Adoptive T Cell Therapy in Tumor Immunology Quiz
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Questions and Answers

Which approach is a modification of adoptive T cell therapy that uses viral vectors to express a chimeric antigen receptor (CAR)?

  • Adoptive therapy with autologous tumor-specific T cells
  • Enhancing antitumor immunity
  • Chimeric antigen receptor (CAR) expressing T cells (correct)
  • Activating T cells ex vivo
  • What is the likely reason for inconsistent results of adoptive T cell therapy with autologous tumor-specific T cells?

  • Low frequency of tumor-specific T cells (correct)
  • Lack of T cell-stimulating cytokines
  • Insufficient expansion of T cell population
  • Ineffective migration of activated CTLs into the tumor
  • What is the function of chimeric antigen receptor (CAR) in CAR-expressing T cells?

  • Isolates T cells from the blood or tumor biopsies
  • Stimulates the production of growth factors
  • Recognizes tumor antigens and destroys them
  • Activates the T cells and enhances their proliferation (correct)
  • Which of the following is true about CAR-T cell therapy?

    <p>CAR-T cells can be used in patients with different HLA alleles</p> Signup and view all the answers

    What is the main function of the intracellular signaling domains in CAR-T cells?

    <p>Activating signals</p> Signup and view all the answers

    What is the most serious toxicity associated with CAR-T cell therapy?

    <p>Cytokine release syndrome</p> Signup and view all the answers

    Why has CAR-T cell therapy not been successful in solid tumors?

    <p>T cells cannot access solid tumor sites</p> Signup and view all the answers

    Study Notes

    Adoption of CAR-T Cell Therapy

    • Viral Vectors and CAR: The approach involves using viral vectors to express a chimeric antigen receptor (CAR), enhancing the effectiveness of adoptive T cell therapy.

    Inconsistencies in Autologous T Cell Responses

    • Variability in Responses: Inconsistent results with autologous tumor-specific T cells are often due to factors like tumor heterogeneity and T cell dysfunction within the tumor microenvironment.

    Role of Chimeric Antigen Receptor (CAR)

    • Targeting Mechanism: CARs on T cells enable the recognition of specific antigens presented by cancer cells, enhancing the targeted attack against tumors.

    CAR-T Cell Therapy Insights

    • General Outcome: CAR-T cell therapy has shown effective results in hematological malignancies but faces challenges in solid tumors.

    Function of Intracellular Signaling Domains

    • Activation and Proliferation: The intracellular signaling domains in CAR-T cells are crucial for activating T cells, promoting their proliferation, and instructing them to kill targeted cancer cells.

    Serious Toxicity Concerns

    • Cytokine Release Syndrome: The most serious toxicity associated with CAR-T cell therapy is cytokine release syndrome (CRS), which can lead to severe complications if not managed promptly.

    Challenges in Solid Tumor Therapy

    • Obstacles in Efficacy: The limited success of CAR-T cell therapy in solid tumors is attributed to factors like the lack of suitable tumor-specific antigens, immunosuppressive tumor microenvironments, and physical barriers surrounding the tumors.

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    Description

    Test your knowledge of adoptive T cell therapy in tumor immunology. Learn about the various approaches used to enhance antitumor immunity through the activation and transfer of tumor-specific T cells.

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