Podcast
Questions and Answers
The properties of an antibody class are defined by the:
The properties of an antibody class are defined by the:
Fc end of the molecule
Which subset of effector lymphocytes is predominantly responsible for regulation of antibody production?
Which subset of effector lymphocytes is predominantly responsible for regulation of antibody production?
TH12
The primary purpose of neutrophil granules is to:
The primary purpose of neutrophil granules is to:
Provide microbicidal action
T lymphocytes are characterized by all of the following functions EXCEPT which?
T lymphocytes are characterized by all of the following functions EXCEPT which?
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The immunoglobulin molecule is made up of both heavy and light chains - the light chains can be comprised of which of the following?
The immunoglobulin molecule is made up of both heavy and light chains - the light chains can be comprised of which of the following?
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All of the following are applications of real-time PCR, EXCEPT?
All of the following are applications of real-time PCR, EXCEPT?
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Diseases associated with a dysfunction of polymorphonuclear neutrophils (PMNs) include all of the following with the exception of?
Diseases associated with a dysfunction of polymorphonuclear neutrophils (PMNs) include all of the following with the exception of?
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Which of the following is responsible for the humoral immune response?
Which of the following is responsible for the humoral immune response?
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Which of the following types of lymphocytes express CD4?
Which of the following types of lymphocytes express CD4?
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HLA antibodies are responsible for which of the following transfusion reactions?
HLA antibodies are responsible for which of the following transfusion reactions?
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Identify a characteristic of an organ-non-specific disorder that distinguishes it from an organ-specific disorder.
Identify a characteristic of an organ-non-specific disorder that distinguishes it from an organ-specific disorder.
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What section of an immunoglobulin molecule is responsible for the differences between immunoglobulin classes?
What section of an immunoglobulin molecule is responsible for the differences between immunoglobulin classes?
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Which of the following is responsible for causing transfusion associated graft-versus-host disease?
Which of the following is responsible for causing transfusion associated graft-versus-host disease?
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What is the most common early abnormality observed in the lymph nodes of AIDS patients?
What is the most common early abnormality observed in the lymph nodes of AIDS patients?
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All of the following conditions are associated with a polyclonal (broad based) increase in gamma globulins except?
All of the following conditions are associated with a polyclonal (broad based) increase in gamma globulins except?
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Which of the following statements is true regarding anti-nuclear antibodies?
Which of the following statements is true regarding anti-nuclear antibodies?
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What three hepatitis B virus (HBV) early markers are detectable in serum during the first two months after infection?
What three hepatitis B virus (HBV) early markers are detectable in serum during the first two months after infection?
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Which of the following is used to determine if a person has had a recent infection with Strep pyogenes?
Which of the following is used to determine if a person has had a recent infection with Strep pyogenes?
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All of the following would be considered a part of the body's cellular immune system EXCEPT?
All of the following would be considered a part of the body's cellular immune system EXCEPT?
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Which of the following is used as an indicator of inflammation?
Which of the following is used as an indicator of inflammation?
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CD5 antigen is normally found on which of the following lymphocyte populations?
CD5 antigen is normally found on which of the following lymphocyte populations?
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Examples of cytokines originating from activated T-cells include:
Examples of cytokines originating from activated T-cells include:
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What is the expected serological response in an immunocompetent patient who has been vaccinated for hepatitis B?
What is the expected serological response in an immunocompetent patient who has been vaccinated for hepatitis B?
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A 2-month old infant presented with history of chronic diarrhea and failure to thrive. The child's mother also revealed that the baby has suffered from thrush.
A 2-month old infant presented with history of chronic diarrhea and failure to thrive. The child's mother also revealed that the baby has suffered from thrush.
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For the diagnosis of Systemic Lupus Erythematosus (SLE), which of the following test principles provides the highest specificity?
For the diagnosis of Systemic Lupus Erythematosus (SLE), which of the following test principles provides the highest specificity?
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What is the process of monoclonal antibody production?
What is the process of monoclonal antibody production?
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Which of the following antibody types is the predominant serum antibody seen in the secondary immune response?
Which of the following antibody types is the predominant serum antibody seen in the secondary immune response?
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In what trimester is there the greatest risk for the manifestation of complications in maternal rubella infection?
In what trimester is there the greatest risk for the manifestation of complications in maternal rubella infection?
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Skin and mucous membranes are important components of what part of the immune system?
Skin and mucous membranes are important components of what part of the immune system?
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What is the purpose of the Total Complement Activity (CH50) assay?
What is the purpose of the Total Complement Activity (CH50) assay?
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Study Notes
Antibodies and Immune Response
- Properties of an antibody class are determined by its Fc end.
- TH12 effector lymphocytes primarily regulate antibody production.
- Neutrophil granules provide essential microbicidal action.
T-Lymphocytes and Immunoglobulin Structure
- T lymphocytes do NOT synthesize antibodies, distinguishing them from B cells.
- Immunoglobulin molecules consist of heavy and light chains; light chains can be kappa or lambda.
- Differences between immunoglobulin classes arise from variations in heavy chains.
PCR and Immune Disorders
- Real-time PCR is not used for amplifying DNA for northern blot assays.
- Gaucher's disease is not associated with dysfunctions of polymorphonuclear neutrophils (PMNs).
Humoral Immune Response
- B-lymphocytes are responsible for the humoral immune response.
- CD4 is exclusively expressed by T-helper cells.
Transfusion Reactions
- HLA antibodies can lead to transfusion-related acute lung injury (TRALI).
- Transfusion-associated graft-versus-host disease is caused by lymphocytes.
Immunological Disorders and Testing
- Organ-non-specific disorders involve lesions formed by antigen-antibody immune complex deposition.
- Reactive lymphadenopathy is the most common early abnormality in the lymph nodes of AIDS patients.
- A polyclonal increase in gamma globulins is not associated with immunodeficiency.
- 95% of patients with systemic lupus erythematosus (SLE) test positive for anti-nuclear antibodies.
Hepatitis B and Strep Infections
- Early markers for hepatitis B virus infection include HBsAg, HBeAg, and anti-HBc.
- Antistreptolysin O (ASO) is used to detect recent infections with Streptococcus pyogenes.
Cellular Immune System Components
- Thrombocytes (platelets) are not part of the cellular immune system.
- C-reactive protein (CRP) serves as an inflammation indicator.
T-Cell Characteristics and Cytokines
- CD5 antigen is typically found on mature T cell populations.
- Cytokines produced by activated T-cells include IL2 and IL3.
Serological Responses and Vaccination
- A vaccinated immunocompetent patient shows negative HBsAg and anti-HBc, with positive anti-HBs.
- Severe combined immunodeficiency syndrome may present in infants with chronic diarrhea and thrush.
Diagnostics in SLE and Monoclonal Antibodies
- ELISA provides the highest specificity for diagnosing systemic lupus erythematosus (SLE).
- Monoclonal antibody production involves fusing antibody-specific lymphocytes with myeloma cells.
Immunoglobulin Types and Risk Factors
- IgM is the predominant serum antibody in secondary immune responses.
- The first trimester has the highest risk for complications from maternal rubella infections.
Immune System Components
- Skin and mucous membranes are crucial elements of the innate immune system.
- The Total Complement Activity (CH50) assay measures the classic or terminal complement pathway.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on immunology concepts with these flashcards designed for ASCP exam preparation. Each card focuses on key properties of antibodies, lymphocyte functions, and other essential immunological principles. Perfect for exam revision or quick study sessions.
