Immune System Anatomy
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Questions and Answers

Which of the following is NOT a physical barrier to infection?

  • Saliva
  • Mucus
  • Skin
  • Bone marrow (correct)
  • What is the primary role of the thymus in the immune system?

  • Maturation of B cells
  • Production of red blood cells
  • Maturation of T cells (correct)
  • Filtering of lymph fluid
  • Which cell type is responsible for producing antibodies?

  • T cells
  • Plasma cells (correct)
  • Phagocytes
  • Dendritic cells
  • What is the function of lymph nodes in the immune system?

    <p>To provide a site for immune cells to attack pathogens (A)</p> Signup and view all the answers

    What is the role of the bone marrow in the immune system?

    <p>Production of immune cells (A)</p> Signup and view all the answers

    Which of the following describes the spleen's function?

    <p>Removal of old or damaged blood cells (A)</p> Signup and view all the answers

    What is the function of a T cell receptor (TCR)?

    <p>To bind to pathogen antigens (B)</p> Signup and view all the answers

    What is the significance of removing self-reactive T and B cells during their development?

    <p>To prevent the immune system from attacking the body's own cells (B)</p> Signup and view all the answers

    Which process describes how a cell self-destructs?

    <p>Apoptosis (A)</p> Signup and view all the answers

    What is the primary role of B cells in the immune response?

    <p>Producing antibodies to target specific pathogens (A)</p> Signup and view all the answers

    Which of the following molecules is NOT typically recognized by the immune system as an antigen?

    <p>Water (D)</p> Signup and view all the answers

    Which type of cell is responsible for directly killing infected cells by triggering apoptosis?

    <p>Cytotoxic T cell (C)</p> Signup and view all the answers

    Which immune cells are primarily responsible for inducing apoptosis in virus-infected cells?

    <p>Natural killer cells (D)</p> Signup and view all the answers

    What is the function of histamine in the inflammatory response?

    <p>To make blood vessels more permeable (B)</p> Signup and view all the answers

    What is the role of MHC proteins in the adaptive immune response?

    <p>Presenting pathogen antigens on cell surfaces (B)</p> Signup and view all the answers

    Which immune cell acts as an antigen-presenting cell (APC) and is crucial for activating T cells?

    <p>Dendritic cell (B)</p> Signup and view all the answers

    Which type of immune response is characterized by its specificity and the development of memory?

    <p>Adaptive immune response (A)</p> Signup and view all the answers

    Where do immune cells, and red blood cells develop?

    <p>Bone marrow (D)</p> Signup and view all the answers

    What is the primary function of cytotoxic T cells?

    <p>Destroying infected cells (C)</p> Signup and view all the answers

    Which of the following best describes the role of cytokines in the immune system?

    <p>They act as signaling molecules for cell communication. (A)</p> Signup and view all the answers

    What is the role of plasma cells in the humoral immune response?

    <p>Producing antibodies (C)</p> Signup and view all the answers

    Which of the following initiates an adaptive immune response?

    <p>An antigen-MHC complex (A)</p> Signup and view all the answers

    Memory cells provide which critical benefit to the immune system?

    <p>They generate a faster and stronger response upon re-infection (C)</p> Signup and view all the answers

    What is the primary function of the major histocompatibility complex (MHC) protein?

    <p>Binding to an antigen and displaying it on cell surfaces. (D)</p> Signup and view all the answers

    Which of the following best distinguishes the innate from the adaptive immune response?

    <p>The speed of response (A)</p> Signup and view all the answers

    What is the primary difference between a primary and secondary immune response?

    <p>The secondary response involves memory cells, the primary does not (B)</p> Signup and view all the answers

    What is the purpose of using a live-attenuated vaccine?

    <p>To use a weakened form of the pathogen (A)</p> Signup and view all the answers

    What fluid circulates through the body in lymphatic vessels?

    <p>Lymph (D)</p> Signup and view all the answers

    An autoimmune disease occurs when the immune system mistakenly attacks...

    <p>The body’s own healthy cells (C)</p> Signup and view all the answers

    Which type of vaccine uses genetic material to instruct cells to produce a viral protein?

    <p>mRNA vaccine (B)</p> Signup and view all the answers

    What is the role of complement proteins in the immune response?

    <p>Helping to destroy pathogens and infected cells (A)</p> Signup and view all the answers

    If a person receives a vaccine, how does their immune system respond when they later encounter the same pathogen?

