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Immunology Exam 2: Generation of Antigen Receptors

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Immunology Exam 2: Generation of Antigen Receptors

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Questions and Answers

What is the primary function of the constant region of the light chain?

To interact with different immune responses and effector cells

To provide variability in antibody production

To bring together the light and heavy chains (correct)

To specify the antibody's antigen-binding site

How many constant domains are present in a heavy chain?

3 or 4 (correct)

7 or 8

5 or 6

1 or 2

What is the purpose of somatic recombination in the generation of antigen receptors?

To combine the light and heavy chains

To increase the diversity of the antibody repertoire

To reduce the variability of the antibody response

To permenantly change the DNA of the heavy chain locus (correct)

What is the role of the hypervariable regions in the antigen-antibody interaction?

To generate a high level of antigen specificity Signup and view all the answers

What is the result of combining the V, D, and J segments in the heavy chain locus?

A diverse range of variable exons Signup and view all the answers

What is the purpose of RAG proteins in V(D)J recombination?

To recognize and cleave the RSS regions Signup and view all the answers

What is the result of the cleavage reaction in V(D)J recombination?

A blunt double-strand break at the coding ends Signup and view all the answers

What is the role of Ku proteins in V(D)J recombination?

To recruit DNA ligase to join the signal ends Signup and view all the answers

What is the result of somatic hypermutation in B cells?

An increase in the diversity of antibodies Signup and view all the answers

What is the purpose of the tetrameric complex of RAG1 and RAG2 in V(D)J recombination?

To bind to the RSS regions Signup and view all the answers