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Questions and Answers
Central memory T cells reside in the peripheral blood.
False
Effector memory T cells primarily circulate in lymph nodes.
False
T cells require only one signal for activation.
False
The TCR is responsible for binding to antigens presented by APCs.
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Central memory T cells directly kill infected cells by inducing necrosis.
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The main function of the TCR is signal reception and transmission within T cells.
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Central memory T cells recognize broad patterns on pathogens.
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Central memory T cells are a type of B cells.
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Innate immunity is responsible for creating antibodies.
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Memory cells do not improve with repeated exposure to a pathogen.
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Central memory T cells have a slower response time compared to innate immunity.
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Antigen-presenting cells like dendritic cells are part of innate immunity.
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CD4+ T cells are restricted by MHC class I.
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Memory T cells are a type of Regulatory T cells (Tregs).
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Peripheral T cells migrate to different lymphoid organs before activation by antigens.
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Th1 cells primarily enhance humoral immunity.
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CD markers are used to identify and characterize different cell types within the digestive system.
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Central Memory T Cells differentiate into effector T cells upon encountering antigens.
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Study Notes
T Cells and Memory Subtypes
- Central memory T cells reside in peripheral blood and have a slower response time compared to innate immunity.
- Effector memory T cells primarily circulate in lymph nodes and play a role in the immune response.
- T cells require only one signal for activation, with the T cell receptor (TCR) responsible for binding to antigens presented by antigen-presenting cells (APCs).
- Central memory T cells differentiate into effector T cells upon encountering antigens, enabling them to respond effectively to infections.
Central Memory T Cells Characteristics
- Central memory T cells recognize broad patterns on pathogens, which enhances their ability to respond to various infections.
- Contrary to claims, central memory T cells are not a type of B cells; they belong to the T cell lineage.
- Memory cells do not improve with repeated exposure to a pathogen, which differs from the behavior of antibodies in the response.
Role of TCR and Immune Response
- The main function of the TCR is signal reception and transmission within T cells, essential for initiating immune responses.
- CD4+ T cells, which play a crucial role in the immune system, are restricted by MHC class II molecules, not class I.
Immune System Interaction
- Innate immunity, involving components like dendritic cells, is responsible for creating antibodies and presenting antigens to T cells.
- Peripheral T cells migrate to different lymphoid organs for activation by antigens, enabling a coordinated immune response.
- Th1 cells primarily enhance humoral immunity, helping to bridge adaptive and innate immunity.
Cell Identification
- CD markers are utilized for identifying and characterizing various cell types within the immune system, assisting in the study of immune responses and functions.
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Description
Test your knowledge on central memory T cells (TCM) and effector memory T cells (TEM) as well as the activation of T cells. Learn about the functions of TCM and TEM, including their roles in immune response and immune tolerance.