    <p>It mounts a faster and stronger secondary response (C)</p> Signup and view all the answers

    What is the primary function of helper T cells?

    <p>Activating other immune cells (B)</p> Signup and view all the answers

    What is the primary function of mucous membranes?

    <p>To provide a physical barrier and produce mucus to trap pathogens. (B)</p> Signup and view all the answers

    Which type of cell is responsible for releasing histamine?

    <p>Mast cells (C)</p> Signup and view all the answers

    What is the process by which phagocytes engulf and destroy pathogens?

    <p>Phagocytosis (B)</p> Signup and view all the answers

    What is the key characteristic of a secondary immune response compared to a primary immune response?

    <p>It is faster and more powerful. (B)</p> Signup and view all the answers

    Which of the following is an example of a pathogen?

    <p>Bacteria (D)</p> Signup and view all the answers

    What role do natural killer (NK) cells play in the immune system?

    <p>They kill infected and abnormal cells. (B)</p> Signup and view all the answers

    What is the function of plasma cells?

    <p>To produce antibodies. (D)</p> Signup and view all the answers

    What is the definition of a self-antigen?

    <p>A piece of biological material that is part of the body’s cells (D)</p> Signup and view all the answers

    Which cell type is the first responder for the innate immune system?

    <p>Neutrophils (C)</p> Signup and view all the answers

    What is the role of T cell receptors (TCR)?

    <p>To bind to specific antigens on antigen-presenting cells. (A)</p> Signup and view all the answers

    What is the function of memory cells in the adaptive immune system?

    <p>To provide a faster, stronger response upon reinfection. (B)</p> Signup and view all the answers

    What function do PAMPs serve in immunity?

    <p>They are used to distinguish self from non-self. (B)</p> Signup and view all the answers

    Which of the following best describes the purpose of a vaccine?

    <p>To trigger an immune response without causing infection. (D)</p> Signup and view all the answers

    Which of these is a phagocytic cell?

    <p>Neutrophil (C)</p> Signup and view all the answers

    Where do lymphoid progenitor cells differentiate to?

    <p>They differentiate into lymphocytes. (A)</p> Signup and view all the answers

    Flashcards

    The Skin's Role in Immunity

    The outer layer of the skin, composed of dead cells, acts as a physical barrier to prevent pathogens from entering the body.

    Mucus's Defensive Role

    Sticky mucus traps invading pathogens in the respiratory and digestive systems, preventing them from reaching deeper tissues.

    Saliva and Sweat's Immune Function

    Saliva and sweat contain enzymes and antibodies that can directly destroy pathogens.

    Stomach Acid: A Microbial Killer

    The stomach's acidic environment kills many of the pathogens we ingest with food and drinks.

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    Where are Immune Cells Created?

    This spongy tissue in bones is the birthplace of blood cells, including immune cells.

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    Lymphoid Progenitors: Building the Immune Response

    Immune cells that develop from lymphoid progenitor cells, including T cells and NK cells, are responsible for attacking pathogens.

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    The Thymus's Role in Immunity

    A specialized organ where T cells mature and learn to recognize and attack pathogens, while eliminating self-reactive cells.

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    Lymph Nodes: Filtering and Fighting Pathogens

    Lymph nodes, connected by lymphatic vessels, filter lymph and are crucial locations for immune cells to encounter and destroy pathogens.

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    What do NK cells do?

    NK cells kill infected or abnormal cells, including cancer cells, by causing them to die (apoptosis).

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    What do dendritic cells do?

    Dendritic cells display pathogen antigens on their surface using MHC proteins.

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    What is Adaptive Immunity?

    Adaptive immunity is specific and powerful. It targets specific antigens and remembers past infections for faster responses.

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    What are T cells and how do they work?

    T cells bind to specific antigens with their TCRs. They are activated by antigen-presenting cells and can become helper or cytotoxic T cells.

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    What do activated T cells do?

    Activated T cells rapidly divide and can become helper T cells (which activate other immune cells) or cytotoxic T cells (which destroy infected cells).

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    What are B cells and how are they activated?

    B cells bind to specific antigens with their BCRs. When activated by helper T cells, they become plasma cells that produce antibodies.

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    What is the function of antibodies?

    Antibodies bind to pathogens, neutralize toxins, and activate complement proteins to help destroy pathogens.

