Immunology: Defense Against Infection
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Questions and Answers

What are the two classes of MHC proteins found in the body?

  • Class IV MHC proteins and Class V MHC proteins
  • Class I MHC proteins and Class III MHC proteins
  • Class III MHC proteins and Class IV MHC proteins
  • Class I MHC proteins and Class II MHC proteins (correct)
  • What type of graft is transplanted from one part of the body to another?

  • Xenograft
  • Isograft
  • Autograft (correct)
  • Allograft
  • What is the primary function of Toll-like receptors in the immune response?

  • To produce antibodies against antigens
  • To recognize and respond to pathogen-associated molecular patterns (correct)
  • To recognize and bind to specific antigens
  • To facilitate phagocytosis of foreign particles
  • What is the purpose of ABO blood typing?

    <p>To classify blood based on the presence of inherited antigenic carbohydrates on the surface of red blood cells (D)</p> Signup and view all the answers

    What is the purpose of a cytotoxic cross match test in transplantation?

    <p>To detect the presence of anti-donor antibodies in the recipient's serum (C)</p> Signup and view all the answers

    What is the primary function of phagocytosis in the immune response?

    <p>To engulf and eliminate foreign particles and cellular debris (A)</p> Signup and view all the answers

    What type of antibody is typically attached to the surface of B cells?

    <p>IgD (B)</p> Signup and view all the answers

    What is the primary function of lymph nodes in the immune system?

    <p>To act as filters, collecting and destroying bacteria and viruses (A)</p> Signup and view all the answers

    What is the role of CD8+ T cells in the adaptive immune system?

    <p>To destroy infected cells by recognizing antigens presented on MHC-I (C)</p> Signup and view all the answers

    What is the term for the small, accessible portion of an antigen that is recognized by lymphocytes?

    <p>Epitope (D)</p> Signup and view all the answers

    What type of antibody is responsible for preventing attachment of pathogens to epithelial cell surfaces?

    <p>IgA (B)</p> Signup and view all the answers

    What is the term for the binding of the Fc portion of an antibody to the Fc-receptor on an effector cell?

    <p>Immunoglobin binding (D)</p> Signup and view all the answers

    What is the estimated number of different antibody molecules in an individual?

    <p>1000 (A)</p> Signup and view all the answers

    What is the primary reason for using humanized antibodies over mouse antibodies?

    <p>To reduce the risk of inducing human anti-mouse antibodies (A)</p> Signup and view all the answers

    What is the primary site of mucosal immunity in the body?

    <p>Intestinal mucous epithelium (C)</p> Signup and view all the answers

    What is the primary function of macrophages in the immune system?

    <p>To collect and destroy bacteria and viruses (C)</p> Signup and view all the answers

    Flashcards

    What are the two classes of MHC proteins?

    The two main categories of MHC proteins, responsible for presenting antigens to T cells.

    What is an autograft?

    A type of graft where tissue is transplanted from one part of a person's body to another part of the same body.

    What is the function of Toll-like receptors?

    Specialized receptors on immune cells that detect and respond to pathogen-associated molecular patterns (PAMPs).

    What is the purpose of ABO blood typing?

    A system used to classify blood based on the presence or absence of specific carbohydrates (antigens) on red blood cell surfaces.

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    What is a cytotoxic cross match test?

    A test performed to determine if the recipient of a transplant has antibodies against the donor's tissues.

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    What is the primary function of phagocytosis?

    A process by which immune cells engulf and destroy foreign particles, microbes, and cellular debris.

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    What type of antibody is typically attached to the surface of B cells?

    A type of antibody predominantly found on the surface of B cells, playing a role in B cell activation.

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    What is the primary function of lymph nodes?

    Small, bean-shaped organs that filter lymph fluid, trapping and destroying pathogens.

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    What is the role of CD8+ T cells?

    A type of T cell that specifically targets and destroys cells infected with viruses or other intracellular pathogens.

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    What is an epitope?

    The specific portion of an antigen that is recognized and bound by lymphocytes, such as B cells and T cells.

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    What type of antibody prevents pathogens from attaching to epithelial surfaces?

    A type of antibody found in mucus secretions, primarily in the respiratory and digestive tracts.

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    What is immunoglobin binding?

    The binding of the Fc portion of an antibody to the Fc receptor on an effector cell like a macrophage or NK cell.

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    How many different antibody molecules are in an individual?

    A vast number, estimated to be around 1000, representing the diverse range of antibodies an individual can produce.

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    Why are humanized antibodies used over mouse antibodies?

    Humanized antibodies have a reduced risk of inducing human anti-mouse antibodies (HAMAs), making them more effective in fighting diseases.

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    What is the primary site of mucosal immunity?

    The main site within the body where the mucosal immune system operates, protecting against pathogens entering through mucous membranes.

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    What is the primary function of macrophages?

    To engulf and destroy bacteria and viruses, playing a crucial role in innate immunity.

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