Immunology Chapter 14-16-17
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Questions and Answers

What are PAMPs and their significance in innate immunity?

  • They are pathogen-associated molecular patterns recognized by immune cells. (correct)
  • They are patterns that help activate adaptive immunity.
  • They are types of cytokines released during inflammation.
  • They represent immune cells that respond to pathogens.
  • Which statement correctly describes the difference between granulocytes and agranulocytes?

  • Granulocytes are exclusively found in the bloodstream; agranulocytes are not.
  • Agranulocytes are all involved in the adaptive immune response; granulocytes are not.
  • Granulocytes have granules that assist in inflammation; agranulocytes do not. (correct)
  • Agranulocytes are larger than granulocytes and reside in lymphatic tissues.
  • What is the primary function of lysozyme?

  • To serve as a signal for the activation of adaptive immunity.
  • To facilitate cytokine production during an immune response.
  • To promote vasodilation and increase blood flow.
  • To break down bacterial cell walls and provide an antimicrobial effect. (correct)
  • Which of the following correctly outlines the three stages of inflammation?

    <p>Vasodilation, recruitment of leukocytes, resolution.</p> Signup and view all the answers

    What role do cytokines play in inflammation?

    <p>They help recruit other immune cells to the site of infection.</p> Signup and view all the answers

    What initiates the classical complement activation pathway?

    <p>Binding of antibodies to cell surface antigens.</p> Signup and view all the answers

    How do probiotics differ from prebiotics?

    <p>Probiotics are live microorganisms; prebiotics are non-digestible food components that promote beneficial bacteria.</p> Signup and view all the answers

    Why might chronic use of aspirin and ibuprofen impact the immune system?

    <p>They can lead to a reduced inflammatory response and affect the regulation of immune functions.</p> Signup and view all the answers

    What is the primary role of memory cells in the immune response?

    <p>To remember the specific antigens for quicker response in future infections</p> Signup and view all the answers

    Which class of antibody is primarily involved in protection during the initial stages of infection?

    <p>IgM</p> Signup and view all the answers

    What is one key difference between T-dependent and T-independent antigens?

    <p>T-independent antigens do not require B cell activation</p> Signup and view all the answers

    What is clonal selection's primary outcome during an immune response?

    <p>The production of identical plasma cells and memory cells</p> Signup and view all the answers

    Which of the following statements best describes the structure of an antibody?

    <p>Antibodies are composed of two heavy chains and two light chains</p> Signup and view all the answers

    What does the term 'pathogenesis' refer to?

    <p>The process by which disease develops.</p> Signup and view all the answers

    How does microbial antagonism (competitive exclusion) affect opportunistic pathogens?

    <p>It prevents the establishment of pathogens by normal microbiota.</p> Signup and view all the answers

    What is the primary distinction between a communicable disease and a contagious disease?

    <p>Contagious diseases are easily transmitted between individuals, while communicable diseases may require vectors.</p> Signup and view all the answers

    What is 'herd immunity' and how does it relate to vaccination effects on vulnerable populations?

    <p>It describes the protection of non-immune individuals when a significant portion of a population is immune.</p> Signup and view all the answers

    Which of the following best describes the concept of vehicle transmission in disease spread?

    <p>Spread through contaminated objects or surfaces.</p> Signup and view all the answers

    What distinguishes a communicable disease from a contagious disease?

    <p>A communicable disease can be transmitted in multiple ways.</p> Signup and view all the answers

    Which term best describes the relationship between humans and the normal microbiota?

    <p>Mutualism</p> Signup and view all the answers

    What is the consequence of high herd immunity for a fully vaccinated individual compared to someone who is unvaccinated?

    <p>The vaccinated individual has a lower risk of exposure.</p> Signup and view all the answers

    Which process describes the effect of antibiotics on normal microbiota?

    <p>Antibiotics selectively increase the levels of opportunistic pathogens.</p> Signup and view all the answers

    Which of the following best defines the term 'zoonoses'?

    <p>Diseases transmitted from animals to humans.</p> Signup and view all the answers

    What is the primary function of T-dependent antigens?

    <p>They require T cell assistance for B cell activation.</p> Signup and view all the answers

    Which class of antibody has the longest half-life in circulation?

    <p>IgG</p> Signup and view all the answers

    What distinguishes plasma cells from memory cells?

    <p>Plasma cells are involved in rapid response to pathogens.</p> Signup and view all the answers

    Which structure is associated with the constant region of an antibody?

    <p>Stability and interaction with complement proteins.</p> Signup and view all the answers

    What is the role of haptens in the immune response?

    <p>They are small molecules that bind to proteins to form antigens.</p> Signup and view all the answers

    What is the primary function of toll-like receptors (TLRs) in the immune system?

    <p>To recognize pathogen-associated molecular patterns (PAMPs)</p> Signup and view all the answers

    Which of the following accurately describes the classical pathway of complement activation?

