Immune System Activation Mechanisms Quiz
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Questions and Answers

What is the most likely consequence of C5a activation on mast cells in the context of an allergic reaction?

  • Decreased cytokine release
  • Increased itching (correct)
  • Decreased histamine release
  • Increased inflammation
  • In delayed-type hypersensitivity, what is the role of T regulatory (Treg) cells as hapten levels drop?

  • Activating mast cells
  • Inducing vasodilation
  • Promoting wound healing (correct)
  • Enhancing inflammation
  • What type of immune response is predominantly generated in granulomatous hypersensitivity?

  • CD8+ cell response
  • Th2 cell response
  • CD4+ Th1 cell response (correct)
  • Macrophage-mediated response
  • What happens to airway macrophages upon uptake of bacteria in chronic infections?

    <p>Penetration into underlying tissues</p> Signup and view all the answers

    Which of the following does NOT contribute to the pathophysiology of granulomatous hypersensitivity?

    <p>Treg cell activation</p> Signup and view all the answers

    How do reactive oxygen and nitrogen species (ROS, RNS) contribute to skin redness, inflammation, and blistering?

    <p>By degrading DNA</p> Signup and view all the answers

    Which of the following best describes the process that allows a quarantined microbe to escape the fibrous capsule within a granuloma?

    <p>The microbe gains access to the airway by lysis of infected macrophages.</p> Signup and view all the answers

    In Type IV hypersensitivity reactions, what is the role of dendritic cells (DC) in the immune response?

    <p>DC present self-antigens to CD4+ and CD8+ T cells.</p> Signup and view all the answers

    What contributes to the recruitment of neutrophils and monocytes into the tissue during a Type IV hypersensitivity reaction?

    <p>Local inflammation triggered by macrophage and mast cell activation</p> Signup and view all the answers

    How do self-reactive T cells persist in lymph nodes and spleen in Type IV hypersensitivity reactions?

    <p>By escaping tolerance mechanisms in the thymus</p> Signup and view all the answers

    What causes infected macrophages within a granuloma to release viable bacteria into the tissue and airway?

    <p>Escape of bacteria through lysis of infected macrophages</p> Signup and view all the answers

    What is one of the main consequences of foamy cells becoming more susceptible to infection by a pathogen?

    <p>Decrease in lipid levels within foamy cells</p> Signup and view all the answers

    Which process leads to the release of mediators into the environment such as prostaglandins and chemokines?

    <p>Frustrated phagocytosis</p> Signup and view all the answers

    What can lead to the formation of microthrombi in blood vessels by inducing platelet aggregation?

    <p>Platelet activating factor (PAF)</p> Signup and view all the answers

    What is a key process that can contribute to tissue necrosis due to prolonged activation of phagocytes?

    <p>IC formation</p> Signup and view all the answers

    In the context provided, what is a characteristic feature of Rheumatoid Arthritis (RA)?

    <p>Presence of high levels of Rheumatoid Factor (RF)</p> Signup and view all the answers

    Which statement is true regarding the susceptibility factors for Systemic Lupus Erythematosus (SLE)?

    <p>HLA-DR4 confers the greatest susceptibility to SLE.</p> Signup and view all the answers

    Which process contributes to the chronic disease setting often resulting in death in SLE patients?

    <p>Epitope spreading</p> Signup and view all the answers

    In Type IV hypersensitivity reactions, what is a key characteristic of the effector stage of contact hypersensitivity?

    <p>Participation of CD8+ T cells in tissue inflammation through various mechanisms</p> Signup and view all the answers

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