Immunology: Cytokines and Immune Deficiencies
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Questions and Answers

What characterizes many of the genes mutated in primary immunodeficiencies?

  • They are multifunctional and involved in several important pathways. (correct)
  • They are only involved in one important pathway.
  • They are exclusively involved in autoimmunity.
  • They are redundant and thereby not crucial for immune function.

    • What is the main challenge in selecting genes to study in primary immunodeficiencies?

  • Identifying the genes that are multifunctional.
  • Distinguishing the genes that are redundant.
  • Selecting the genes that are important to students of Clinical Immunology. (correct)
  • Choosing the genes that are involved in autoimmunity.

    • Who is credited with helping to keep the author's rheumatology up to date?

  • Georg Hollander.
  • Meilyn Hew.
  • Siraj Misbah. (correct)
  • Beth Psaila.

    • What is the characteristic of CD18/CD11 deficiency?

    <p>Marked neutrophil leucocytosis</p> Signup and view all the answers

    What is the result of defective expression of CD15?

    <p>Severe immunodeficiency</p> Signup and view all the answers

    What is mediated by E-selectin (CD62E) and Sialyl Lewis X (CD15)?

    <p>Transient adhesion and rolling of leucocytes on monocytes</p> Signup and view all the answers

    What is characteristic of Glanzmann’s disease?

    <p>Clotting disorder</p> Signup and view all the answers

    What is mediated by ICAM-1 on endothelium?

    <p>Tight adhesion between all leucocytes and endothelium</p> Signup and view all the answers

    What is the main consequence of gene mutations in IL-12 receptor or IFN-γ receptor deficiencies?

    <p>Immunodeficiency</p> Signup and view all the answers

    Which of the following cytokines is NOT part of the IL-10 family?

    <p>IL-23</p> Signup and view all the answers

    What is the function of Fc receptors on phagocytic cells and NK cells?

    <p>Effector functions, such as phagocytosis</p> Signup and view all the answers

    What is the common structural chain shared by the receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-23?

    <p>γ-chain</p> Signup and view all the answers

    What is the characteristic of chemokine receptors?

    <p>They are transmembrane receptors that activate internal signalling pathways</p> Signup and view all the answers

    What is the purpose of the redundancy in cytokine receptors?

    <p>To provide a safety net for crucial immune functions</p> Signup and view all the answers

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