    <p>Begins with the binding of antibodies to antigens</p> Signup and view all the answers

    Which of the following substances is released during the inflammatory process to cause vasodilation?

    <p>Histamine</p> Signup and view all the answers

    Which of the following best describes the roles of prebiotics in immunity?

    <p>They stimulate the growth of beneficial gut bacteria.</p> Signup and view all the answers

    Which cell type is primarily responsible for phagocytosis during the immune response?

    <p>Macrophages</p> Signup and view all the answers

    What is the main effect of cytokines during the inflammatory response?

    <p>To facilitate communication between immune cells</p> Signup and view all the answers

    Which statement best summarizes the purpose of inflammation?

    <p>To isolate and eliminate pathogens and initiate healing</p> Signup and view all the answers

    Which feature distinguishes eosinophils from other granulocytes?

    <p>Role in allergic responses and parasitic infections</p> Signup and view all the answers

    The classical pathway of complement activation begins with antibody-antigen binding and ends with the formation of a transmembrane channel in bacterial membranes.

    <p>True</p> Signup and view all the answers

    Aspirin interferes with the production of cytokines and has no effect on prostaglandin levels.

    <p>False</p> Signup and view all the answers

    Granulocytes are classified into three types, which include neutrophils, sentinel cells, and macrophages.

    <p>False</p> Signup and view all the answers

    Inflammation involves three stages, which are redness, heat, and pain.

    <p>False</p> Signup and view all the answers

    Prebiotics serve as nutrients for probiotics to help enhance the immune response.

    <p>True</p> Signup and view all the answers

    TLRs (toll-like receptors) are part of the adaptive immune system and specifically target pathogen-associated molecular patterns (PAMPs).

    <p>False</p> Signup and view all the answers

    The second line of defense in immunity involves specific immune responses like those seen in vaccinations.

    <p>False</p> Signup and view all the answers

    C-reactive protein (CRP) plays a significant role in detecting tissue damage and inflammation during an immune response.

    <p>True</p> Signup and view all the answers

    Memory cells and plasma cells both originate from clonal selection.

    <p>True</p> Signup and view all the answers

    The Major Histocompatibility Complex (MHC) is solely responsible for the production of antibodies.

    <p>False</p> Signup and view all the answers

    IgE antibodies are primarily involved in immediate allergic responses.

    <p>True</p> Signup and view all the answers

    T-independent antigens require T cell help for the activation of B cells.

    <p>False</p> Signup and view all the answers

    The Fc region of an antibody is involved in antigen binding.

    <p>False</p> Signup and view all the answers

    Epidemiology primarily focuses on the study of communicable diseases.

    <p>False</p> Signup and view all the answers

    Normal microbiota can provide a protective effect against infectious diseases through microbial antagonism.

    <p>True</p> Signup and view all the answers

    Zoonoses are specific diseases that can only be transmitted through direct contact.

    <p>False</p> Signup and view all the answers

    High levels of herd immunity can significantly increase the risk of infection for vaccinated individuals.

    <p>False</p> Signup and view all the answers

    The terms commensalism and mutualism refer to relationships where both organisms benefit.

    <p>False</p> Signup and view all the answers

    Study Notes

    Learning Objectives: Chapter 16

    • Innate immunity, adaptive immunity, TLRs, pathogen-associated molecular patterns (PAMPs), lysozyme, probiotics, prebiotics, leukocytes, granulocytes (neutrophils, basophils, eosinophils), macrophages, inflammation, vasodilation, edema, histamine, prostaglandins, cytokines, stroma, parenchyma, complement activation, classical pathway, membrane attack complex (MAC) are defined
    • Three examples of PAMPs are identified
    • First and second lines of defense in immunity are described
    • Defensive mechanisms of the eyes, mouth, lungs, urethra, vagina, and colon are outlined, including chemical factors
    • Granulocytes and agranulocytes are compared regarding functions and locations
    • Signs/symptoms, function, and roles of C-reactive protein (CRP) and TNF-α in inflammation are summarized
    • Three stages of inflammation are outlined, referencing Figure 16.8
    • Examples of high, moderate, and low/no regenerative tissue repair are cited
    • Classical complement activation pathway, starting with antibody-antigen binding and creating a transmembrane channel in the bacterial membrane, is detailed

    Mastery-Oriented Student Objectives

    • Roles of CRP, fibroblasts (simulated by cytokines), and damage to blood vessel walls in heart disease (inflammation) are postulated
    • Aspirin and ibuprofen's effects on blood clotting (fibrogen) and prostaglandin production are hypothesized, considering their potential impact on heart disease patients and the immune system regulation

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    Description

    Test your knowledge on Chapter 16 of Immunology, focusing on the mechanisms of innate and adaptive immunity. Explore important concepts such as the roles of different leukocytes, inflammation processes, and defensive strategies of various body systems. This quiz will cover key definitions and examples related to immune responses and tissue repair.

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