WK 11: Basic Immunology 2
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Questions and Answers

What is the role of T helper cells (CD4+) in the immune system?

  • Produces antibodies
  • Fights against intracellular pathogens
  • Directly kills infected or damaged cells
  • Enhances humoral and cellular immune responses coordination (correct)

Which type of immunity is mainly responsible for fighting extracellular pathogens like bacteria?

  • Cellular immunity
  • Innate immune system
  • Humoral immunity (correct)
  • Cytotoxic T-cells (CD8+)

Which component is key in cellular immunity and is responsible for directly killing infected cells?

  • Plasma cells
  • NK cells
  • Cytotoxic T-cells (CD8+) (correct)
  • B cells

Which lymphocyte type is primarily part of the innate immune system?

<p>Natural killer cells (NK cells) (C)</p> Signup and view all the answers

Which type of immunity is mainly effective against intracellular pathogens such as certain viruses and bacteria?

<p>Cellular immunity (D)</p> Signup and view all the answers

Which type of white cell is associated with the innate immune system and is involved in ingesting foreign particles?

<p>Monocytes / macrophages (B)</p> Signup and view all the answers

What is the role of CD4+ helper T cells in the immune system?

<p>Secrete antibodies to clear pathogens (B)</p> Signup and view all the answers

Which part of the immune system is adapted to clearing intracellular pathogens?

<p>Adaptive immune system (B)</p> Signup and view all the answers

How do CD8+ cytotoxic T lymphocytes contribute to immunity?

<p>Kill infected human cells (C)</p> Signup and view all the answers

Which immune cells have the ability to detect viral antigens expressed by infected cells?

<p>Dendritic cells (C)</p> Signup and view all the answers

In which type of infection do CD8+ cytotoxic T lymphocytes play a crucial role in clearing pathogens?

<p>Intracellular pathogen infection (A)</p> Signup and view all the answers

What is the primary function of B cells when stimulated by helper T cells?

<p>Produce antibodies (D)</p> Signup and view all the answers

What is the primary function of central tolerance in lymphocyte development?

<p>To eliminate self-reactive clones or convert them into Treg cells (B)</p> Signup and view all the answers

How do innate and adaptive immune responses interplay to clear a pathogen?

<p>Innate responses trigger adaptive responses through antigen presentation (C)</p> Signup and view all the answers

What is the role of immunological memory in adaptive immunity?

<p>To provide long-term protection against specific pathogens through antigen-specific T cells and B cells (C)</p> Signup and view all the answers

How do cancer cells evade the adaptive immune system?

<p>By downregulating MHC I expression to avoid recognition by T cells (D)</p> Signup and view all the answers

What type of immunity is involved in the production of antibodies against pathogens?

<p>Humoral immunity (C)</p> Signup and view all the answers

What is the primary function of peripheral tolerance in adaptive immunity?

<p>To induce anergy or regulatory T cell activity in mature T cells (A)</p> Signup and view all the answers

What is the primary function of professional antigen-presenting cells in humoral immunity?

<p>To present antigen to helper T cells via MHC class II (C)</p> Signup and view all the answers

What type of pathogens is humoral immunity primarily responsible for fighting off?

<p>Extracellular pathogens such as bacteria (A)</p> Signup and view all the answers

What is the role of activated CD8+ cells in cellular immunity?

<p>To directly kill infected cells (B)</p> Signup and view all the answers

What is a key characteristic of all nucleated human cells?

<p>They have the ability to present antigen via MHC class I (A)</p> Signup and view all the answers

What is the primary difference between humoral and cellular immunity?

<p>Humoral immunity fights off extracellular pathogens, while cellular immunity fights off intracellular pathogens (D)</p> Signup and view all the answers

What type of T cells are triggered by professional antigen-presenting cells in humoral immunity?

<p>Helper T cells (C)</p> Signup and view all the answers

What is the key cytokine that promotes CD8+ cell differentiation and proliferation in response to viruses?

<p>Interferon-É£ (A)</p> Signup and view all the answers

How do CD8+ cytotoxic T lymphocytes kill virus-infected cells?

<p>Release cytotoxic compounds like perforin, granzymes, and granulysin (D)</p> Signup and view all the answers

Which type of T lymphocytes assist macrophages to kill microbes they have ingested?

<p>CD4+ helper T lymphocytes (B)</p> Signup and view all the answers

What is the main function of innate immune responses when a pathogen breaches the epithelial or mucosal barrier?

<p>Detect and initiate a rapid response to the pathogen (C)</p> Signup and view all the answers

What happens to the immune response once the invading pathogen is cleared?

<p>The stimulus for the immune response is removed (C)</p> Signup and view all the answers

Which type of immune response shows specificity and memory to provide a targeted response to the foreign pathogen?

<p>Adaptive immune response (C)</p> Signup and view all the answers

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