35 Questions
Where do components of the immune system originate?
Bone marrow
What is the primary function of dendritic cells in the immune response?
Generation of the immune response
Which type of immunity is conferred by elements available constantly to deal with pathogens?
Innate immunity
Where does the spleen collect antigens from?
Blood
What is the specific immune response mounted by T and B cells in response to?
Almost any foreign antigen
Which of the following is a function of surfactant proteins A & D found in lung fluid?
Binding to and coating the surfaces of pathogens for phagocytosis by macrophages
What is the function of pattern recognition receptors in innate immunity?
Recognize patterns that are common to pathogens
Which of the following is recognized by toll like receptor 4 (TLR4)?
Bacterial lipopolysaccharide (LPS)
What is the role of the macrophage mannose receptor?
Recognizes pathogen surfaces directly
What is the function of scavenger receptors in the immune system?
Recognizing various anionic polymers and low-density lipoproteins on pathogens
What is the primary function of toll like receptors (TLR) in the immune system?
Trigger the induced responses of innate immunity
Which of the following is recognized by mannose-binding lectin receptor?
A particular orientation of certain sugar residues found on microbes
What is the consequence of the activation of TLR4 in the immune system?
Activation of transcription factors and cytokine production
What is the role of toll like receptors (TLRs) in the immune system?
Trigger the production of cytokines, chemokines, and co-stimulatory molecules
What is the primary function of pattern recognition receptors (PRRs) expressed on immune cells?
Recognize foreign antigens and trigger the innate immune response
What is the primary function of mucosal epithelia in innate immunity?
Secrete mucus containing glycoproteins to prevent pathogen adherence
What is a deficiency seen in conditions like cystic fibrosis related to mucosal epithelia?
Failure in expelling pathogens
What is the role of lysozyme and phospholipase A secreted in tears and saliva?
Inhibit growth of pathogens
What is the function of pattern recognition receptors in innate immunity?
Recognize pathogen-associated molecular patterns (PAMPs)
What is the primary role of epithelial barriers in host defense?
Prevent the majority of pathogens from entering the body
What is the consequence of pathogens getting through epithelial barriers?
Activation of innate immune mechanisms in underlying tissue
What is the primary function of phagocytosis in innate immunity?
Engulf and destroy pathogens
What is the function of mucins secreted by mucosal epithelia?
Prevent pathogen adherence to epithelium
What is the primary protective function of epithelial barriers against pathogens?
Physical, chemical, and competitive protection
What is the consequence of a deficiency in the process of expelling pathogens in the flow of mucus?
Increased susceptibility to infections
What is the primary function of lysozyme and phospholipase A secreted in tears and saliva?
Inhibit the growth of pathogens
What is the consequence of a deficiency in the process of expelling pathogens in the flow of mucus?
Increased adherence of pathogens to epithelium
What is the primary function of mucosal epithelia in preventing pathogen colonization?
Secreting mucus to trap pathogens
What is the primary protective function of epithelial barriers against pathogens?
Preventing the majority of pathogens from entering the body
What is the role of pattern recognition receptors (PRRs) in innate immunity?
Recognizing conserved structures on pathogens
Which of the following is a function of pattern recognition receptors (PRRs) expressed on immune cells?
Stimulate ingestion of the pathogen via phagocytosis
What is the role of the macrophage mannose receptor?
Recognizes pathogen surfaces directly
What is recognized by toll like receptor 4 (TLR4)?
Bacterial lipopolysaccharide (LPS)
What is the primary function of surfactant proteins A & D found in lung fluid?
They bind to and coat the surfaces of pathogens for phagocytosis by macrophages
What is the function of scavenger receptors in the immune system?
Recognize various anionic polymers and low-density lipoproteins on pathogens
Test your understanding of the basics of immunology with this quiz covering the concepts of innate and adaptive immunity, including fixed defenses, pattern recognition, complement, dendritic cells, B cells, T cells, and cell communication. This quiz is based on Dr. Christine Loscher's lecture on Innate and Adaptive Immunity from the BE433 course.
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