Immunology and Lymphatic System Quiz

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Questions and Answers

What are the two main types of immunity mentioned in the text?

  • Active and Passive
  • Humoral and Cell-mediated
  • Nonspecific and Specific (correct)
  • Inherited and Acquired

Which of the following is NOT a component of the lymphatic system?

  • Lymphatic vessels
  • Blood vessels (correct)
  • Red bone marrow
  • Lymph nodes

What is the primary function of the lymphatic system?

  • To transport dietary lipids (correct)
  • To regulate body temperature
  • To filter waste products from the blood
  • To produce red blood cells

Innate immunity is characterized by which of the following?

<p>First and second lines of defense (D)</p> Signup and view all the answers

Which of the following statements about adaptive immunity is TRUE?

<p>It is responsible for recognizing specific invaders. (B)</p> Signup and view all the answers

What is the main function of lymphatic vessels?

<p>To return excess interstitial fluid and proteins to the bloodstream (B)</p> Signup and view all the answers

Which of these is NOT a characteristic of lymphatic capillaries?

<p>They permit interstitial fluid to flow out, but not in. (D)</p> Signup and view all the answers

What is the approximate daily volume of fluid that drains into lymphatic vessels?

<p>3 liters (C)</p> Signup and view all the answers

Why are lymphatic vessels essential for returning plasma proteins to the bloodstream?

<p>Proteins are too large to be reabsorbed by blood capillaries. (B)</p> Signup and view all the answers

Which of the following is NOT a principal lymph trunk?

<p>Splenic (C)</p> Signup and view all the answers

Which of these cells are NOT found in the red pulp of the spleen?

<p>Osteoblasts (D)</p> Signup and view all the answers

What is the primary function of the white pulp in the spleen?

<p>Immune surveillance and response (C)</p> Signup and view all the answers

Which of the following is NOT a function of the spleen?

<p>Production of hormones that regulate blood pressure (B)</p> Signup and view all the answers

What is the largest single mass of lymphatic tissue in the body?

<p>Spleen (A)</p> Signup and view all the answers

Which of the following components of the spleen is responsible for its structural support?

<p>Stroma (C)</p> Signup and view all the answers

Which of the following cells is NOT a product of clonal selection?

<p>Red Blood Cell (B)</p> Signup and view all the answers

What is the main function of the 'effector cell' produced during clonal selection?

<p>To eliminate or inactivate the antigen (D)</p> Signup and view all the answers

Which characteristic of an antigen determines its ability to trigger an immune response?

<p>Immunogenicity (D)</p> Signup and view all the answers

What happens to the effector cells after an immune response is complete?

<p>They are destroyed (D)</p> Signup and view all the answers

What is the role of Major Histocompatibility Complex (MHC) antigens in the immune system?

<p>To help T cells recognize foreign or self-antigens (D)</p> Signup and view all the answers

What is meant by the "diversity of antigen receptors" in the immune system?

<p>The ability of the immune system to recognize and bind to a variety of different antigens (D)</p> Signup and view all the answers

What is an epitope?

<p>A specific region on an antigen that is recognized by the immune system (A)</p> Signup and view all the answers

What is the significance of memory cells in the adaptive immune response?

<p>They allow for a faster and more efficient response to subsequent exposures to the same antigen (B)</p> Signup and view all the answers

What type of cells are involved in processing and presenting exogenous antigens?

<p>All of the above (D)</p> Signup and view all the answers

What is the role of MHC-II molecules in exogenous antigen presentation?

<p>MHC-II molecules bind to peptide fragments of exogenous antigens and present them to T cells. (A)</p> Signup and view all the answers

What is the main difference between endogenous and exogenous antigens?

<p>Endogenous antigens are found inside body cells, while exogenous antigens are found outside body cells. (B)</p> Signup and view all the answers

What is the role of CD4 and CD8 proteins in T cell activation?

<p>CD4 and CD8 proteins bind to MHC-I and MHC-II molecules, respectively, to trigger T cell activation. (C)</p> Signup and view all the answers

What is the primary function of helper T cells in the immune response?

<p>Helper T cells activate other immune cells, such as cytotoxic T cells and B cells. (D)</p> Signup and view all the answers

What is the importance of costimulation in T cell activation?

<p>Costimulation ensures that T cells are activated only when there is a genuine threat to the body. (D)</p> Signup and view all the answers

What is the primary function of cytotoxic T cells in the immune response?

<p>Cytotoxic T cells directly kill infected cells. (A)</p> Signup and view all the answers

What is the main difference between cytotoxic T cells and NK cells?

<p>Cytotoxic T cells are specific for a particular antigen, while NK cells can destroy a wide variety of infected cells. (D)</p> Signup and view all the answers

What are the two main ways cytotoxic T cells kill infected cells?

<p>Cytotoxic T cells release cytotoxic granules containing perforin and granzymes, which cause cell lysis and apoptosis, respectively. (B)</p> Signup and view all the answers

What is the role of memory B cells in the immune response?

