Podcast
Questions and Answers
Which process is employed to generate a diverse repertoire of both B cells and T cells?
Which process is employed to generate a diverse repertoire of both B cells and T cells?
What is the purpose of this afternoon's lecture?
What is the purpose of this afternoon's lecture?
Which cells undergo BTJ recombination?
Which cells undergo BTJ recombination?
Is knowledge of detailed molecular biology required for this lecture?
Is knowledge of detailed molecular biology required for this lecture?
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What is the process called that occurs in B cells and further diversifies them?
What is the process called that occurs in B cells and further diversifies them?
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What process is responsible for selecting the best B cells to identify and recognize an antigen?
What process is responsible for selecting the best B cells to identify and recognize an antigen?
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Which part of the B cell receptor is modified during class switch recombination?
Which part of the B cell receptor is modified during class switch recombination?
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What is the purpose of BTJ recombination in ensuring recognition of antigens?
What is the purpose of BTJ recombination in ensuring recognition of antigens?
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Which enzyme catalyzes the rearrangement of the germline sequence in the T cell receptor?
Which enzyme catalyzes the rearrangement of the germline sequence in the T cell receptor?
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What is the purpose of somatic host mutation in B cells?
What is the purpose of somatic host mutation in B cells?
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What are the specific sites on the DNA where rearrangement occurs called?
What are the specific sites on the DNA where rearrangement occurs called?
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What is the purpose of terminal deoxy transferase in the rearrangement process?
What is the purpose of terminal deoxy transferase in the rearrangement process?
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Which type of immunoglobulin is needed when the antigen is in the bloodstream?
Which type of immunoglobulin is needed when the antigen is in the bloodstream?
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What is the process called when immune globulin binds to a pathogen to flag it to a macrophage?
What is the process called when immune globulin binds to a pathogen to flag it to a macrophage?
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Which part of the B cell receptor is altered during class switch recombination?
Which part of the B cell receptor is altered during class switch recombination?
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What enzyme is critical in both somatic hypermutation and class switch recombination?
What enzyme is critical in both somatic hypermutation and class switch recombination?
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What is the process called when B cells introduce random genetic alterations in their B cell receptor followed by antigenic challenge?
What is the process called when B cells introduce random genetic alterations in their B cell receptor followed by antigenic challenge?
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What happens to B cells that do not recognize the antigen better after somatic hypermutation?
What happens to B cells that do not recognize the antigen better after somatic hypermutation?
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Where does somatic hypermutation and affinity maturation primarily take place?
Where does somatic hypermutation and affinity maturation primarily take place?
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What happens to B cells that recognize the antigen with higher affinity after somatic hypermutation?
What happens to B cells that recognize the antigen with higher affinity after somatic hypermutation?
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Which of the following best describes the purpose of the molecular cutting and shutting off the immune globulin?
Which of the following best describes the purpose of the molecular cutting and shutting off the immune globulin?
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What is the relationship between the IG M or MU locus and the IG locus?
What is the relationship between the IG M or MU locus and the IG locus?
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What drives or guides the class switch recombination event?
What drives or guides the class switch recombination event?
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Why does class switch recombination matter?
Why does class switch recombination matter?
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What is the main goal of achieving a better molecule or molecular structure?
What is the main goal of achieving a better molecule or molecular structure?
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Which region of the immune globulin molecule is good at neutralizing and optimizing?
Which region of the immune globulin molecule is good at neutralizing and optimizing?
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What is the enzyme predominantly used for introducing mutations in B cells?
What is the enzyme predominantly used for introducing mutations in B cells?
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What is the mutation rate at the immunoglobulin loci compared to other loci in the genome?
What is the mutation rate at the immunoglobulin loci compared to other loci in the genome?
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What is the purpose of somatic hypermutation in B cells?
What is the purpose of somatic hypermutation in B cells?
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What is the specific base that is mutated in somatic hypermutation?
What is the specific base that is mutated in somatic hypermutation?
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Which enzyme is responsible for catalyzing the rearrangement of the germline sequence in the T cell receptor?
