Granulocytes

    • Neutrophils are highly phagocytic and motile, active in initial infection phases.
    • Basophils release substances like histamine, playing a role in inflammation and allergic responses.
    • Eosinophils produce toxic proteins against parasites.

    Agranulocytes

    • Dendritic cells have extensions resembling nerve cells, abundant in skin, mucosal membranes, and lymph nodes. They are antigen-presenting cells.
    • Monocytes are phagocytic after leaving the blood and becoming macrophages.
    • Lymphocytes (B and T cells) are vital for specific immunity, responsible for antibody production (B cells) and cell-mediated immunity (T cells).

    Natural Killer (NK) Cells

    • Found in blood, spleen, lymph nodes, and bone marrow.
    • NK cells kill various infected body cells and tumor cells by recognizing and destroying abnormal cells.

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    Description

    This quiz covers the fundamentals of immunology, focusing on the body's defense mechanisms against pathogens. Learn about innate immunity, its role as the first line of defense, and its characteristics. Explore how the immune system protects us from infections and illness.

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