Immunopathology BMS CLASS
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Questions and Answers

Which type of immunity is the first line of defense against pathogens?

  • Adaptive immunity
  • Mucous membrane immunity
  • Innate immunity (correct)
  • Complement immunity

What is the main function of adaptive immunity?

  • Recognize and eliminate foreign microbes (correct)
  • Act as the first line of defense against pathogens
  • Provide susceptibility to disease
  • Maintain homeostasis in the body

Which component plays a role in disease and is part of the immune system?

  • Skin
  • Complement system (correct)
  • Mucous membranes
  • Innate immunity

What determines the efficacy of the immune system?

<p>Ability to distinguish between foreign and self-components (A)</p> Signup and view all the answers

What is the absence of immunity called?

<p>Susceptibility (D)</p> Signup and view all the answers

Which type of immunity provides a rapid response to antigens but is not specific?

<p>Innate (Natural) Immunity (B)</p> Signup and view all the answers

What is the distinguishing mechanism between the 5 different types of antibodies (Ab)?

<p>Constant regions (D)</p> Signup and view all the answers

Which cells are part of the Innate Immune System and are known for their phagocytic activity?

<p>Monocytes (B)</p> Signup and view all the answers

What percentage of antibodies present in the body does Immunoglobulin A (IgA) account for?

<p>10-15% (D)</p> Signup and view all the answers

Which cells of the Adaptive Immune System produce antibodies?

<p>B-Lymphocytes (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction is T-cell mediated?

<p>Type IV (C)</p> Signup and view all the answers

What type of immunity is acquired following exposure to a microbe?

<p>Naturally acquired active immunity (B)</p> Signup and view all the answers

Which type of immunity involves the transfer of IgG across the placenta and IgA from breast-feeding?

<p>Naturally acquired passive immunity (D)</p> Signup and view all the answers

In which hypersensitivity reaction does IgE bind to Mast Cells, leading to histamine release?

<p>Type I (A)</p> Signup and view all the answers

What type of immunity is induced during vaccination and involves immunogenic but not pathogenic antigens?

<p>Artificially acquired active immunity (D)</p> Signup and view all the answers

Which antibody is the smallest and most common?

<p>Immunoglobulin G (IgG) (A)</p> Signup and view all the answers

Which antibody induces other immune system cells to destroy foreign substances?

<p>Immunoglobulin M (IgM) (C)</p> Signup and view all the answers

Which antibody is located on mast cells and basophils and is involved in allergic reactions?

<p>Immunoglobulin E (IgE) (D)</p> Signup and view all the answers

Which antibody provides passive immunity to the fetus by crossing the placenta?

<p>Immunoglobulin G (IgG) (A)</p> Signup and view all the answers

Which antibody is present in blood and lymph and is the first antibody to respond in infections?

<p>Immunoglobulin M (IgM) (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction is characterized by a delayed cellular response mediated by T-cells?

<p>Type IV (A)</p> Signup and view all the answers

In transplant rejection, acute rejection occurs due to preformed anti-donor antibodies present in the recipient's circulation. Which type of hypersensitivity reaction does this represent?

<p>Type II (A)</p> Signup and view all the answers

What is the main effect of T-cells becoming sensitized and activated in response to antigen-presenting cells (APC) phagocytosing the antigen?

<p>Release of cytokines and chemokines causing tissue damage (B)</p> Signup and view all the answers

What is the main role of complexes formed by injected Ag and antibodies (Ag-Ab) in the context of immunological reactions?

<p>Activate the complement cascade (A)</p> Signup and view all the answers

Which condition is characterized by widespread acute arteritis, arteriolitis, thrombosis of vessels, and necrosis in the context of transplant rejection?

<p>Acute transplant rejection (D)</p> Signup and view all the answers

Which primary immunodeficiency disorder is 10 times more common in women and most commonly presents in African Americans?

<p>Selective IgA deficiency (D)</p> Signup and view all the answers

What is the most appropriate initial treatment for systemic lupus erythematosus according to presentation?

<p>Plaquenil (D)</p> Signup and view all the answers

Which autoimmune disorder presents with severe dryness (Sicca) due to inflammation and damage to lacrimal and salivary glands?

<p>Sjogren’s Syndrome (B)</p> Signup and view all the answers

Which immunodeficiency disorder is characterized by a breakdown in tolerance in genetically susceptible individuals, leading to the activation of autoimmunity?

<p>Selective IgA deficiency (C)</p> Signup and view all the answers

What is the most common manifestation of systemic lupus erythematosus that presents as a malar or butterfly rash?

<p>Mucocutaneous manifestations (D)</p> Signup and view all the answers

Which test is used to screen for autoimmune related diseases?

<p>Human Leukocyte Antigen (HLA-B27) (A)</p> Signup and view all the answers

What CD4 cell count defines Severe/Advanced HIV/AIDS?

<p>Less than 200 cells/microL (A)</p> Signup and view all the answers

What is the primary infection period for HIV/AIDS?

<p>2-4 weeks (D)</p> Signup and view all the answers

Which disease is associated with deficiency of IgA?

<p>Common variable immunodeficiency (CVID) (A)</p> Signup and view all the answers

Which test is used to identify HIV infection within 1 hour?

<p>Rapid Tests (D)</p> Signup and view all the answers

Which antibody test is used for screening autoimmune diseases like systemic lupus erythematosus?

<p>Antinuclear Antibody (ANA) Test (B)</p> Signup and view all the answers

What is the primary symptom of the chronic infection phase of HIV/AIDS?

<p>Fatigue (C)</p> Signup and view all the answers

Which disease is associated with Wiskott-Aldrich Syndrome?

<p>DiGeorge Syndrome (D)</p> Signup and view all the answers

Which virus causes a late-stage HIV infection?

<p>HIV (C)</p> Signup and view all the answers

What type of antibodies are tested in the Anti-nuclear cytoplasmic antibodies (ANCA) Test?

<p>Antibodies against cytoplasmic antigens (A)</p> Signup and view all the answers

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