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Questions and Answers
Which of the following is NOT a physical barrier to infection?
Which of the following is NOT a physical barrier to infection?
What is the primary role of the thymus in the immune system?
What is the primary role of the thymus in the immune system?
Which cell type is responsible for producing antibodies?
Which cell type is responsible for producing antibodies?
What is the function of lymph nodes in the immune system?
What is the function of lymph nodes in the immune system?
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What is the role of the bone marrow in the immune system?
What is the role of the bone marrow in the immune system?
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Which of the following describes the spleen's function?
Which of the following describes the spleen's function?
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What is the function of a T cell receptor (TCR)?
What is the function of a T cell receptor (TCR)?
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What is the significance of removing self-reactive T and B cells during their development?
What is the significance of removing self-reactive T and B cells during their development?
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Which process describes how a cell self-destructs?
Which process describes how a cell self-destructs?
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What is the primary role of B cells in the immune response?
What is the primary role of B cells in the immune response?
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Which of the following molecules is NOT typically recognized by the immune system as an antigen?
Which of the following molecules is NOT typically recognized by the immune system as an antigen?
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Which type of cell is responsible for directly killing infected cells by triggering apoptosis?
Which type of cell is responsible for directly killing infected cells by triggering apoptosis?
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Which immune cells are primarily responsible for inducing apoptosis in virus-infected cells?
Which immune cells are primarily responsible for inducing apoptosis in virus-infected cells?
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What is the function of histamine in the inflammatory response?
What is the function of histamine in the inflammatory response?
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What is the role of MHC proteins in the adaptive immune response?
What is the role of MHC proteins in the adaptive immune response?
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Which immune cell acts as an antigen-presenting cell (APC) and is crucial for activating T cells?
Which immune cell acts as an antigen-presenting cell (APC) and is crucial for activating T cells?
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Which type of immune response is characterized by its specificity and the development of memory?
Which type of immune response is characterized by its specificity and the development of memory?
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Where do immune cells, and red blood cells develop?
Where do immune cells, and red blood cells develop?
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What is the primary function of cytotoxic T cells?
What is the primary function of cytotoxic T cells?
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Which of the following best describes the role of cytokines in the immune system?
Which of the following best describes the role of cytokines in the immune system?
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What is the role of plasma cells in the humoral immune response?
What is the role of plasma cells in the humoral immune response?
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Which of the following initiates an adaptive immune response?
Which of the following initiates an adaptive immune response?
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Memory cells provide which critical benefit to the immune system?
Memory cells provide which critical benefit to the immune system?
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What is the primary function of the major histocompatibility complex (MHC) protein?
What is the primary function of the major histocompatibility complex (MHC) protein?
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Which of the following best distinguishes the innate from the adaptive immune response?
Which of the following best distinguishes the innate from the adaptive immune response?
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What is the primary difference between a primary and secondary immune response?
What is the primary difference between a primary and secondary immune response?
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What is the purpose of using a live-attenuated vaccine?
What is the purpose of using a live-attenuated vaccine?
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What fluid circulates through the body in lymphatic vessels?
What fluid circulates through the body in lymphatic vessels?
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An autoimmune disease occurs when the immune system mistakenly attacks...
An autoimmune disease occurs when the immune system mistakenly attacks...
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Which type of vaccine uses genetic material to instruct cells to produce a viral protein?
Which type of vaccine uses genetic material to instruct cells to produce a viral protein?
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What is the role of complement proteins in the immune response?
What is the role of complement proteins in the immune response?
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If a person receives a vaccine, how does their immune system respond when they later encounter the same pathogen?
If a person receives a vaccine, how does their immune system respond when they later encounter the same pathogen?
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What is the primary function of helper T cells?
What is the primary function of helper T cells?
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What is the primary function of mucous membranes?
What is the primary function of mucous membranes?
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Which type of cell is responsible for releasing histamine?
Which type of cell is responsible for releasing histamine?
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What is the process by which phagocytes engulf and destroy pathogens?
What is the process by which phagocytes engulf and destroy pathogens?
