Podcast
Questions and Answers
What are the two main types of immunity mentioned in the text?
What are the two main types of immunity mentioned in the text?
- Active and Passive
- Humoral and Cell-mediated
- Nonspecific and Specific (correct)
- Inherited and Acquired
Which of the following is NOT a component of the lymphatic system?
Which of the following is NOT a component of the lymphatic system?
- Lymphatic vessels
- Blood vessels (correct)
- Red bone marrow
- Lymph nodes
What is the primary function of the lymphatic system?
What is the primary function of the lymphatic system?
- To transport dietary lipids (correct)
- To regulate body temperature
- To filter waste products from the blood
- To produce red blood cells
Innate immunity is characterized by which of the following?
Innate immunity is characterized by which of the following?
Which of the following statements about adaptive immunity is TRUE?
Which of the following statements about adaptive immunity is TRUE?
What is the main function of lymphatic vessels?
What is the main function of lymphatic vessels?
Which of these is NOT a characteristic of lymphatic capillaries?
Which of these is NOT a characteristic of lymphatic capillaries?
What is the approximate daily volume of fluid that drains into lymphatic vessels?
What is the approximate daily volume of fluid that drains into lymphatic vessels?
Why are lymphatic vessels essential for returning plasma proteins to the bloodstream?
Why are lymphatic vessels essential for returning plasma proteins to the bloodstream?
Which of the following is NOT a principal lymph trunk?
Which of the following is NOT a principal lymph trunk?
Which of these cells are NOT found in the red pulp of the spleen?
Which of these cells are NOT found in the red pulp of the spleen?
What is the primary function of the white pulp in the spleen?
What is the primary function of the white pulp in the spleen?
Which of the following is NOT a function of the spleen?
Which of the following is NOT a function of the spleen?
What is the largest single mass of lymphatic tissue in the body?
What is the largest single mass of lymphatic tissue in the body?
Which of the following components of the spleen is responsible for its structural support?
Which of the following components of the spleen is responsible for its structural support?
Which of the following cells is NOT a product of clonal selection?
Which of the following cells is NOT a product of clonal selection?
What is the main function of the 'effector cell' produced during clonal selection?
What is the main function of the 'effector cell' produced during clonal selection?
Which characteristic of an antigen determines its ability to trigger an immune response?
Which characteristic of an antigen determines its ability to trigger an immune response?
What happens to the effector cells after an immune response is complete?
What happens to the effector cells after an immune response is complete?
What is the role of Major Histocompatibility Complex (MHC) antigens in the immune system?
What is the role of Major Histocompatibility Complex (MHC) antigens in the immune system?
What is meant by the "diversity of antigen receptors" in the immune system?
What is meant by the "diversity of antigen receptors" in the immune system?
What is an epitope?
What is an epitope?
What is the significance of memory cells in the adaptive immune response?
What is the significance of memory cells in the adaptive immune response?
What type of cells are involved in processing and presenting exogenous antigens?
What type of cells are involved in processing and presenting exogenous antigens?
What is the role of MHC-II molecules in exogenous antigen presentation?
What is the role of MHC-II molecules in exogenous antigen presentation?
What is the main difference between endogenous and exogenous antigens?
What is the main difference between endogenous and exogenous antigens?
What is the role of CD4 and CD8 proteins in T cell activation?
What is the role of CD4 and CD8 proteins in T cell activation?
What is the primary function of helper T cells in the immune response?
What is the primary function of helper T cells in the immune response?
What is the importance of costimulation in T cell activation?
What is the importance of costimulation in T cell activation?
What is the primary function of cytotoxic T cells in the immune response?
What is the primary function of cytotoxic T cells in the immune response?
What is the main difference between cytotoxic T cells and NK cells?
What is the main difference between cytotoxic T cells and NK cells?
What are the two main ways cytotoxic T cells kill infected cells?
What are the two main ways cytotoxic T cells kill infected cells?
What is the role of memory B cells in the immune response?
What is the role of memory B cells in the immune response?
What is the function of the variable region of an antibody?
What is the function of the variable region of an antibody?
What is the main difference between plasma cells and memory B cells?
What is the main difference between plasma cells and memory B cells?
Which of the following is NOT a function of antibodies?
Which of the following is NOT a function of antibodies?
What is the role of the complement system in antibody-mediated immunity?
What is the role of the complement system in antibody-mediated immunity?
Which of the following is a correct statement about immunological surveillance?
Which of the following is a correct statement about immunological surveillance?
Which of the following correctly describes the flow of lymph through a lymph node?
Which of the following correctly describes the flow of lymph through a lymph node?
Which of the following structures is NOT a component of the lymph node's stroma?
Which of the following structures is NOT a component of the lymph node's stroma?
What is the primary function of the germinal centers within lymph node follicles?
What is the primary function of the germinal centers within lymph node follicles?
Which of the following cells are primarily found in the inner cortex of a lymph node?
Which of the following cells are primarily found in the inner cortex of a lymph node?
Which of the following statements accurately describes the relationship between lymph nodes and the lymphatic stream?
Which of the following statements accurately describes the relationship between lymph nodes and the lymphatic stream?
Which of the following is NOT a function of the lymphatic system?
Which of the following is NOT a function of the lymphatic system?
How do macrophages contribute to the filtering function of lymph nodes?
How do macrophages contribute to the filtering function of lymph nodes?
In what region of the lymph node would you expect to find a high concentration of antibody-producing plasma cells?
In what region of the lymph node would you expect to find a high concentration of antibody-producing plasma cells?
Flashcards
Immunity
Immunity
The ability to ward off damage or disease through defenses.
