NSAIDS DENTAL
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Questions and Answers

Which of the following is the chief clinical use of NSAIDS?

  • Treatment of fever
  • Treatment of mediator induction
  • Treatment of musculoskeletal disorders (correct)
  • Treatment of monocyte/macrophage activation
  • Which of the following is NOT an adverse reaction of Aspirin?

  • Gastric upset
  • Upper GI bleeding
  • Decreased serum uric acid levels (correct)
  • Decreased hearing
  • Which mediator is responsible for inducing fever?

  • IL-6 (correct)
  • IL-1
  • NSAIDS
  • TNFα
  • What is the clinical use of Aspirin?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is an adverse reaction of Aspirin?

    <p>All of the above</p> Signup and view all the answers

    What is the role of IL-1 in the body?

    <p>All of the above</p> Signup and view all the answers

    Which enzyme is responsible for metabolizing Aspirin?

    <p>Cytochrome p450</p> Signup and view all the answers

    Which body fluid is Acetaminophen uniformly distributed to?

    <p>Most body fluids</p> Signup and view all the answers

    What is the role of TNFα in the body?

    <p>All of the above</p> Signup and view all the answers

    Which enzyme is responsible for metabolizing Acetaminophen?

    <p>Hepatic microsomal enzymes</p> Signup and view all the answers

    Where is Aspirin distributed in the body?

    <p>Synovial fluid</p> Signup and view all the answers

    Which of the following is a common adverse reaction of Aspirin?

    <p>Gastrointestinal bleeding</p> Signup and view all the answers

    Which of the following is an adverse reaction of Acetaminophen?

    <p>Skin rash</p> Signup and view all the answers

    Which of the following adverse reactions is most common with Acetaminophen overdose?

    <p>Hepatotoxicity</p> Signup and view all the answers

    Which of the following is NOT an adverse reaction of Ibuprofen?

    <p>Skin rash</p> Signup and view all the answers

    Which of the following is NOT A suitable use of Acetaminophen?

    <p>Patients with compromised liver function</p> Signup and view all the answers

    Which enzyme is necessary for cytoprotection in the GI tract?

    <p>COX-1</p> Signup and view all the answers

    What is the half life of Naproxen?

    <p>14 hours</p> Signup and view all the answers

    Which adverse reaction is commonly associated with Naproxen?

    <p>All of the above</p> Signup and view all the answers

    Which enzyme is believed to be the main producer of prostanoid mediators of inflammation?

    <p>COX-2</p> Signup and view all the answers

    What is the primary pharmacodynamic effect of Acetaminophen?

    <p>Anti-pyretic activity</p> Signup and view all the answers

    Which enzyme is constitutively active and expressed in most tissues?

    <p>COX-1</p> Signup and view all the answers

    Which enzyme is induced in inflammatory cells and plays a crucial role in the pain response?

    <p>COX-2</p> Signup and view all the answers

    Which adverse reaction is commonly associated with Celecoxib?

    <p>All of the above</p> Signup and view all the answers

    What is the half-life of Celecoxib?

    <p>11 hours</p> Signup and view all the answers

    Which body system is most affected by the adverse reaction of Celecoxib?

    <p>Cardiovascular</p> Signup and view all the answers

    Which enzyme is inhibited by Celecoxib?

    <p>COX-2</p> Signup and view all the answers

    Which enzyme does Methotrexate inhibit?

    <p>Dihydrofolate reductase</p> Signup and view all the answers

    What is the lag phase before observing the clinical effect of Methotrexate in rheumatoid arthritis?

    <p>3-6 weeks</p> Signup and view all the answers

    What effect does Methotrexate have on adenosine release by neutrophils?

    <p>Increases adenosine release</p> Signup and view all the answers

    What is the effect of Celecoxib on platelet aggregation at usual doses?

    <p>Has no effect on platelet aggregation</p> Signup and view all the answers

    How does the selectivity of Celecoxib for COX-2 compare to COX-1?

    <p>Celecoxib is more selective for COX-2 than COX-1</p> Signup and view all the answers

    Which drug is a chimeric monoclonal antibody that binds with high affinity and specificity to human TNFα?

    <p>Infliximab</p> Signup and view all the answers

    What is the primary indication for Infliximab therapy?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What is the prevalence of anti-Infliximab antibodies formation in patients receiving Infliximab?