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What is the key characteristic of a secondary immune response compared to a primary immune response?
What is the key characteristic of a secondary immune response compared to a primary immune response?
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Which of the following is an example of a pathogen?
Which of the following is an example of a pathogen?
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What role do natural killer (NK) cells play in the immune system?
What role do natural killer (NK) cells play in the immune system?
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What is the function of plasma cells?
What is the function of plasma cells?
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What is the definition of a self-antigen?
What is the definition of a self-antigen?
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Which cell type is the first responder for the innate immune system?
Which cell type is the first responder for the innate immune system?
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What is the role of T cell receptors (TCR)?
What is the role of T cell receptors (TCR)?
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What is the function of memory cells in the adaptive immune system?
What is the function of memory cells in the adaptive immune system?
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What function do PAMPs serve in immunity?
What function do PAMPs serve in immunity?
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Which of the following best describes the purpose of a vaccine?
Which of the following best describes the purpose of a vaccine?
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Which of these is a phagocytic cell?
Which of these is a phagocytic cell?
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Where do lymphoid progenitor cells differentiate to?
Where do lymphoid progenitor cells differentiate to?
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Flashcards
The Skin's Role in Immunity
The Skin's Role in Immunity
The outer layer of the skin, composed of dead cells, acts as a physical barrier to prevent pathogens from entering the body.
Mucus's Defensive Role
Mucus's Defensive Role
Sticky mucus traps invading pathogens in the respiratory and digestive systems, preventing them from reaching deeper tissues.
Saliva and Sweat's Immune Function
Saliva and Sweat's Immune Function
Saliva and sweat contain enzymes and antibodies that can directly destroy pathogens.
Stomach Acid: A Microbial Killer
Stomach Acid: A Microbial Killer
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Where are Immune Cells Created?
Where are Immune Cells Created?
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Lymphoid Progenitors: Building the Immune Response
Lymphoid Progenitors: Building the Immune Response
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The Thymus's Role in Immunity
The Thymus's Role in Immunity
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Lymph Nodes: Filtering and Fighting Pathogens
Lymph Nodes: Filtering and Fighting Pathogens
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What do NK cells do?
What do NK cells do?
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What do dendritic cells do?
What do dendritic cells do?
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What is Adaptive Immunity?
What is Adaptive Immunity?
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What are T cells and how do they work?
What are T cells and how do they work?
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What do activated T cells do?
What do activated T cells do?
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What are B cells and how are they activated?
What are B cells and how are they activated?
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What is the function of antibodies?
What is the function of antibodies?
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What are memory cells?
What are memory cells?
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What is the purpose of a vaccine?
What is the purpose of a vaccine?
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How do mRNA vaccines work?
How do mRNA vaccines work?
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Vaccine
Vaccine
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Toxins
Toxins
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Tonsils
Tonsils
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Thymus
Thymus
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T cell receptor (TCR)
T cell receptor (TCR)
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T cell
T cell
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Stem cell
Stem cell
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Spleen
Spleen
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Skin
Skin
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Self-antigen
Self-antigen
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Secondary immune response
Secondary immune response
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Receptors
Receptors
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Progenitor cells
Progenitor cells
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Antigen
Antigen
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Antigen-MHC complex
Antigen-MHC complex
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Antigen-presenting cell (APC)
Antigen-presenting cell (APC)
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Apoptosis
Apoptosis
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Autoimmune disease
Autoimmune disease
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Basophil
Basophil
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Bone marrow
Bone marrow
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Cell-mediated immune response
Cell-mediated immune response
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Complement proteins
Complement proteins
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Cytokines
Cytokines
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Cytotoxic T cell
Cytotoxic T cell
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Dendritic cell
Dendritic cell
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Digestive system
Digestive system
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Study Notes
Immune System Anatomy
-
Barriers to Infection:
- Skin: Forms a physical barrier; outer layer composed of dead cells.
- Mucus: Traps pathogens and protects mucous membranes (respiratory & digestive).
