Immunodeficiency Disorders Quiz

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Questions and Answers

Which component of the immune system is predominantly affected in primary immunodeficiency states (IDS) of adaptive immunity?

  • Macrophage link
  • NK-cell link
  • Complement system
  • B-cell link (correct)

Which type of immunodeficiency involves a decrease in the functional activity of the main components of the immune system?

  • Secondary immunodeficiency states (correct)
  • Combined T- and B-immunodeficiencies
  • Primary immunodeficiency states
  • Complement system deficiencies

What is the main cause of the formation of secondary immunodeficiencies?

  • Vaccination
  • Innate immune response
  • Genetic mutations
  • Preexisting diseases (correct)

What are primary deficiencies of the phagocytic link of innate immunity primarily associated with?

<p>Impaired macrophage function (A)</p> Signup and view all the answers

What are physiological (age-related) immunodeficiencies primarily attributed to?

<p>Thymus involution (A)</p> Signup and view all the answers

Which type of immunodeficiency involves a predominant lesion of the T-cell link in adaptive immunity?

<p>Combined T- and B-immunodeficiencies (D)</p> Signup and view all the answers

What is the main characteristic of immunodeficiency states (IDS)?

<p>Inability of the immune system to develop a normal immune response (C)</p> Signup and view all the answers

What are the main causes of the formation of secondary immunodeficiencies?

<p>Preexisting diseases, iatrogenic factors, adverse environmental factors, and lifestyle risk factors (B)</p> Signup and view all the answers

What is the role of physiological (age-related) immunodeficiencies?

<p>Contribute to a decline in immune function with age (C)</p> Signup and view all the answers

In primary immunodeficiency states, what is the predominant lesion of the B-cell link associated with?

<p>Impaired antibody production (A)</p> Signup and view all the answers

Flashcards

Adaptive IDS

Primary immunodeficiency states (IDS) that primarily affect the adaptive immune system's B-cell component.

Secondary IDS

Immunodeficiencies that arise due to underlying diseases, medications, or environmental factors.

Cause of Secondary IDS

Secondary Immunodeficiencies are caused by pre-existing diseases, medications, environmental factors, and lifestyle choices.

Phagocytic IDS

Primary immunodeficiency states that affect the innate immune system's phagocytic cells, specifically macrophages.

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Physiological IDS

Immunodeficiencies that naturally occur with aging due to thymus involution.

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Combined T- and B-cell IDS

Primary immunodeficiency states characterized by defects in both T-cell and B-cell components of the adaptive immune system.

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Characteristic of IDS

Immunodeficiency states (IDS) are characterized by the immune system's inability to mount a normal immune response.

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Causes of Secondary IDS

Secondary immunodeficiencies are caused by pre-existing diseases, medications (iatrogenic), environmental factors, and lifestyle risk factors.

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Role of Physiological IDS

Physiological immunodeficiencies contribute to the decline in immune function that naturally occurs with aging.

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B-cell Link Lesion in Primary IDS

The predominant lesion in primary immunodeficiency states affecting the B-cell link is impaired antibody production.

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Study Notes

Primary Immunodeficiency States (IDS)

  • Primary immunodeficiency states (IDS) of adaptive immunity predominantly affect the T-cell or B-cell links.

Types of Immunodeficiency

  • Combined immunodeficiency involves a decrease in the functional activity of the main components of the immune system.

Secondary Immunodeficiencies

  • The main cause of the formation of secondary immunodeficiencies is a decrease in the functional activity of the immune system due to various external factors.
  • The main causes of secondary immunodeficiencies include infections, cancers, immune disorders, and treatments that suppress the immune system.
  • Primary deficiencies of the phagocytic link of innate immunity are primarily associated with defects in the structure and function of phagocytic cells, such as neutrophils and macrophages.
  • Physiological (age-related) immunodeficiencies are primarily attributed to the decline of immune function with aging.
  • The role of physiological (age-related) immunodeficiencies is to impair the body's ability to respond to infections and diseases.
  • Immunodeficiency involving a predominant lesion of the T-cell link in adaptive immunity is known as T-cell immunodeficiency.

Characteristics of Immunodeficiency States

  • The main characteristic of immunodeficiency states (IDS) is the impaired ability of the immune system to respond to infections and diseases.
  • In primary immunodeficiency states, the predominant lesion of the B-cell link is associated with defects in antibody production and humoral immunity.

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