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    What are memory cells?

    Memory cells remember past infections and respond quickly if the same pathogen invades again.

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    What is the purpose of a vaccine?

    A vaccine triggers a primary immune response without causing disease, producing memory cells for faster responses to future infections.

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    How do mRNA vaccines work?

    mRNA vaccines use mRNA to teach cells how to make a protein found on a virus, stimulating an immune response.

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    Vaccine

    A substance that triggers an immune response against a pathogen without causing an infection. If the immune system encounters the same type of pathogen later, it can destroy the pathogen more quickly and efficiently.

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    Toxins

    Harmful substances (typically small molecules or proteins) produced by living organisms, including some pathogens.

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    Tonsils

    Small organs at the back of the throat that contain immune cells. These cells destroy inhaled or ingested microbes and warn the immune system about potential infections.

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    Thymus

    An organ in the chest where immune cells called T cells develop.

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    T cell receptor (TCR)

    A protein on the surface of a T cell that binds to a specific antigen (but only when the antigen is bound to an MHC protein on an antigen-presenting cell). Plays a major role in T cell activation.

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    T cell

    An adaptive immune cell that helps the body respond to specific pathogens. Upon recognizing a specific antigen, T cells differentiate into helper T cells and cytotoxic T cells.

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    Stem cell

    A cell that can develop into a variety of other cell types. Stem cells in the bone marrow can develop into immune cells and red blood cells.

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    Spleen

    An organ above the stomach that helps filter the blood. Contains immune cells that break down dead and dying red blood cells to recycle their parts.

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    Skin

    The body’s thick outer layer. Acts as a physical barrier to pathogens and also makes some antimicrobial substances.

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    Self-antigen

    A small piece of biological material (protein, carbohydrate, lipid, or nucleic acid) that is part of the body or its cells. The body destroys immune cells that bind to self-antigens.

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    Secondary immune response

    How the immune system responds the second (or any subsequent) time it encounters a specific pathogen. This response is faster and more powerful than the immune system response when it first encounters the pathogen.

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    Receptors

    Proteins in and on the membranes of cells. Receptors bind to specific molecules, such as antigens, to send signals between or within cells.

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    Progenitor cells

    Cells that come from stem cells and can then differentiate into other cell types. Lymphoid progenitor cells differentiate into lymphocytes, and myeloid progenitor cells differentiate into other immune cells and red blood cells. Both types of progenitor cells come from stem cells in the bone marrow.

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    Antigen

    A small piece of biological material, like a protein or carbohydrate, that the immune system can recognize. Antigens from pathogens or abnormal cells trigger an immune response.

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    Antigen-MHC complex

    An antigen bound to an MHC protein on the surface of a cell. T cells must bind to a specific antigen-MHC complex in order to activate.

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    Antigen-presenting cell (APC)

    A cell with an antigen bound to an MHC protein on its surface. APCs interact with T cells to trigger an immune response. The most common APCs are dendritic cells.

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    Apoptosis

    A process by which a cell destroys itself. It involves chemical reactions that make the cell change appearance and then die. Apoptosis is often used to kill cells that are unneeded or abnormal.

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    Autoimmune disease

    A condition where the immune system mistakenly attacks the body's healthy cells. The immune system can't tell friend from foe.

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    Basophil

    A type of immune cell that circulates in the blood and is involved in inflammation. It releases chemicals that promote inflammation.

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    Bone marrow

    A spongy tissue found in certain bones. It produces stem cells that develop into immune cells and red blood cells.

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    Cell-mediated immune response

    The processes of the adaptive immune response that destroy infected cells using cytotoxic T cells.

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    Complement proteins

    A group of proteins in the blood that help destroy pathogens and infected cells. They can directly damage pathogens or attract other immune cells to the site of an infection.

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    Cytokines

    Small proteins released by cells to communicate with other cells. They help regulate the immune response by alerting cells to an infection or activating specific immune cells.

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    Cytotoxic T cell

    A type of T cell that kills infected cells by inducing apoptosis. They are like the special forces of the immune system, targeting and destroying infected cells.

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    Dendritic cell

    A type of phagocyte (a cell that engulfs and destroys pathogens) that

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    Digestive system

    The organs and tissues involved in eating and breaking down food, absorbing nutrients, and eliminating waste. The digestive system also plays a role in the immune system as it is the first line of defense against pathogens that enter the body through food and water.