- Saliva & Sweat: Contain antibodies and enzymes to destroy pathogens.
- Stomach Acid: Kills many pathogens ingested.
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Bone Marrow:
- Spongy tissue in bones; site of blood stem cell production.
- Creates red blood cells and immune cells.
- Stem cells differentiate into lymphoid (T, B, NK cells) and myeloid (red blood cells, phagocytes).
- B cells mature in the bone marrow.
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Thymus:
- T cells develop here, migrating from bone marrow.
- T cells produce T cell receptors (TCRs) that bind pathogen antigens.
- T cells that recognize self-antigens are destroyed.
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Lymph Nodes:
- Scattered throughout the body; connected by lymphatic vessels.
- Lymph (tissue fluid) travels through lymphatic vessels to lymph nodes.
- Immune cells (B cells, T cells, phagocytes) attack pathogens here.
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Spleen:
- Removes old/damaged blood cells using phagocytes (dendritic cells, macrophages).
- Contains B and T cells to fight pathogens.
- Functions can be taken over by other lymphoid organs if damaged.
Immune System Activation & Response
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Activation: A process where a cell changes function in response to a stimulus.
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Adaptive Immune Cell: Include B cells and T cells. Involved in the adaptive immune response.
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Adaptive Immune Response:
- Provides long-lasting pathogen-specific protection.
- Response takes time to develop.
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Antibody:
- A protein binding a specific antigen.
- Produced by plasma cells.
- Helps neutralize pathogens.
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Antigen: Small biological material (protein, carbohydrate, lipid, nucleic acid) recognizable by the immune system.
- Triggers an immune response if from a pathogen or abnormal cell.
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Antigen-MHC Complex:
- Antigen bound to MHC protein on the cell surface.
- T cells need to bind to specific antigen-MHC complex for activation.
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Antigen-Presenting Cell (APC):
- Cell displaying an antigen bound to an MHC protein on its surface.
- Dendritic cells are common APCs.
- Interact with T cells to trigger an immune response
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Apoptosis: Cell self-destruction, essential for removing unwanted or abnormal cells.
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Autoimmune Disease: Immune system attacks healthy body cells.
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Basophil: Innate immune cell; involved in inflammation.
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B Cell: Adaptive immune cell targeting and destroying pathogens; differentiate into plasma cells upon T cell activation.
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B Cell Receptor (BCR): Protein on B cells binding specific antigens; key in B cell activation.
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Cell-Mediated Immune Response: Adaptive immune response targeting infected cells via cytotoxic T cells.
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Complement Proteins: Blood proteins assisting pathogen destruction.
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Cytokines: Signaling proteins between cells. Some alert or activate immune cells.
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Cytotoxic T Cell: A type of T cell killing infected cells via apoptosis.
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Dendritic Cell: Phagocyte that displays pathogen antigens to activate other immune cells.
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Differentiation: Change from one cell type to another, often more specialized, triggered by cytokines and hormones.
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Eosinophil: Innate immune cell; eliminates large pathogens (parasites) through chemical signals and damage.
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Engulfing: Phagocytes engulfing particles, forming a vesicle.
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Helper T Cell: T cell activating other immune cells (B cells and cytotoxic T cells).
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Histamine: Released by mast cells; triggers inflammation by making blood vessels leaky.
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Humoral Immune Response: Adaptive response involving antibodies, activating B cells.
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Immune Response: The immune system's process fighting pathogens.
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Immunocompromised: Weakened immune system efficiency.
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Inflammation: Innate response fighting pathogens and repairing tissue damage.
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Innate Immune Cell: Include phagocytes (macrophages, neutrophils, dendritic cells), mast cells, and NK cells.
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Innate Immune Response: Immediate, broad-spectrum protection—recognizes generalized pathogen components, not specific ones.
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Lymph: Fluid similar to blood (no red blood cells), containing immune cells.
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Lymphatic Vessels: Carry lymph throughout the body.
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Lymphocyte: Immune cell type (T cells, B cells, NK cells).
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Lymphoid Organs: Produce and contain immune cells (bone marrow, thymus, lymph nodes, spleen, tonsils).
