T1 L5: Adaptive immunity 2 (CP)

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Questions and Answers

Which process is employed to generate a diverse repertoire of both B cells and T cells?

  • Diversification and selection
  • Molecular biology process
  • Adaptive immunity
  • BTJ recombination (correct)

What is the purpose of this afternoon's lecture?

  • To provide a detailed exposition of molecular biology
  • To discuss the process of BTJ recombination
  • To explain diversification and selection of diversified adaptive cells (correct)
  • To introduce the adaptive immune system

Which cells undergo BTJ recombination?

  • B cells and T cells (correct)
  • Only B cells
  • Only T cells
  • None of the above

Is knowledge of detailed molecular biology required for this lecture?

<p>No, it is not required (A)</p> Signup and view all the answers

What is the process called that occurs in B cells and further diversifies them?

<p>Somatic hyper mutation (C)</p> Signup and view all the answers

What process is responsible for selecting the best B cells to identify and recognize an antigen?

<p>Affinity maturation (A)</p> Signup and view all the answers

Which part of the B cell receptor is modified during class switch recombination?

<p>The constant region (D)</p> Signup and view all the answers

What is the purpose of BTJ recombination in ensuring recognition of antigens?

<p>To splice together variable, diversity, and adjoining regions (D)</p> Signup and view all the answers

Which enzyme catalyzes the rearrangement of the germline sequence in the T cell receptor?

<p>Recombination Activating Genes (A)</p> Signup and view all the answers

What is the purpose of somatic host mutation in B cells?

<p>To further diversify the B cell pool (D)</p> Signup and view all the answers

What are the specific sites on the DNA where rearrangement occurs called?

<p>RSSs (C)</p> Signup and view all the answers

What is the purpose of terminal deoxy transferase in the rearrangement process?

<p>To splice the DNA fragments together (A)</p> Signup and view all the answers

Which type of immunoglobulin is needed when the antigen is in the bloodstream?

<p>IgG (C)</p> Signup and view all the answers

What is the process called when immune globulin binds to a pathogen to flag it to a macrophage?

<p>Optimization (C)</p> Signup and view all the answers

Which part of the B cell receptor is altered during class switch recombination?

<p>The constant region of the heavy chain (C)</p> Signup and view all the answers

What enzyme is critical in both somatic hypermutation and class switch recombination?

<p>Activation-induced cytidine deaminase (C)</p> Signup and view all the answers

What is the process called when B cells introduce random genetic alterations in their B cell receptor followed by antigenic challenge?

<p>Somatic hypermutation (A)</p> Signup and view all the answers

What happens to B cells that do not recognize the antigen better after somatic hypermutation?

<p>They undergo apoptosis (D)</p> Signup and view all the answers

Where does somatic hypermutation and affinity maturation primarily take place?

<p>Germinal center (D)</p> Signup and view all the answers

What happens to B cells that recognize the antigen with higher affinity after somatic hypermutation?

<p>They are selected for (C)</p> Signup and view all the answers

Which of the following best describes the purpose of the molecular cutting and shutting off the immune globulin?

<p>To generate alternative transcripts (D)</p> Signup and view all the answers

What is the relationship between the IG M or MU locus and the IG locus?

<p>They are alternative versions of each other (C)</p> Signup and view all the answers

What drives or guides the class switch recombination event?

<p>Cytokines (C)</p> Signup and view all the answers

Why does class switch recombination matter?

<p>Different constant regions of the immune globulin molecule perform different functions (B)</p> Signup and view all the answers

What is the main goal of achieving a better molecule or molecular structure?

<p>To suit the type of pathogen and eradicate it effectively (B)</p> Signup and view all the answers

Which region of the immune globulin molecule is good at neutralizing and optimizing?

<p>IgG (B)</p> Signup and view all the answers

What is the enzyme predominantly used for introducing mutations in B cells?

<p>Activation induced sighting deaminase (B)</p> Signup and view all the answers

What is the mutation rate at the immunoglobulin loci compared to other loci in the genome?

<p>About a million times higher (C)</p> Signup and view all the answers

What is the purpose of somatic hypermutation in B cells?

<p>To introduce further diversification (A)</p> Signup and view all the answers

What is the specific base that is mutated in somatic hypermutation?

<p>Cytosine (C)</p> Signup and view all the answers

Which enzyme is responsible for catalyzing the rearrangement of the germline sequence in the T cell receptor?

