Questions and Answers
What is the predominant immunoglobulin involved in the body's initial immune response to an antigen?
What is the major serum immunoglobulin that accounts for 80%?
IgG
What is the predominant Ig found in body secretions?
IgA
IgE is present in trace amounts on the surface of most cells.
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IgD makes up ____% of serum immunoglobulins.
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Which immunoglobulin is responsible for allergic reactions?
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What is the typical structure of IgA?
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Study Notes
Immunoglobulin Classes Overview
- Immunoglobulin (Ig) classes play crucial roles in the immune system, each with unique characteristics and functions.
IgM
- Predominantly involved in the initial immune response to antigens.
- Capable of binding to up to 10 antigens simultaneously, even without prior exposure.
- Accounts for approximately 6% of total serum immunoglobulin.
- Structurally a pentamer, enhancing its binding capacity.
IgG
- Major component of serum immunoglobulins, constituting about 80%.
- Provides immunological defense for newborns; the only Ig class that can cross the placenta.
- Acts as the primary antibody during the secondary immune response, functioning as the body’s memory for specific antigens.
- Exists as a monomer, allowing for flexibility in immune responses.
IgA
- Predominantly found in various body secretions, including saliva, tears, human milk, vaginal fluid, and bronchial mucus.
- Serves as the first line of defense against local infections, particularly at mucous membrane surfaces.
- Makes up about 13% of serum immunoglobulins.
- Typically exists as a polymeric form, often in dimer configuration, promoting effective local immunity.
IgE
- Present in trace amounts, primarily on the surface of most cells.
- Plays a key role in allergic reactions and immediate hypersensitivity responses, such as hay fever, asthma, and hives.
- Exists as a monomer, affecting its interaction with allergens and immune cells.
IgD
- Its exact function remains less defined compared to other immunoglobulins.
- Primarily located on the surface of B lymphocytes, playing a role in antigen recognition and activation.
- Makes up about 1% of serum immunoglobulins.
- Exists as a monomer, facilitating its role in the immune system.
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Description
Test your knowledge of the different classes of immunoglobulins with these flashcards. Learn about the functions and characteristics of IgM, IgG, and other immunoglobulins vital for the immune response. This quiz is perfect for students of immunology or healthcare professionals seeking to refresh their understanding.