<p>Memory B cells provide a rapid response to a previously encountered antigen. (B)</p> Signup and view all the answers

What is the function of the variable region of an antibody?

<p>The variable region binds to specific epitopes on antigens. (A)</p> Signup and view all the answers

What is the main difference between plasma cells and memory B cells?

<p>Plasma cells produce antibodies, while memory B cells do not. (C), Plasma cells are short-lived, while memory B cells are long-lived. (D)</p> Signup and view all the answers

Which of the following is NOT a function of antibodies?

<p>Activating T cells (B)</p> Signup and view all the answers

What is the role of the complement system in antibody-mediated immunity?

<p>The complement system helps in the removal of antibody-antigen complexes. (B)</p> Signup and view all the answers

Which of the following is a correct statement about immunological surveillance?

<p>Immunological surveillance involves the activity of cytotoxic T cells, macrophages, and natural killer cells. (D)</p> Signup and view all the answers

Which of the following correctly describes the flow of lymph through a lymph node?

<p>Lymph enters through afferent lymphatic vessels and exits through efferent lymphatic vessels. (D)</p> Signup and view all the answers

Which of the following structures is NOT a component of the lymph node's stroma?

<p>Lymphatic nodules (C)</p> Signup and view all the answers

What is the primary function of the germinal centers within lymph node follicles?

<p>Proliferation of B cells (D)</p> Signup and view all the answers

Which of the following cells are primarily found in the inner cortex of a lymph node?

<p>T cells (B)</p> Signup and view all the answers

Which of the following statements accurately describes the relationship between lymph nodes and the lymphatic stream?

<p>Lymph nodes are part of the lymphatic stream, serving as filtration points. (D)</p> Signup and view all the answers

Which of the following is NOT a function of the lymphatic system?

<p>Production of red blood cells (C)</p> Signup and view all the answers

How do macrophages contribute to the filtering function of lymph nodes?

<p>Macrophages engulf and destroy microorganisms and debris. (A)</p> Signup and view all the answers

In what region of the lymph node would you expect to find a high concentration of antibody-producing plasma cells?

<p>Medulla (D)</p> Signup and view all the answers

Flashcards

Immunity

The ability to ward off damage or disease through defenses.

Types of Immunity

Two types: innate (nonspecific) and adaptive (specific).

Innate Immunity

Nonspecific immunity present at birth; no memory of invaders.

Adaptive Immunity

Specific immunity that recognizes invaders and has a memory component.

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Functions of the Lymphatic System

Drains excess fluid, transports dietary lipids, and houses immune cells.

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Lymphatic System

A system that carries immune responses and drains excess fluid from tissues.

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Lymphatic Capillaries

Small, closed-end vessels that allow interstitial fluid to enter but not exit.

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Lymph Trunks

Large vessels formed from lymphatic capillaries, leading to ducts for drainage.

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Formation of Lymph

Excess fluid from blood capillaries becomes lymph, about 3L/day.

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Venous Return Pumps

Skeletal muscle and respiratory pumps that aid lymph movement back to blood.

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Spleen

The largest single mass of lymphatic tissue in the body, involved in immune responses and filtration of blood.

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White pulp

A component of the spleen rich in lymphatic tissue that contains lymphocytes and macrophages functioning in immune response.

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Red pulp

The area in the spleen filled with blood venous sinuses and responsible for filtering blood and recycling blood cells.

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Functions of the spleen

Includes lymphocyte proliferation, immune response, blood cleansing, storage of blood components, and fetal blood cell production.

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Macrophages in the spleen

Cells that remove defective blood cells and salvage iron for reuse by bone marrow.

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Lymph Nodes

Small, bean-shaped structures located along lymphatic vessels throughout the body.

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Stroma

Supporting connective tissue in lymph nodes, including capsule, trabeculae, reticular fibers, and fibroblasts.

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Parenchyma

The functional part of lymph nodes, divided into cortex and medulla.

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Cortex

Outer region of a lymph node containing B cell aggregates called lymphatic nodules.

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Medulla

Inner region of a lymph node consisting of B cells, plasma cells, and macrophages.

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Afferent Lymphatic Vessels

Vessels that bring lymph into the lymph node for processing.

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Filtration Function

Lymph nodes trap foreign substances and destroy them via macrophages.

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Immune System Activation

Lymph nodes monitor for antigens and initiate an immune response when necessary.

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Clonal Selection

Process where a lymphocyte proliferates and differentiates in response to a specific antigen.

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Clone (in immunology)

Population of identical cells recognizing the same antigen as the original cell.

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Effector Cell

Cells that actively respond to an antigen, including activated T or plasma cells, typically dying after the immune response.

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Memory Cell

Cells that remain inactive during the initial response but proliferate upon re-exposure to the same antigen.

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Immunogenicity

Ability of an antigen to provoke an immune response.

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Reactivity

Ability of an antigen to specifically react with antibodies it provoked.

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Epitope

The specific part of an antigen that is recognized by the immune system; also known as antigenic determinant.