    <p>Up to 50%</p> Signup and view all the answers

    Which therapy greatly reduces the prevalence of anti-drug antibodies formation in patients receiving Infliximab?

    <p>Concurrent therapy with Methotrexate</p> Signup and view all the answers

    Which adverse reaction is NOT associated with Infliximab?

    <p>All of the above</p> Signup and view all the answers

    Which drug, in combination with methotrexate, is indicated for reducing signs and symptoms of moderate to severe active rheumatoid arthritis in patients who have had an inadequate response to methotrexate?

    <p>Infliximab</p> Signup and view all the answers

    Which medication binds to two TNFα molecules and inactivates them before they can trigger inflammation?

    <p>Etanercept</p> Signup and view all the answers

    Which medication is a fully human IgG anti-TNF monoclonal antibody?

    <p>Adalimumab</p> Signup and view all the answers

    Which medication has a serum peak 72 hours after subcutaneous injection?

    <p>Etanercept</p> Signup and view all the answers

    Which medication is known to cause rare CNS reactions, including seizures?

    <p>Etanercept</p> Signup and view all the answers

    Which medication has a half-life of up to 20 days?

    <p>Adalimumab</p> Signup and view all the answers

    Which medication has a rare adverse effect of vasculitis?

    <p>Adalimumab</p> Signup and view all the answers

    Which medication binds two TNFα molecules and inactivates them before triggering inflammation?

    <p>Etanercept</p> Signup and view all the answers

    Which medication has an anti-antibody response that is inhibited by methotrexate?

    <p>Adalimumab</p> Signup and view all the answers

    Which medication binds to TNF and inactivates it before it can trigger inflammation?

    <p>Etanercept</p> Signup and view all the answers

    Which adverse effect is associated with Adalimumab?

    <p>All of the above</p> Signup and view all the answers

    Which medication is a recombinant fusion protein consisting of two soluble TNF p75 receptor moieties linked to the Fc portion of human IgG1?

    <p>Etanercept</p> Signup and view all the answers

    Study Notes

    NSAIDs

    • NSAIDs are primarily used to treat pain, reduce inflammation, and lower fever
    • Aspirin is used to relieve mild to moderate pain, reduce inflammation, and lower fever
    • Acetaminophen is used to relieve pain and reduce fever, but not to reduce inflammation
    • NSAIDs work by inhibiting COX-1 and COX-2 enzymes, which produce prostaglandins that cause pain and inflammation

    Adverse Reactions of Aspirin

    • Common adverse reactions of Aspirin include gastrointestinal upset, bleeding, and ringing in the ears
    • Aspirin can cause gastrointestinal bleeding and ulcers due to inhibition of COX-1
    • Aspirin can also cause hypersensitivity reactions and Reye's syndrome in children

    Metabolism of NSAIDs

    • Aspirin is metabolized by esterase in the liver
    • Acetaminophen is metabolized by CYP2E1 and glucuronidation in the liver
    • Naproxen is metabolized by CYP2C9 and glucuronidation in the liver

    Pharmacology of Acetaminophen

    • Acetaminophen is uniformly distributed in the body fluids
    • Acetaminophen has a primary pharmacodynamic effect of blocking the production of prostaglandins in the brain, which reduces fever
    • The primary adverse effect of Acetaminophen overdose is liver damage

    COX Enzymes

    • COX-1 is constitutively active and expressed in most tissues
    • COX-2 is induced in inflammatory cells and plays a crucial role in the pain response
    • COX-2 is inhibited by Celecoxib, a selective COX-2 inhibitor

    TNFα Inhibitors

    • TNFα is a mediator of inflammation and fever
    • Infliximab is a chimeric monoclonal antibody that binds to human TNFα
    • Infliximab is indicated for moderate to severe active rheumatoid arthritis
    • Adalimumab is a fully human IgG anti-TNF monoclonal antibody
    • Etanercept is a recombinant fusion protein consisting of two soluble TNF p75 receptor moieties linked to the Fc portion of human IgG1

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    Description

    This quiz will test your knowledge on the roles and functions of IL-1, TNFα, IL-6, NSAIDs, and Aspirin in the immune system and clinical applications. Test your understanding of lymphocyte activation, mediator induction, monocyte/macrophage activation, and more.

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