<p>RAG-1 (A)</p> Signup and view all the answers

What is the primary purpose of V(D)J recombination?

<p>To generate diversity of antigen recognition and response (A)</p> Signup and view all the answers

Which segments of the immune cell receptor genes are involved in V(D)J recombination?

<p>Variable, Diversity, and Joining segments (C)</p> Signup and view all the answers

How many possible combinations of immune cell receptor sequences can be generated through V(D)J recombination?

<p>Approximately 1018 (A)</p> Signup and view all the answers

Which Recombination Activating Genes (RAGs) are critical for the cleavage stage of V(D)J joining?

<p>RAG-1 and RAG-2 (A)</p> Signup and view all the answers

Which specific sites on the DNA are involved in rearrangement during V(D)J joining?

<p>Recombination Signal Sequences (RSSs) (A)</p> Signup and view all the answers

What is the purpose of terminal deoxynucleotidyl transferase (Tdt) in V(D)J rearrangement?

<p>To introduce additional diversity through the addition of random nucleotides (C)</p> Signup and view all the answers

Which type of immune cell undergoes VJ recombination?

<p>B cells (C)</p> Signup and view all the answers

Where does somatic hypermutation and affinity maturation primarily take place?

<p>In the germinal centers of secondary lymphoid organs (C)</p> Signup and view all the answers

What is the purpose of antibody class switching?

<p>To change the antibody isotype produced by B cells (A)</p> Signup and view all the answers

Which cells are subject to Darwinian selection resulting in a 'better' B cell for specific antigen recognition and response?

<p>B cells that have undergone somatic hypermutation (D)</p> Signup and view all the answers

What is the process by which B cells produce antibodies with increased affinity for antigen during an immune response?

<p>Affinity maturation (D)</p> Signup and view all the answers

What is the enzyme responsible for introducing point mutations during somatic hypermutation?

<p>Activation induced cytidine deaminase (AID) (A)</p> Signup and view all the answers

What is the first targeted switch region in class switch recombination?

<p>Sµ switch region (A)</p> Signup and view all the answers

What determines the partner switch region in class switch recombination?

<p>The cytokines present (C)</p> Signup and view all the answers

What is the main goal of somatic hypermutation and affinity maturation?

<p>To fine tune B cells to recognize and respond to antigens (B)</p> Signup and view all the answers

What is the purpose of class switch recombination?

<p>To mount the most appropriate immunological response to antigen (C)</p> Signup and view all the answers

What is the mutation rate during somatic hypermutation compared to normal cell division?

<p>~1 base per 1000 (C)</p> Signup and view all the answers

What is the enzyme critical for both somatic hypermutation and class switch recombination?

<p>Activation induced cytidine deaminase (AID) (A)</p> Signup and view all the answers

What is the purpose of affinity maturation?

<p>To produce antibodies with increased affinity for antigen (B)</p> Signup and view all the answers

What is the primary goal of somatic hypermutation and affinity maturation?

<p>To optimize B cell recognition and response to antigens (C)</p> Signup and view all the answers

What is the role of follicular dendritic cells in affinity maturation?

<p>They present antigens to B cells (B)</p> Signup and view all the answers

What is the mutation rate during somatic hypermutation compared to normal cell division?

<p>1 base per 1,000 (C)</p> Signup and view all the answers

What is the purpose of class switch recombination?

<p>To allow B cells to perform different effector functions (A)</p> Signup and view all the answers

What determines the partner switch region in class switch recombination?

<p>The cytokines secreted by follicular T helper cells (A)</p> Signup and view all the answers

What happens to B cells that have undergone somatic hypermutation but bind antigens with lower affinity?

<p>They undergo apoptosis (D)</p> Signup and view all the answers

What is the role of activation-induced cytidine deaminase (AID) in class switch recombination?

<p>To catalyze the rearrangement of constant regions in B cell receptors (D)</p> Signup and view all the answers

What happens to B cells that do not recognize the antigen better after somatic hypermutation?

<p>They undergo apoptosis (D)</p> Signup and view all the answers

What is the relationship between somatic hypermutation and affinity maturation?

<p>Somatic hypermutation leads to affinity maturation (A)</p> Signup and view all the answers

What is the purpose of introducing genetic alterations in B cell receptors during somatic hypermutation?

<p>To increase the diversity of B cell receptors (C)</p> Signup and view all the answers

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