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Major Histocompatibility Complex (MHC) Antigens

Self-antigens that help T cells recognize foreign entities or self, located on cell surfaces.

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B cells

Immune cells that bind directly to antigens in body fluids.

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T cells

Immune cells that require processed antigen fragments for recognition.

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Antigen processing

Breakdown of antigenic proteins into peptide fragments associated with MHC molecules.

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APC (Antigen Presenting Cell)

Cells that process and present antigens such as dendritic cells, macrophages, and B cells.

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Exogenous antigens

Antigens found in body fluids outside of body cells.

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Endogenous antigens

Antigens that originate from within body cells.

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MHC molecules

Major Histocompatibility Complex molecules that present antigen fragments to T cells.

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Costimulation

A second signal required for T cell activation, often provided by cytokines.

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Clonal selection of T cells

Activation process resulting in the proliferation of specific T cells in response to an antigen.

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Memory T cells

T cells that remain inactive after an immune response but can quickly activate upon re-exposure to the same antigen.

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B cell activation

Process where B cells respond to antigens, often requiring helper T cell assistance.

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Antibodies

Proteins produced by plasma cells that specifically bind to antigens.

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Plasma cells

B cells that have been activated and are responsible for producing antibodies.

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Cytotoxic T cells

T cells that directly attack and destroy infected body cells.

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Phagocytosis

The process by which certain immune cells engulf and digest foreign substances.

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Study Notes

Lymphatic System

  • The lymphatic system is composed of lymph, lymphatic vessels, structures, and organs containing lymphatic tissue, red bone marrow
  • It functions to drain excess interstitial fluid, transport dietary lipid, and carry out immune responses
  • Lymphatic vessels begin as lymphatic capillaries, which are closed at one end and resemble veins in structure but have thinner walls and more valves
  • Lymph flows through the lymphatic system in one direction, entering through afferent lymphatic vessels, traversing lymph nodes and sinuses (irregular channels), exiting via efferent lymphatic vessels
  • Lymphatic vessels pass through lymph nodes and encapsulated organs with masses of B and T cells
  • Lymph capillaries have a slightly larger diameter than blood capillaries, a unique one-way structure, and anchoring filaments that widen openings when interstitial fluid builds up
  • Lymph trunks and ducts collect the lymph from different regions of the body and drain it into venous blood
  • Two main channels, thoracic and right lymphatic, receive collected lymph from the trunks
  • Important components of the lymphatic system include lymph nodes, the spleen, lymphatic nodules, and the tonsils
  • Lymph nodes function as filters, removing foreign materials
  • The spleen filters blood and carries out immune function. The spleen is composed of white pulp, lymphatic tissue containing lymphocytes and macrophages, and red pulp, blood-filled venous sinuses, splenic cords, red blood cells, macrophages, lymphocytes, plasma cells, and granulocytes.
  • Lymphatic nodules are scattered through lamina propria of mucous membranes lining the gastrointestinal, urinary, and reproductive tracts, and are part of the mucosa-associated lymphatic tissue.

Immunity

  • Immunity, either innate or adaptive, is the ability to ward off damage or disease through our defenses
  • Innate immunity ("non-specific") is present at birth and has no specific recognition of invaders or memory component. It has 1st and 2nd lines of defense.
  • Adaptive immunity ("specific") is acquired, recognizes foreign invaders specifically, and has a memory component
  • Two main types of cells participate in adaptive immunity:
  • T-cells: manage the immune response and attack/destroy foreign cells
  • B-cells: produce plasma cells, secreting antibodies that immobilize antigens
  • Other lymphoid cells:
    • Macrophages: phagocytize foreign substances
    • Dendritic cells: resemble macrophages and capture antigens
    • Reticular cells: fibroblast-like cells supporting other lymphoid cells

Lymphoid Organs

  • Primary lymphatic organs produce immunocompetent cells (to produce a normal immune response): red bone marrow and thymus
  • Secondary lymphatic organs are locations where immune responses occur: lymph nodes, spleen, lymphatic nodules.

Lymphatic Organs (details)

  • Thymus: Located in the thorax. Thymic lobes contain an outer cortex and inner medulla; cortex has densely packed lymphocytes and scattered macrophages; medulla contains fewer lymphocytes and Hassall's corpuscles
  • Lymph Nodes: Bean-shaped structures in lymphatic vessels; have a cortex and medulla. The cortex has lymphatic nodules where B-cells are; inner cortex has T cells and dendritic cells; medulla contains B-cells, plasma cells and macrophages
  • Spleen: Largest lymphatic tissue. Stroma (framework) is capsule, trabeculae, reticular fibers, and fibroblasts. Parenchyma is white pulp (lymphocytes and macrophages; B and T cells function) and red pulp (blood-filled venous sinuses, splenic cords; macrophages remove defective RBCs, storage of platelets)
  • Lymphatic nodules: Not encapsulated; found in lamina propria of mucous membranes of GI tract, respiratory tract, tonsils, Peyer's patches, appendix

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