24 Questions
During the primary immune response, what is the main function of effector cells/molecules?
End an infection
Which of the following best describes the primary goal of a successful primary immune response?
End an infection and create a reserve of memory B and T cells
What ensures that low affinity antibody is not produced in secondary immune responses?
Mechanism involving memory B cells
What is the concept of original antigenic sin related to?
Immunological memory and subsequent immune responses
What is the main function of immunological memory during a secondary immune response?
Faster and more potent response to clear infections
How is immunological memory developed during the latter stages of the primary immune response?
Through the generation of memory B and T cells
What is the process of maintaining a memory cell population primarily related to?
Sustaining immunological memory for future responses
In the context of B cells, what distinguishes a primary immune response from a secondary immune response?
Speed and potency of the response
What ensures that low affinity antibody is not produced in secondary immune responses?
Mechanism involving memory B cells
In the context of T cells, what distinguishes a primary immune response from a secondary immune response?
Speed and potency of the response
What is the primary goal of a successful primary immune response?
End an infection and create a reserve of memory B and T cells
What is the main function of effector cells/molecules during the primary immune response?
End an infection
Which cells maintain high antibody levels, preventing recurrence of seasonal diseases?
Long-lived plasma cells
What sustains immunological memory of a pathogen?
Memory T and B cells
Which cells are crucial during secondary immune responses?
Memory cells
What distinguishes memory B cells from naive B cells?
Isotype switched, high affinity, and can continue isotype switching/affinity maturation
Why is the activation of naive antigen-specific B cells suppressed during secondary immune responses?
Due to the binding of immune complexes to inhibitory receptors
What are the defining characteristics of memory B cells?
Isotype switched/affinity-matured receptors and CD27
What subsets of memory T cells are defined based on their characteristics and functions?
Central memory T cells and effector memory T cells
Which cells are more abundant and easily activated compared to naive lymphocytes?
Memory cells
What maintains high antibody levels in the bone marrow or beneath mucosal surfaces?
Long-lived plasma cells
Which cells sustain immunological memory of a pathogen?
Memory T and B cells
What distinguishes memory B cells from naive B cells?
Isotype switched, high affinity, and can continue isotype switching/affinity maturation
Why is the activation of naive antigen-specific B cells suppressed during secondary immune responses?
Due to the binding of immune complexes to inhibitory receptors
Study Notes
Immune Response and Memory Cells
- Primary immune response involves the formation of antibodies that prevent re-infection
- Successful primary immune response results in high levels of specific antibodies in blood, lymph, and mucosal surfaces for many months
- Long-lived plasma cells in the bone marrow or beneath mucosal surfaces maintain high antibody levels, preventing recurrence of seasonal diseases
- Long-lived memory T and B cells sustain immunological memory of a pathogen
- Memory cells, including memory CD8 T cells, memory CD4 T cells, and memory B cells, are crucial during secondary immune responses
- Memory cells are more abundant and easily activated compared to naive lymphocytes
- Memory B cells are isotype switched, high affinity, and can continue isotype switching/affinity maturation during subsequent infections
- Memory B cells express distinguishing features such as isotype switched/affinity-matured receptors and CD27
- The activation of naive antigen-specific B cells is suppressed during secondary immune responses due to the binding of immune complexes to inhibitory receptors
- Memory B cell responses in secondary immune responses are similar to and different from primary responses
- Memory T cell responses are similar to and different from primary responses, with differences in activation and circulation in peripheral tissues
- Two subsets of memory T cells, central memory T cells and effector memory T cells, are defined based on their characteristics and functions
Test your knowledge of the immune response and memory cells with this quiz. Explore the formation of antibodies, the role of memory T and B cells, and the differences between primary and secondary immune responses.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
