Questions and Answers
What does IgA primarily do?
What is the role of IgD?
Attached to and activates B cells (clonal selection)
What does IgE trigger?
Release of histamine from mast cells
What is the most common type of immunoglobulin?
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What type of structure do IgM immunoglobulins form?
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What characteristic do IgA and IgM share?
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Study Notes
Immunoglobulin Classes Overview
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IgA:
- Predominantly located in mucus and body secretions.
- Exists as dimers, enhancing its ability to protect mucosal surfaces.
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IgD:
- Functions as a receptor on B cells, initiating clonal selection.
- Involved in the activation of B cells for an adaptive immune response.
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IgE:
- Plays a critical role in allergic reactions by triggering histamine release from mast cells.
- Associated with responses to parasitic infections and allergens.
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IgG:
- Most abundant immunoglobulin in blood circulation.
- Key role in opsonization, marking pathogens for destruction by immune cells.
- Capable of providing passive immunity to the fetus during pregnancy.
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IgM:
- Forms pentamers, making it effective in the primary immune response.
- First antibody produced in response to an infection.
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IgA & IgM Characteristics:
- Both immunoglobulins exhibit high avidity, allowing them to bind multiple antigens simultaneously.
- Presence of a J-chain provides unique structural features essential for their function.
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Description
Test your knowledge on the five classes of immunoglobulins with these flashcards. Each card provides key definitions and functions crucial to understanding immune responses. Ideal for students studying immunology or related life sciences.