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Macrophage: Phagocyte; engulfing and destroying pathogens and abnormal cells; releasing chemical signals (cytokines).
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Major Histocompatibility Complex (MHC) protein: Binds to antigens and displays them; critical for T cell activation.
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Mast Cell: Innate immune cell essential for inflammation, releasing chemical signals.
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Memory Cells: Long-lived B and T cells; quick immune response to subsequent infections.
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Microbe: Microscopic organism; some helpful, some pathogenic.
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Microbiome: Community of microbes living in/on the body; usually non-pathogenic.
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Monocyte: Innate cell differentiating into macrophages.
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Mucus Membrane: Thin tissue with mucus-producing cells; lining several systems (e.g., digestive, respiratory).
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Mucus: Sticky substance; protecting tissues and containing antimicrobial components.
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Natural Killer (NK) Cell: Innate immune cell killing infected/abnormal cells.
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Neutralization: Antibodies blocking pathogen interaction with body cells.
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Neutrophil: Innate immune cell; responding first to pathogens(bacteria and fungi).
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Pathogen: Disease-causing microbe.
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Phagocyte: Engulfing and destroying pathogens; includes neutrophils, monocytes, macrophages, dendritic cells.
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Phagocytosis: The process of engulfing and destroying pathogens and abnormal cells.
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Plasma Cell: Adaptive immune cell producing antibodies.
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Primary Immune Response: Initial immune system response to a pathogen.
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Progenitor Cells: Develop from stem cells; differentiating into other cell types.
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Receptor: Cell membrane proteins binding specific molecules for cell signaling.
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Secondary Immune Response: Faster and stronger immune response upon reinfection.
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Self-Antigen: Body's own biological material; immune system ignores these, but destroys cells binding to them.
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Skin: Physical barrier against pathogens.
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Spleen: Filters blood; removes old red blood cells, contains immune components.
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Stem Cell: Potentially differentiating into many different cell types, like immune cells and red blood cells.
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T Cell: Adaptive immune cell responding to specific pathogens, differentiating into helper or cytotoxic T cells.
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T Cell Receptor (TCR): Binds specific antigens (presented by MHC).
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Thymus: Site of T cell maturation.
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Tonsils: Small organs in the throat containing immune cells that fight inhaled/ingested microbes.
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Toxins: Harmful substances from living organisms.
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Vaccine: Substance triggering an immune response without causing disease; creating memory cells for future protection.
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Pathogen-associated molecular patterns (PAMPs): Recognized by the innate immune system.
Innate Immune Response
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First Responders: Phagocytes (neutrophils and macrophages) recognizing and engulfing pathogens via phagocytosis. Destroy infected cells.
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Inflammation: Triggered by pathogens; Mast cells release histamine causing blood vessel leakage; macrophages release cytokines, and more immune cells arrive. Redness, swelling, heat, and pain. Fever to combat infection.
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Antiviral Defense: Natural Killer (NK) cells destroy infected/abnormal cells.
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Antigen Presentation: Phagocytes (dendritic cells) present pathogen antigens via MHC proteins, activating adaptive immune response.
Adaptive Immune Response
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T-cell Activation: Activated when T cells encounter antigen-presenting cells.
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Antibody Production: B cells activated by helper T cells. B cells differentiate into plasma cells making specific antibodies. Antibodies target pathogens.
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Memory: Some B/T cells become memory cells; Faster, stronger responses upon reinfection.
Repeated Infections
- Secondary Immune Response: Faster response to re-infection due to memory cells.
Vaccines
- Vaccine Types: Live-attenuated, inactivated, subunit/recombinant, toxoid.
- mRNA Vaccines: Use mRNA to instruct cells to make viral proteins; body develops an immune response.
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Description
Explore the intricate anatomy of the immune system, focusing on barriers to infection, key organs, and cell development processes. Understand how skin, mucus, and stomach acid serve as defenses, and learn about the critical roles of bone marrow, thymus, and lymph nodes in immune function.