5 Questions
What is the basic principle of immunocytochemistry?
Demonstrating the specific antigen in the cell by applying the corresponding antibody to have antigen-antibody reaction
What evokes a specific immunologic response to develop an antibody?
Antigen epitope site
What does IHC make possible?
Visualize the distribution and localization of specific cellular components within a cell or tissue
What is the technique to visualize the recognition of antigens present in the tissue?
Immunohistochemistry (IHC)/immunocytochemistry (ICC)
What do the antigen epitope site and antibody binding site have?
Complementary geometrical and chemical features
Study Notes
Immunocytochemistry Basics
- The basic principle of immunocytochemistry is the specific binding of antibodies to antigens in tissue sections, allowing the visualization of specific proteins or other biomolecules.
Immunologic Response
- A specific immunologic response is evoked by the presence of an antigen, which triggers the development of an antibody.
Immunohistochemistry (IHC)
- IHC makes possible the detection of specific proteins or biomolecules in tissue sections.
Antigen-Antibody Binding
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The technique to visualize the recognition of antigens present in the tissue is based on the binding of an antibody to a specific epitope site on the antigen.
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The antigen epitope site and antibody binding site are complementary, enabling specific binding between the two.
Test your knowledge of immunohistochemistry and tumor markers with this quiz. Explore the techniques and principles behind visualizing tissue antigens using antibodies and the identification of specific tissue components.
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