Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
Which receptor on naive T cells is preferentially engaged by dendritic cells that capture tumor antigens?
Which receptor on naive T cells is preferentially engaged by dendritic cells that capture tumor antigens?
- CD28
- PD-1
- CTLA-4 (correct)
- B7
What is the function of myeloid-derived suppressor cells in tumors?
What is the function of myeloid-derived suppressor cells in tumors?
- Promote antitumor immune responses
- Express high levels of B7 costimulators
- Engage the stimulatory receptor CD28
- Secrete immunosuppressive cytokines (correct)
Which cytokine may be secreted by some tumors to induce immunosuppression?
Which cytokine may be secreted by some tumors to induce immunosuppression?
- BCG
- Transforming growth factor β (correct)
- CAR
- Interleukin-2
Which of the following is a mechanism used by tumors to avoid destruction by the immune system?
Which of the following is a mechanism used by tumors to avoid destruction by the immune system?
Signup and view all the answers
Why do immune responses often fail to check tumor growth?
Why do immune responses often fail to check tumor growth?
Signup and view all the answers
Why do T cells specific for tumor antigens become unresponsive to antigen?
Why do T cells specific for tumor antigens become unresponsive to antigen?
Signup and view all the answers
Which mechanism do tumors use to avoid destruction by the immune system?
Which mechanism do tumors use to avoid destruction by the immune system?
Signup and view all the answers
Why do immune responses often fail to check tumor growth?
Why do immune responses often fail to check tumor growth?
Signup and view all the answers
What happens to T cells when they are repeatedly stimulated by persistent tumors?
What happens to T cells when they are repeatedly stimulated by persistent tumors?
Signup and view all the answers
