Immune Response Cytokines

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What is the primary role of IL-1?

Upregulates RNase activity to control viral infection

Stimulates acute-phase protein synthesis

Upregulates inflammatory response, including fever (correct)

Enhances antigen recognition by T and B cells

Which cells are the primary source of IL-2?

T cells (correct)

All somatic cells

Monocytes and macrophages

Macrophages and dendritic cells

What is the role of IL-4 in the immune response?

Stimulates IL-1, IL-6, TNF, and chemokine production

T-cell subset and mast cells (correct)

Enhances antigen recognition by T and B cells

Upregulates inflammatory response, including fever

Which cytokine is involved in hematopoiesis and is produced by bone marrow and thymic stromal cells?

IL-7 Signup and view all the answers

What is the primary role of IFN-α?

Upregulates RNase activity to control viral infection Signup and view all the answers

Which cytokine is produced by macrophages and dendritic cells and plays a key role in innate resistance?

IL-23 Signup and view all the answers

What is the primary role of TNF-β?

Induces tumor regression Signup and view all the answers

Which cytokine is involved in innate resistance and is produced by all somatic cells?

IFN-α Signup and view all the answers

What is the primary role of CSF-1?

Stimulates osteoblasts Signup and view all the answers

What effect does IL-4 have on B cells?

Stimulates growth of B cells Signup and view all the answers

What is the primary function of IL-1?

Induces pro-inflammatory cytokines Signup and view all the answers

What is the effect of IL-5 on eosinophils?

Activates eosinophils Signup and view all the answers

What is the primary function of IL-2?

Stimulates growth and function of T-cell subsets Signup and view all the answers

What is the effect of IL-7 on hematopoietic stem cells?

Stimulates pluripotent hematopoietic stem cells to become lymphoid progenitor cells Signup and view all the answers

What is the primary function of IL-3?

Stimulates pluripotent hematopoietic stem cells to become myeloid progenitor cells Signup and view all the answers

What is the effect of IL-12 on the immune system?

Inhibits IL-12 production Signup and view all the answers

What is the primary function of GM-CSF?

Induces hematopoietic stem cells to proliferate and differentiate into granulocytes and monocytes Signup and view all the answers

What is the effect of G-CSF on hematopoietic stem cells?

Induces hematopoietic stem cells to proliferate and differentiate into neutrophils Signup and view all the answers

What is the primary function of M-CSF?

Induces hematopoietic stem cells to proliferate and differentiate into monocytes/macrophages Signup and view all the answers