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    Study Notes

    Immune System Anatomy

    • Barriers to Infection:

      • Skin: Forms a physical barrier; outer layer composed of dead cells.
      • Mucus: Traps pathogens and protects mucous membranes (respiratory & digestive).
      • Saliva & Sweat: Contain antibodies and enzymes to destroy pathogens.
      • Stomach Acid: Kills many pathogens ingested.
    • Bone Marrow:

      • Spongy tissue in bones; site of blood stem cell production.
      • Creates red blood cells and immune cells.
      • Stem cells differentiate into lymphoid (T, B, NK cells) and myeloid (red blood cells, phagocytes).
      • B cells mature in the bone marrow.
    • Thymus:

      • T cells develop here, migrating from bone marrow.
      • T cells produce T cell receptors (TCRs) that bind pathogen antigens.
      • T cells that recognize self-antigens are destroyed.
    • Lymph Nodes:

      • Scattered throughout the body; connected by lymphatic vessels.
      • Lymph (tissue fluid) travels through lymphatic vessels to lymph nodes.
      • Immune cells (B cells, T cells, phagocytes) attack pathogens here.
    • Spleen:

      • Removes old/damaged blood cells using phagocytes (dendritic cells, macrophages).
      • Contains B and T cells to fight pathogens.
      • Functions can be taken over by other lymphoid organs if damaged.

    Immune System Activation & Response

    • Activation: A process where a cell changes function in response to a stimulus.

    • Adaptive Immune Cell: Include B cells and T cells. Involved in the adaptive immune response.

    • Adaptive Immune Response:

      • Provides long-lasting pathogen-specific protection.
      • Response takes time to develop.
    • Antibody:

      • A protein binding a specific antigen.
      • Produced by plasma cells.
      • Helps neutralize pathogens.
    • Antigen: Small biological material (protein, carbohydrate, lipid, nucleic acid) recognizable by the immune system.

      • Triggers an immune response if from a pathogen or abnormal cell.
    • Antigen-MHC Complex:

      • Antigen bound to MHC protein on the cell surface.
      • T cells need to bind to specific antigen-MHC complex for activation.
    • Antigen-Presenting Cell (APC):

      • Cell displaying an antigen bound to an MHC protein on its surface.
      • Dendritic cells are common APCs.
      • Interact with T cells to trigger an immune response
    • Apoptosis: Cell self-destruction, essential for removing unwanted or abnormal cells.

    • Autoimmune Disease: Immune system attacks healthy body cells.

    • Basophil: Innate immune cell; involved in inflammation.

    • B Cell: Adaptive immune cell targeting and destroying pathogens; differentiate into plasma cells upon T cell activation.

    • B Cell Receptor (BCR): Protein on B cells binding specific antigens; key in B cell activation.

    • Cell-Mediated Immune Response: Adaptive immune response targeting infected cells via cytotoxic T cells.

    • Complement Proteins: Blood proteins assisting pathogen destruction.

    • Cytokines: Signaling proteins between cells. Some alert or activate immune cells.

    • Cytotoxic T Cell: A type of T cell killing infected cells via apoptosis.

    • Dendritic Cell: Phagocyte that displays pathogen antigens to activate other immune cells.

    • Differentiation: Change from one cell type to another, often more specialized, triggered by cytokines and hormones.

    • Eosinophil: Innate immune cell; eliminates large pathogens (parasites) through chemical signals and damage.

    • Engulfing: Phagocytes engulfing particles, forming a vesicle.

    • Helper T Cell: T cell activating other immune cells (B cells and cytotoxic T cells).

    • Histamine: Released by mast cells; triggers inflammation by making blood vessels leaky.

    • Humoral Immune Response: Adaptive response involving antibodies, activating B cells.

    • Immune Response: The immune system's process fighting pathogens.

    • Immunocompromised: Weakened immune system efficiency.

    • Inflammation: Innate response fighting pathogens and repairing tissue damage.

    • Innate Immune Cell: Include phagocytes (macrophages, neutrophils, dendritic cells), mast cells, and NK cells.

    • Innate Immune Response: Immediate, broad-spectrum protection—recognizes generalized pathogen components, not specific ones.

    • Lymph: Fluid similar to blood (no red blood cells), containing immune cells.

