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Questions and Answers
What is the main goal of having a large repertoire of antigen receptors?
What is the main goal of having a large repertoire of antigen receptors?
What is the consequence of having 'holes in the repertoire' of antigen receptors?
What is the consequence of having 'holes in the repertoire' of antigen receptors?
Why is it necessary for the immune system to have a large repertoire of antigen receptors?
Why is it necessary for the immune system to have a large repertoire of antigen receptors?
What would be the outcome if the immune system has 'holes in the repertoire' of antigen receptors?
What would be the outcome if the immune system has 'holes in the repertoire' of antigen receptors?
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What are the two contradictory requirements of the immune system regarding the repertoire of antigen receptors?
What are the two contradictory requirements of the immune system regarding the repertoire of antigen receptors?
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What can occur as a result of a disturbance in the BCR and TCR system?
What can occur as a result of a disturbance in the BCR and TCR system?
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What can happen if BCR and TCR do not function properly?
What can happen if BCR and TCR do not function properly?
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What is a potential consequence of an imbalance in the BCR and TCR system?
What is a potential consequence of an imbalance in the BCR and TCR system?
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What is the result of a disturbance in the balance of BCR and TCR?
What is the result of a disturbance in the balance of BCR and TCR?
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What can happen if the BCR and TCR system is not functioning properly?
What can happen if the BCR and TCR system is not functioning properly?
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What is the primary function of medullary thymic epithelial cells (mTECs)?
What is the primary function of medullary thymic epithelial cells (mTECs)?
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Where are the medullary thymic epithelial cells (mTECs) primarily located?
Where are the medullary thymic epithelial cells (mTECs) primarily located?
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What is the significance of mTECs expressing proteins that are otherwise strictly tissue restricted?
What is the significance of mTECs expressing proteins that are otherwise strictly tissue restricted?
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What is the result of mTECs expressing proteins that are otherwise strictly tissue restricted?
What is the result of mTECs expressing proteins that are otherwise strictly tissue restricted?
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What is the main role of the thymus in the immune system?
What is the main role of the thymus in the immune system?
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Why does the receptor repertoire need to have high diversity?
Why does the receptor repertoire need to have high diversity?
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What is the consequence of a receptor repertoire with low diversity?
What is the consequence of a receptor repertoire with low diversity?
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What is the role of the immune system in relation to the organism that harbors it?
What is the role of the immune system in relation to the organism that harbors it?
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What is the purpose of shaping the receptor repertoire?
What is the purpose of shaping the receptor repertoire?
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What would happen if the immune system attacks the organism that harbors it?
What would happen if the immune system attacks the organism that harbors it?
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What is the primary function of MTECs in the immune system?
What is the primary function of MTECs in the immune system?
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What is the characteristic of the antigens expressed by MTECs?
What is the characteristic of the antigens expressed by MTECs?
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What is the significance of MTECs expressing thousands of antigens?
What is the significance of MTECs expressing thousands of antigens?
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What is the primary consequence of MTECs expressing a large number of antigens?
What is the primary consequence of MTECs expressing a large number of antigens?
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What is the relationship between MTECs and the immune system?
What is the relationship between MTECs and the immune system?
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Study Notes
Immune System Requirements
- The immune system needs to balance two contradictory requirements: having a large repertoire of antigen receptors to detect pathogens and avoiding self-attack.
- A large repertoire of antigen receptors is necessary to prevent "holes in the repertoire" that pathogens could exploit to evade immune detection.
Receptor Diversity
- The diversity of TCR (T-cell receptor) and BCR (B-cell receptor) is crucial for immune detection.
- The receptor repertoire must be diverse to recognize and respond to various pathogens.
Immune System Balance
- The immune system must be shaped to prevent attacking the organism it inhabits.
- The receptor repertoire must be balanced to avoid self-attack and recognize external antigens.
Consequences of Disturbances
- Any disturbance in the immune system balance can have pathogenic or lethal consequences.
- Consequences may include infections, unwanted reactions with autoantigens, or allergic reactions to harmless external antigens.
Role of Medullary Thymic Epithelial Cells (mTECs)
- Specialized cells in the thymus, mTECs, express proteins that are usually tissue-restricted.
- mTECs express hundreds or thousands of diverse antigens that represent almost all tissues in the body.
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Description
The immune system must balance a large repertoire of antigen receptors to avoid detection evasion by pathogens. Learn how the immune system fulfills this requirement.