Which enzyme is responsible for catalyzing the rearrangement of the germline sequence in the T cell receptor?
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What is the primary purpose of V(D)J recombination?
What is the primary purpose of V(D)J recombination?
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Which segments of the immune cell receptor genes are involved in V(D)J recombination?
Which segments of the immune cell receptor genes are involved in V(D)J recombination?
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How many possible combinations of immune cell receptor sequences can be generated through V(D)J recombination?
How many possible combinations of immune cell receptor sequences can be generated through V(D)J recombination?
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Which Recombination Activating Genes (RAGs) are critical for the cleavage stage of V(D)J joining?
Which Recombination Activating Genes (RAGs) are critical for the cleavage stage of V(D)J joining?
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Which specific sites on the DNA are involved in rearrangement during V(D)J joining?
Which specific sites on the DNA are involved in rearrangement during V(D)J joining?
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What is the purpose of terminal deoxynucleotidyl transferase (Tdt) in V(D)J rearrangement?
What is the purpose of terminal deoxynucleotidyl transferase (Tdt) in V(D)J rearrangement?
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Which type of immune cell undergoes VJ recombination?
Which type of immune cell undergoes VJ recombination?
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Where does somatic hypermutation and affinity maturation primarily take place?
Where does somatic hypermutation and affinity maturation primarily take place?
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What is the purpose of antibody class switching?
What is the purpose of antibody class switching?
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Which cells are subject to Darwinian selection resulting in a 'better' B cell for specific antigen recognition and response?
Which cells are subject to Darwinian selection resulting in a 'better' B cell for specific antigen recognition and response?
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What is the process by which B cells produce antibodies with increased affinity for antigen during an immune response?
What is the process by which B cells produce antibodies with increased affinity for antigen during an immune response?
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What is the enzyme responsible for introducing point mutations during somatic hypermutation?
What is the enzyme responsible for introducing point mutations during somatic hypermutation?
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What is the first targeted switch region in class switch recombination?
What is the first targeted switch region in class switch recombination?
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What determines the partner switch region in class switch recombination?
What determines the partner switch region in class switch recombination?
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What is the main goal of somatic hypermutation and affinity maturation?
What is the main goal of somatic hypermutation and affinity maturation?
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What is the purpose of class switch recombination?
What is the purpose of class switch recombination?
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What is the mutation rate during somatic hypermutation compared to normal cell division?
What is the mutation rate during somatic hypermutation compared to normal cell division?
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What is the enzyme critical for both somatic hypermutation and class switch recombination?
What is the enzyme critical for both somatic hypermutation and class switch recombination?
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What is the purpose of affinity maturation?
What is the purpose of affinity maturation?
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What is the primary goal of somatic hypermutation and affinity maturation?
What is the primary goal of somatic hypermutation and affinity maturation?
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What is the role of follicular dendritic cells in affinity maturation?
What is the role of follicular dendritic cells in affinity maturation?
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What is the mutation rate during somatic hypermutation compared to normal cell division?
What is the mutation rate during somatic hypermutation compared to normal cell division?
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What is the purpose of class switch recombination?
What is the purpose of class switch recombination?
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What determines the partner switch region in class switch recombination?
What determines the partner switch region in class switch recombination?
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What happens to B cells that have undergone somatic hypermutation but bind antigens with lower affinity?
What happens to B cells that have undergone somatic hypermutation but bind antigens with lower affinity?
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What is the role of activation-induced cytidine deaminase (AID) in class switch recombination?
What is the role of activation-induced cytidine deaminase (AID) in class switch recombination?
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What happens to B cells that do not recognize the antigen better after somatic hypermutation?
What happens to B cells that do not recognize the antigen better after somatic hypermutation?
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What is the relationship between somatic hypermutation and affinity maturation?
What is the relationship between somatic hypermutation and affinity maturation?
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What is the purpose of introducing genetic alterations in B cell receptors during somatic hypermutation?
What is the purpose of introducing genetic alterations in B cell receptors during somatic hypermutation?
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