6 Questions
Which cells transport alloan- tigens from the graft to draining lymph nodes?
Dendritic cells
What is the process called when naïve T cells in the recipient recognize donor allogeneic MHC molecules on graft-derived dendritic cells?
Direct recognition
How are donor alloantigens processed and presented to T cells in the indirect allorecognition pathway?
By recipient APCs
What is the main role of alloreactive CD4+ T cells in graft rejection?
Secreting cytokines that injure the graft
What is the mixed lymphocyte reaction (MLR) used for?
Assaying the responses of T cells to alloantigens
Which type of T cell recognition is considered direct allorecognition?
Recognition of allogeneic MHC molecules by T lymphocytes
Test your knowledge on the immune response to allografts and the role of dendritic cells in presenting alloantigens to T cells. Explore the process of antigen recognition, costimulation, and the generation of effector T cells.
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