Immunology Quiz (BMS Learning Outcomes)
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Questions and Answers

What is the primary function of macrophages in the immune system?

  • Secretion of antibodies
  • Production of platelets
  • Degranulation of enzymes
  • Phagocytosis and antigen presentation (correct)
  • What is the primary role of mast cells in the immune system?

  • Release of inflammatory mediators (correct)
  • Antigen presentation to B cells
  • Activation of T cells
  • Production of antibodies
  • Which organ is primarily responsible for the maturation of T lymphocytes?

  • Spleen
  • Thymus (correct)
  • Lymph nodes
  • Bone marrow
  • What type of cell is most commonly associated with allergic reactions?

    <p>Basophils (A)</p> Signup and view all the answers

    Which type of cell acts as the main bridge between the innate and adaptive immune systems?

    <p>Dendritic cells (D)</p> Signup and view all the answers

    Which of the following sets of cells is primarily responsible for the adaptive immune response?

    <p>B cells and T cells (C)</p> Signup and view all the answers

    Which immune cells are primarily responsible for targeting bacteria and fungi?

    <p>Neutrophils (D)</p> Signup and view all the answers

    What is a key characteristic that differentiates adaptive immunity from innate immunity?

    <p>It can remember pathogens (C)</p> Signup and view all the answers

    Where are B lymphocytes matured?

    <p>Bone marrow (B)</p> Signup and view all the answers

    Which function is NOT associated with neutrophils?

    <p>Antigen presentation (C)</p> Signup and view all the answers

    In which location do T cells mature?

    <p>Thymus (C)</p> Signup and view all the answers

    What role do cytokines play in the immune response?

    <p>Recruit other immune cells (D)</p> Signup and view all the answers

    What type of immune response is primarily mediated by cytotoxic T cells?

    <p>Cell-mediated immunity (C)</p> Signup and view all the answers

    Which characteristic is true for innate immunity?

    <p>Responds immediately to pathogens (D)</p> Signup and view all the answers

    Which organ acts as a filter for pathogens entering the bloodstream?

    <p>Spleen (B)</p> Signup and view all the answers

    Which cells derive from myeloblasts in the innate immune system?

    <p>Basophils and Eosinophils (B)</p> Signup and view all the answers

    What type of cell is primarily responsible for antibody production in the adaptive immune response?

    <p>Plasma cells (B)</p> Signup and view all the answers

    Which pathway of the complement system is activated by bacterial cell wall structures?

    <p>Alternative pathway (C)</p> Signup and view all the answers

    What is the main target of eosinophils in the immune response?

    <p>Parasites (D)</p> Signup and view all the answers

    What distinguishes T helper cells (CD4+) from cytotoxic T cells (CD8+)?

    <p>CD4+ cells primarily mediate immune responses (B)</p> Signup and view all the answers

    Flashcards

    What is the role of bone marrow in the immune system?

    Bone marrow is where all immune cells are formed. B lymphocytes mature here, while T lymphocytes travel to the thymus.

    What is the function of the thymus?

    The thymus is the site where T cells mature and develop their immune functions.

    What is the function of lymph nodes in the immune system?

    Lymph nodes are small, bean-shaped organs that filter lymph fluid and house immune cells like T and B lymphocytes. They play a crucial role in recognizing and fighting infections.

    What is the function of the spleen in the immune system?

    The spleen is a large organ that filters blood, stores platelets and white blood cells, and destroys old or damaged red blood cells. It's also involved in recognizing and responding to pathogens in the blood.

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    What is the role of macrophages?

    Macrophages are large phagocytic cells that engulf and destroy pathogens, old cells, and debris. They also present antigens to T cells, which helps activate the adaptive immune response.

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    What is the role of neutrophils?

    Neutrophils are a type of white blood cell that are the first responders to infection. They use phagocytosis to engulf bacteria and fungi, and they release substances that kill these invaders.

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    What is the role of eosinophils?

    Eosinophils are a type of white blood cell that primarily target parasites. They release substances that damage and kill these larger invaders.

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    What is the role of basophils?

    Basophils are white blood cells involved in allergic reactions. They release histamine, which causes inflammation, and other substances that contribute to the allergic response.

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    What is the innate immune system?

    The innate immune system is the body's first line of defense against pathogens. It is a general, nonspecific response that does not target specific invaders.

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    What is the adaptive immune system?

    The adaptive immune system is a highly specific immune response that targets particular pathogens. It involves the development of memory cells that allow for a faster and more effective response to reinfection.

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    Mast Cells

    WBCs with granules rich in histamine and heparin, derived from bone marrow myeloid stem cells, mature in tissues, and are crucial for innate immunity, particularly against parasitic infections and allergic reactions.

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    Dendritic Cells

    Mononuclear leukocytes that link innate and adaptive immunity, acting as messengers between the two systems. They are the most potent antigen-presenting cells, activating T cells and driving B cell differentiation to initiate adaptive immune responses.

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    B Cells

    Mononuclear leukocytes responsible for humoral (antibody-mediated) immunity. They mature in the bone marrow and differentiate into plasma cells (antibody-secreting) and memory cells, providing long-term immunity.

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    T Cells

    Mononuclear leukocytes that mature in the thymus and are crucial for cell-mediated immunity. They differentiate into T helper cells (CD4+) and cytotoxic T cells (CD8+), playing a vital role in controlling intracellular infections, eliminating virus-infected and tumor cells, and assisting B cell responses.

