Immunology: Delayed Hypersensitivity Reaction
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Questions and Answers

What type of reaction is characterized by the activation of T-lymphocytes and the production of effector cytokines?

Delayed type hypersensitivity reaction

What are the two effector cytokines produced by activated T-lymphocytes in a delayed type hypersensitivity reaction?

Interferon gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α)

What type of cells are attracted to the site of infection by the effector cytokines produced by activated T-lymphocytes?

Macrophages, lymphoid cells, granulocytes, and others

What is the purpose of granuloma formation in the context of a delayed type hypersensitivity reaction?

<p>To limit the spread of Mycobacterium tuberculosis in the body</p> Signup and view all the answers

What is the specific pathogen that delayed type hypersensitivity reactions are involved in defending against?

<p>Mycobacterium tuberculosis</p> Signup and view all the answers

What is the primary mechanism by which a delayed type hypersensitivity reaction limits the spread of Mycobacterium tuberculosis in the body?

<p>Formation of granulomas</p> Signup and view all the answers

What is the role of IFN-ϒ and TNF-α in a delayed type hypersensitivity reaction?

<p>To attract immune cells to the site of infection</p> Signup and view all the answers

How do activated T-lymphocytes contribute to the inflammation response in a delayed type hypersensitivity reaction?

<p>By producing effector cytokines that attract immune cells</p> Signup and view all the answers

What is the outcome of the interaction between activated T-lymphocytes and immune cells in a delayed type hypersensitivity reaction?

<p>Formation of granulomas and inflammation</p> Signup and view all the answers

What is the key characteristic of immune cells that are attracted to the site of infection in a delayed type hypersensitivity reaction?

<p>They are involved in the formation of granulomas</p> Signup and view all the answers

Study Notes

Delayed Type Hypersensitivity Reaction

  • Activated T-lymphocytes produce effector cytokines interferon gamma (IFN-ϒ) and tumor necrosis factor-alpha (TNF-α) in response to infection.
  • These cytokines attract a large number of different cells, including macrophages, lymphoid cells, granulocytes, and others, from capillaries to the site of infection.
  • The attracted cells play a crucial role in the formation of granulomas, which helps to limit the spread of Mycobacterium tuberculosis in the body.

Delayed Type Hypersensitivity Reaction

  • Activated T-lymphocytes produce effector cytokines interferon gamma (IFN-ϒ) and tumor necrosis factor-alpha (TNF-α) in response to infection.
  • These cytokines attract a large number of different cells, including macrophages, lymphoid cells, granulocytes, and others, from capillaries to the site of infection.
  • The attracted cells play a crucial role in the formation of granulomas, which helps to limit the spread of Mycobacterium tuberculosis in the body.

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Description

Learn about delayed type hypersensitivity reaction, a type of hypersensitivity inflammatory reaction involving activated T-lymphocytes and various immune cells. Understand their role in combating infections like tuberculosis.

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