Immunology Exam 2: Generation of Antigen Receptors
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Questions and Answers

What is the primary function of the constant region of the light chain?

  • To interact with different immune responses and effector cells
  • To provide variability in antibody production
  • To bring together the light and heavy chains (correct)
  • To specify the antibody's antigen-binding site

How many constant domains are present in a heavy chain?

  • 3 or 4 (correct)
  • 7 or 8
  • 5 or 6
  • 1 or 2

What is the purpose of somatic recombination in the generation of antigen receptors?

  • To combine the light and heavy chains
  • To increase the diversity of the antibody repertoire
  • To reduce the variability of the antibody response
  • To permenantly change the DNA of the heavy chain locus (correct)

What is the role of the hypervariable regions in the antigen-antibody interaction?

<p>To generate a high level of antigen specificity (C)</p> Signup and view all the answers

What is the result of combining the V, D, and J segments in the heavy chain locus?

<p>A diverse range of variable exons (D)</p> Signup and view all the answers

What is the purpose of RAG proteins in V(D)J recombination?

<p>To recognize and cleave the RSS regions (B)</p> Signup and view all the answers

What is the result of the cleavage reaction in V(D)J recombination?

<p>A blunt double-strand break at the coding ends (C)</p> Signup and view all the answers

What is the role of Ku proteins in V(D)J recombination?

<p>To recruit DNA ligase to join the signal ends (D)</p> Signup and view all the answers

What is the result of somatic hypermutation in B cells?

<p>An increase in the diversity of antibodies (B)</p> Signup and view all the answers

What is the purpose of the tetrameric complex of RAG1 and RAG2 in V(D)J recombination?

<p>To bind to the RSS regions (D)</p> Signup and view all the answers

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