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    Innate Immunity

    The body's immediate, non-specific defense against pathogens, effective within hours of exposure. It relies on physical barriers, physiological mechanisms, and innate immune cells like macrophages and NK cells.

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    Adaptive Immunity

    The specific, long-lasting immune response that develops after exposure to an antigen. It involves T cells, B cells, and antibodies, providing long-term protection against specific pathogens.

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    Inflammation

    The body's response to tissue damage or microbial invasion, characterized by redness, swelling, heat, and pain. It aims to isolate and destroy pathogens, remove debris, and promote healing.

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    Complement System

    A group of proteins in blood that act as a complex enzyme cascade, playing a critical role in innate immunity by complementing other immune components.

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    Cytokines

    Glycoproteins that act as messengers within the immune system, regulating immune responses by either stimulating or suppressing immune cell activity. Examples include cytokines secreted by helper T cells and macrophages.

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    Natural Killer (NK) Cells

    Specialized cells that kill infected cells or tumors without prior sensitization, representing part of innate immune defense.

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    Study Notes

    Immune System Organs and Tissues

    • Primary Lymphoid Organs:

      • Bone Marrow: Site of all immune cell formation, including B cell maturation. T cells travel to the thymus for maturation.
      • Thymus: Location of T cell maturation.
    • Secondary Lymphoid Organs:

      • Lymph Nodes: Houses T and B cells.
      • Tonsils: Part of the lymphatic system, located in the throat.
      • Mucous Membranes: Found in various locations (e.g., bladder, genitals, bowel)
      • Skin: A physical barrier to pathogens.
      • Spleen: Filters blood, stores platelets and WBCs, and contains phagocytes that destroy pathogens. Macrophages break down pathogens.

    Immune System Cells: Origins and Functions

    • Macrophages:

      • Type: Mononuclear leukocyte, Phagocyte
      • Origin: Monocytes that differentiate into macrophages once exiting the bloodstream
      • Differentiation: Kupffer cells (liver), histiocytes (connective tissue)
      • Functions: Phagocytosis, antigen presentation to T cells, cytokine release to trigger inflammation, clearing old/damaged cells
      • Targets: Old, damaged, and dead cells, pathogens
    • Neutrophils:

      • Type: Granulocyte, Phagocyte
      • Origin: Myeloblast
      • Differentiation: Most common WBC (polymorphonuclear)
      • Functions: Phagocytosis, degranulation, release of superoxides to kill multiple bacteria
      • Targets: Bacteria, fungi
    • Eosinophils:

      • Type: Granulocyte
      • Origin: Myeloblast
      • Functions: Degranulation, histamine and enzyme release
      • Targets: Parasites, allergic reactions
    • Basophils:

      • Type: Granulocyte
      • Origin: Myeloblast
      • Functions: Degranulation, histamine and enzyme release, secrete anticoagulants (heparin) to facilitate WBC movement, secrete antibodies against hypersensitivity reactions, histamine dilates blood vessels to bring more immune cells to the area
      • Targets: Allergic reactions, promoters of mobility of other WBCs, hypersensitivity reactions
    • Mast Cells:

      • Type: Granulocyte (high histamine, heparin)
      • Origin: Bone marrow myeloid stem cell
      • Differentiation: Mature in tissues after release from bone marrow
      • Functions: Release inflammatory mediators (cytokines) after activation by antigens, host defense to parasitic infection
      • Targets: Allergic reactions, parasitic infections
    • Dendritic Cells:

      • Type: Mononuclear leukocyte
      • Origin: Monocytes (nodes, spleen)
      • Function: Antigen-presenting cells, link innate and adaptive immunity, activate T cells, stimulate B cell production
      • Targets: Capture and process antigens, regulating immune response
    • Lymphocytes (B cells):

      • Type: Mononuclear leukocyte
      • Origin: Lymphoblast, mature in bone marrow
      • Differentiation: Plasma cells (antibody-producing), memory cells
      • Function: Antibody production, memory for secondary immune response
      • Targets: Foreign antigens
    • Lymphocytes (T cells):

      • Type: Mononuclear leukocyte
      • Origin: Lymphoblast, mature in thymus
      • Differentiation: Helper T cells (Th), cytotoxic T cells
      • Function: Helper T cells mediate immune response, cytotoxic T cells destroy infected/cancer cells; essential for B cell responses to antigen
      • Targets: Helper T cells (intracellular bacteria), Cytotoxic T cells (virus-infected and tumor cells) Natural Killer cells (virus infected and tumor cells)

    Innate vs. Adaptive Immunity

    Feature Innate Immunity Adaptive Immunity
    Specificity Non-specific Specific
    Time Immediate (hours) Days/weeks (lag)
    Antigen-dependent? No Yes
    Memory No Yes

    Innate Immunity Mechanisms

    • Defense Barriers: Anatomical (skin, mucous membrane) and physiological (body temperature, low pH)
    • Endocytic/Phagocytic Processes: Ingesting and destroying pathogens
    • Inflammatory Response: Isolating, destroying, and inactivating pathogens; recruiting immune cells
    • Humoral Factors:
      • Complement System: Enzyme group in blood (components 1-9), activated by immune complexes or bacterial structures.
      • Cytokines: Proteins that modulate (increase or decrease) immune response.

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    Description

    Test your knowledge on the organs and tissues of the immune system. This quiz covers the primary and secondary lymphoid organs, as well as the origins and functions of various immune cells like macrophages. Dive into the complexities of how our body fights off pathogens!

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