Immune Responses vs Tumor Growth
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Questions and Answers

Which receptor on naive T cells is preferentially engaged by dendritic cells that capture tumor antigens?

  • CD28
  • PD-1
  • CTLA-4 (correct)
  • B7
  • What is the function of myeloid-derived suppressor cells in tumors?

  • Promote antitumor immune responses
  • Express high levels of B7 costimulators
  • Engage the stimulatory receptor CD28
  • Secrete immunosuppressive cytokines (correct)
  • Which cytokine may be secreted by some tumors to induce immunosuppression?

  • BCG
  • Transforming growth factor β (correct)
  • CAR
  • Interleukin-2
  • Which of the following is a mechanism used by tumors to avoid destruction by the immune system?

    <p>Expression of PD-L1</p> Signup and view all the answers

    Why do immune responses often fail to check tumor growth?

    <p>Tumors do not display antigens to CD8+ T cells</p> Signup and view all the answers

    Why do T cells specific for tumor antigens become unresponsive to antigen?

    <p>They develop an exhausted state</p> Signup and view all the answers

    Which mechanism do tumors use to avoid destruction by the immune system?

    <p>Tumors stop expressing class I MHC molecules</p> Signup and view all the answers

    Why do immune responses often fail to check tumor growth?

    <p>Tumors grow rapidly</p> Signup and view all the answers

    What happens to T cells when they are repeatedly stimulated by persistent tumors?

    <p>T cells develop an exhausted state</p> Signup and view all the answers

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