Types of Immunity
Types of Immunity
Two types: innate (nonspecific) and adaptive (specific).
Innate Immunity
Innate Immunity
Nonspecific immunity present at birth; no memory of invaders.
Adaptive Immunity
Adaptive Immunity
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Functions of the Lymphatic System
Functions of the Lymphatic System
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Lymphatic System
Lymphatic System
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Lymphatic Capillaries
Lymphatic Capillaries
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Lymph Trunks
Lymph Trunks
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Formation of Lymph
Formation of Lymph
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Venous Return Pumps
Venous Return Pumps
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Spleen
Spleen
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White pulp
White pulp
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Red pulp
Red pulp
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Functions of the spleen
Functions of the spleen
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Macrophages in the spleen
Macrophages in the spleen
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Lymph Nodes
Lymph Nodes
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Stroma
Stroma
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Parenchyma
Parenchyma
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Cortex
Cortex
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Medulla
Medulla
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Afferent Lymphatic Vessels
Afferent Lymphatic Vessels
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Filtration Function
Filtration Function
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Immune System Activation
Immune System Activation
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Clonal Selection
Clonal Selection
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Clone (in immunology)
Clone (in immunology)
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Effector Cell
Effector Cell
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Memory Cell
Memory Cell
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Immunogenicity
Immunogenicity
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Reactivity
Reactivity
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Epitope
Epitope
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Major Histocompatibility Complex (MHC) Antigens
Major Histocompatibility Complex (MHC) Antigens
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B cells
B cells
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T cells
T cells
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Antigen processing
Antigen processing
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APC (Antigen Presenting Cell)
APC (Antigen Presenting Cell)
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Exogenous antigens
Exogenous antigens
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Endogenous antigens
Endogenous antigens
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MHC molecules
MHC molecules
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Costimulation
Costimulation
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Clonal selection of T cells
Clonal selection of T cells
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Memory T cells
Memory T cells
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B cell activation
B cell activation
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Antibodies
Antibodies
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Plasma cells
Plasma cells
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Cytotoxic T cells
Cytotoxic T cells
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Phagocytosis
Phagocytosis
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Study Notes
Lymphatic System
- The lymphatic system is composed of lymph, lymphatic vessels, structures, and organs containing lymphatic tissue, red bone marrow
- It functions to drain excess interstitial fluid, transport dietary lipid, and carry out immune responses
- Lymphatic vessels begin as lymphatic capillaries, which are closed at one end and resemble veins in structure but have thinner walls and more valves
- Lymph flows through the lymphatic system in one direction, entering through afferent lymphatic vessels, traversing lymph nodes and sinuses (irregular channels), exiting via efferent lymphatic vessels
- Lymphatic vessels pass through lymph nodes and encapsulated organs with masses of B and T cells
- Lymph capillaries have a slightly larger diameter than blood capillaries, a unique one-way structure, and anchoring filaments that widen openings when interstitial fluid builds up
- Lymph trunks and ducts collect the lymph from different regions of the body and drain it into venous blood
- Two main channels, thoracic and right lymphatic, receive collected lymph from the trunks
- Important components of the lymphatic system include lymph nodes, the spleen, lymphatic nodules, and the tonsils
- Lymph nodes function as filters, removing foreign materials
- The spleen filters blood and carries out immune function. The spleen is composed of white pulp, lymphatic tissue containing lymphocytes and macrophages, and red pulp, blood-filled venous sinuses, splenic cords, red blood cells, macrophages, lymphocytes, plasma cells, and granulocytes.
- Lymphatic nodules are scattered through lamina propria of mucous membranes lining the gastrointestinal, urinary, and reproductive tracts, and are part of the mucosa-associated lymphatic tissue.
Immunity
- Immunity, either innate or adaptive, is the ability to ward off damage or disease through our defenses
- Innate immunity ("non-specific") is present at birth and has no specific recognition of invaders or memory component. It has 1st and 2nd lines of defense.
- Adaptive immunity ("specific") is acquired, recognizes foreign invaders specifically, and has a memory component
- Two main types of cells participate in adaptive immunity:
- T-cells: manage the immune response and attack/destroy foreign cells
- B-cells: produce plasma cells, secreting antibodies that immobilize antigens
- Other lymphoid cells:
- Macrophages: phagocytize foreign substances
- Dendritic cells: resemble macrophages and capture antigens
- Reticular cells: fibroblast-like cells supporting other lymphoid cells
Lymphoid Organs
- Primary lymphatic organs produce immunocompetent cells (to produce a normal immune response): red bone marrow and thymus
- Secondary lymphatic organs are locations where immune responses occur: lymph nodes, spleen, lymphatic nodules.
Lymphatic Organs (details)
- Thymus: Located in the thorax. Thymic lobes contain an outer cortex and inner medulla; cortex has densely packed lymphocytes and scattered macrophages; medulla contains fewer lymphocytes and Hassall's corpuscles
- Lymph Nodes: Bean-shaped structures in lymphatic vessels; have a cortex and medulla. The cortex has lymphatic nodules where B-cells are; inner cortex has T cells and dendritic cells; medulla contains B-cells, plasma cells and macrophages
- Spleen: Largest lymphatic tissue. Stroma (framework) is capsule, trabeculae, reticular fibers, and fibroblasts. Parenchyma is white pulp (lymphocytes and macrophages; B and T cells function) and red pulp (blood-filled venous sinuses, splenic cords; macrophages remove defective RBCs, storage of platelets)
- Lymphatic nodules: Not encapsulated; found in lamina propria of mucous membranes of GI tract, respiratory tract, tonsils, Peyer's patches, appendix
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