17 Questions
What is the principle underlying immunodiagnosis of disease?
Direct detection of antigens in clinical specimens
In which application is antigen detection commonly used?
ID of microorganisms
What does serology testing involve the detection of?
Antibodies in patient serum
Which component of serology testing involves specimen collection and transport?
Pre-Analytical
What is an example of a post-analytical potential error in serology testing?
Transcription & Log
For which organisms is serology testing especially useful when they are difficult to isolate through culture?
Viruses
What is the significance of positive IgM without IgG in a serological test?
No infection or it is extremely early in infection
What does a four-fold rise in antibody titer between the acute and convalescent phases indicate?
The patient is recovering from the infection
In serology testing, what is the significance of the zone of equivalence?
It depicts the point where reactions are detectable
What is a common cause of false negative results in serology testing?
Prozone
What does a compound dilution of 1:500 indicate in serology testing?
A very low antigen concentration
What does the presence of IgG without IgM in a serological test indicate?
Past infection
What does a rapid increase to a higher level of IgG after a secondary antibody response indicate?
The patient has mounted a strong immune response
What does a high level of IgM without IgG in a serological test indicate?
Very recent infection or vaccination
What is the significance of positive IgG without IgM in a serological test?
Past infection
What does a gradual decline of IgG to undetectable levels over several months indicate?
The patient has not been infected
What does a high level of IgG without IgM in a serological test indicate?
Past infection
Test your knowledge of immunologic methods and immunodiagnosis of diseases, including the principles of antigen-antibody reactions, direct detection of antigens in clinical specimens, and detection of antibodies in patient serum.
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