    • Lymphatic Vessels: Carry lymph throughout the body.

    • Lymphocyte: Immune cell type (T cells, B cells, NK cells).

    • Lymphoid Organs: Produce and contain immune cells (bone marrow, thymus, lymph nodes, spleen, tonsils).

    • Macrophage: Phagocyte; engulfing and destroying pathogens and abnormal cells; releasing chemical signals (cytokines).

    • Major Histocompatibility Complex (MHC) protein: Binds to antigens and displays them; critical for T cell activation.

    • Mast Cell: Innate immune cell essential for inflammation, releasing chemical signals.

    • Memory Cells: Long-lived B and T cells; quick immune response to subsequent infections.

    • Microbe: Microscopic organism; some helpful, some pathogenic.

    • Microbiome: Community of microbes living in/on the body; usually non-pathogenic.

    • Monocyte: Innate cell differentiating into macrophages.

    • Mucus Membrane: Thin tissue with mucus-producing cells; lining several systems (e.g., digestive, respiratory).

    • Mucus: Sticky substance; protecting tissues and containing antimicrobial components.

    • Natural Killer (NK) Cell: Innate immune cell killing infected/abnormal cells.

    • Neutralization: Antibodies blocking pathogen interaction with body cells.

    • Neutrophil: Innate immune cell; responding first to pathogens(bacteria and fungi).

    • Pathogen: Disease-causing microbe.

    • Phagocyte: Engulfing and destroying pathogens; includes neutrophils, monocytes, macrophages, dendritic cells.

    • Phagocytosis: The process of engulfing and destroying pathogens and abnormal cells.

    • Plasma Cell: Adaptive immune cell producing antibodies.

    • Primary Immune Response: Initial immune system response to a pathogen.

    • Progenitor Cells: Develop from stem cells; differentiating into other cell types.

    • Receptor: Cell membrane proteins binding specific molecules for cell signaling.

    • Secondary Immune Response: Faster and stronger immune response upon reinfection.

    • Self-Antigen: Body's own biological material; immune system ignores these, but destroys cells binding to them.

    • Skin: Physical barrier against pathogens.

    • Spleen: Filters blood; removes old red blood cells, contains immune components.

    • Stem Cell: Potentially differentiating into many different cell types, like immune cells and red blood cells.

    • T Cell: Adaptive immune cell responding to specific pathogens, differentiating into helper or cytotoxic T cells.

    • T Cell Receptor (TCR): Binds specific antigens (presented by MHC).

    • Thymus: Site of T cell maturation.

    • Tonsils: Small organs in the throat containing immune cells that fight inhaled/ingested microbes.

    • Toxins: Harmful substances from living organisms.

    • Vaccine: Substance triggering an immune response without causing disease; creating memory cells for future protection.

    • Pathogen-associated molecular patterns (PAMPs): Recognized by the innate immune system.

    Innate Immune Response

    • First Responders: Phagocytes (neutrophils and macrophages) recognizing and engulfing pathogens via phagocytosis. Destroy infected cells.

    • Inflammation: Triggered by pathogens; Mast cells release histamine causing blood vessel leakage; macrophages release cytokines, and more immune cells arrive. Redness, swelling, heat, and pain. Fever to combat infection.

    • Antiviral Defense: Natural Killer (NK) cells destroy infected/abnormal cells.

    • Antigen Presentation: Phagocytes (dendritic cells) present pathogen antigens via MHC proteins, activating adaptive immune response.

    Adaptive Immune Response

    • T-cell Activation: Activated when T cells encounter antigen-presenting cells.

    • Antibody Production: B cells activated by helper T cells. B cells differentiate into plasma cells making specific antibodies. Antibodies target pathogens.

    • Memory: Some B/T cells become memory cells; Faster, stronger responses upon reinfection.

    Repeated Infections

    • Secondary Immune Response: Faster response to re-infection due to memory cells.

    Vaccines

    • Vaccine Types: Live-attenuated, inactivated, subunit/recombinant, toxoid.
    • mRNA Vaccines: Use mRNA to instruct cells to make viral proteins; body develops an immune response.

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    Description

    Explore the intricate anatomy of the immune system, focusing on barriers to infection, key organs, and cell development processes. Understand how skin, mucus, and stomach acid serve as defenses, and learn about the critical roles of bone marrow, thymus, and lymph nodes in immune function.

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