7 Questions
Which approach is a modification of adoptive T cell therapy that uses viral vectors to express a chimeric antigen receptor (CAR)?
Chimeric antigen receptor (CAR) expressing T cells
What is the likely reason for inconsistent results of adoptive T cell therapy with autologous tumor-specific T cells?
Low frequency of tumor-specific T cells
What is the function of chimeric antigen receptor (CAR) in CAR-expressing T cells?
Activates the T cells and enhances their proliferation
Which of the following is true about CAR-T cell therapy?
CAR-T cells can be used in patients with different HLA alleles
What is the main function of the intracellular signaling domains in CAR-T cells?
Activating signals
What is the most serious toxicity associated with CAR-T cell therapy?
Cytokine release syndrome
Why has CAR-T cell therapy not been successful in solid tumors?
T cells cannot access solid tumor sites
Test your knowledge of adoptive T cell therapy in tumor immunology. Learn about the various approaches used to enhance antitumor immunity through the activation and transfer of tumor-specific T cells.
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