14 Questions
What characterizes many of the genes mutated in primary immunodeficiencies?
They are multifunctional and involved in several important pathways.
What is the main challenge in selecting genes to study in primary immunodeficiencies?
Selecting the genes that are important to students of Clinical Immunology.
Who is credited with helping to keep the author's rheumatology up to date?
Siraj Misbah.
What is the characteristic of CD18/CD11 deficiency?
Marked neutrophil leucocytosis
What is the result of defective expression of CD15?
Severe immunodeficiency
What is mediated by E-selectin (CD62E) and Sialyl Lewis X (CD15)?
Transient adhesion and rolling of leucocytes on monocytes
What is characteristic of Glanzmann’s disease?
Clotting disorder
What is mediated by ICAM-1 on endothelium?
Tight adhesion between all leucocytes and endothelium
What is the main consequence of gene mutations in IL-12 receptor or IFN-γ receptor deficiencies?
Immunodeficiency
Which of the following cytokines is NOT part of the IL-10 family?
IL-23
What is the function of Fc receptors on phagocytic cells and NK cells?
Effector functions, such as phagocytosis
What is the common structural chain shared by the receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-23?
γ-chain
What is the characteristic of chemokine receptors?
They are transmembrane receptors that activate internal signalling pathways
What is the purpose of the redundancy in cytokine receptors?
To provide a safety net for crucial immune functions
This quiz covers the IL-12 family of cytokines, IL-10 family, and primary immune deficiencies resulting from gene mutations. Topics include severe combined immune deficiency, IL-12 receptor deficiency, and IFN-γ receptor deficiencies.
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