Imaging in Radiation Therapy
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Questions and Answers

What advantage does PET offer in radiation oncology compared to CT or MRI?

  • Higher sensitivity, specificity, and accuracy (correct)
  • Longer imaging time
  • Less radiation exposure
  • Lower cost of imaging

    • How can PET imaging affect treatment planning in radiation oncology?

  • It reduces the need for additional imaging techniques
  • It has no impact on treatment planning
  • It replaces the role of physical examination
  • It may change the delineation of the planning target volume (correct)

    • In the context of tumor delineation, what is one notable benefit of using PET?

  • It reduces interobserver variation in contouring (correct)
  • It is more time-consuming than traditional methods
  • It is a less accurate imaging modality
  • It eliminates interobserver variation completely

    • What is the significance of hypoxia imaging in relation to PET in radiation oncology?

    <p>It defines areas of tumor to potentially boost radiation dose</p> Signup and view all the answers

    What is the potential percentage of treatment volume alteration due to PET imaging?

    <p>25-50%</p> Signup and view all the answers

    What is the purpose of tattooing a patient in radiation therapy simulation?

    <p>To mark key locations for treatment delivery.</p> Signup and view all the answers

    What does conventional simulation in radiation therapy typically rely on?

    <p>External bony landmarks and internal bony structures.</p> Signup and view all the answers

    In conventional simulation, what type of unit is typically used?

    <p>X-ray unit mimicking treatment unit geometry.</p> Signup and view all the answers

    What is the significance of the isocentre in conventional simulation?

    <p>It is the point around which treatment beams are aligned.</p> Signup and view all the answers

    What does the term 100SAD refer to in radiation therapy?

    <p>A measure of the spatial distance from the source to the isocentre.</p> Signup and view all the answers

    What is a benefit of symmetrizing the field in radiation therapy?

    <p>To ensure uniform dose distribution.</p> Signup and view all the answers

    Why is it important to take pictures from all angles during conventional simulation?

    <p>To document setup and ensure accuracy in treatment delivery.</p> Signup and view all the answers

    What imaging technique is primarily utilized in conventional simulation for fluoroscopy?

    <p>X-ray imaging with an image intensifier.</p> Signup and view all the answers

    What is the recommended waiting period before performing FDG PET after radiotherapy?

    <p>2-3 months</p> Signup and view all the answers

    Which type of scans are performed as part of the patient monitoring protocol during radiotherapy?

    <p>Pre-RT, mid-RT, and post-RT scans</p> Signup and view all the answers

    What is a potential side effect of radiotherapy that might influence FDG PET results?

    <p>Hypermetabolism</p> Signup and view all the answers

    In the context of lung cancer, what is the purpose of acquiring FDG PET data during radiotherapy?

    <p>To assess tumor metabolic response for potential treatment adaptation</p> Signup and view all the answers

    Which types of lung cancer were included in the patient studies monitored with FDG PET?

    <p>Non-small cell lung cancer and small cell lung cancer</p> Signup and view all the answers

    What is the primary purpose of FDG uptake in functional imaging?

    <p>To measure glucose metabolism within cells</p> Signup and view all the answers

    Which process is responsible for the conversion of FDG to FDG-6-PO4?

    <p>Phosphorylation by hexokinase</p> Signup and view all the answers

    What is a key characteristic of GLUT transporters in tumor cells?

    <p>They have increased activity in many tumors</p> Signup and view all the answers

    How is the Standardized Uptake Value (SUV) calculated?

    <p>Tracers activity in tissue divided by patient weight and injected dose</p> Signup and view all the answers

    What type of quantification of FDG uptake allows for objective comparison in radiation oncology?

    <p>Absolute and semi-quantitative methods</p> Signup and view all the answers

    In the context of tumor cells, how does FDG uptake behave compared to glucose?

    <p>FDG uptake is elevated, indicating increased metabolism in tumor cells</p> Signup and view all the answers

    Which of the following applications is NOT a role of FDG-PET in oncology?

    <p>Monitoring respiratory rate during treatment</p> Signup and view all the answers

    How does FDG uptake reflect the metabolic activity inside a cell?

    <p>It is directly proportional to glucose levels in the cell</p> Signup and view all the answers

    What is classified as a Complete Response (CR) according to EORTC metabolic response criteria?

    <p>Complete resolution of FDG uptake within tumor volume</p> Signup and view all the answers

    Which outcome measure indicates that the tumor shows a significant increase in SUV, thus characterizing Progressive Disease (PD)?

    <p>More than 25% increase in SUV</p> Signup and view all the answers

    What does Stable Disease (SD) indicate in the context of EORTC metabolic response?

    <p>Increase in SUV of less than 25% or decrease of less than 15%</p> Signup and view all the answers

    What does the term 'PET tracer uptake' refer to in the monitoring of treatment response?

    <p>Measurement of metabolic activity in tumor cells</p> Signup and view all the answers

    What is a notable feature of 18F-FLT in relation to tumor response monitoring?

    <p>It helps visualize cells by lighting up when they are highly proliferative.</p> Signup and view all the answers

    Which imaging biomarkers are primarily used for assessing treatment response?

    <p>Volume metrics and metabolic uptake measurements</p> Signup and view all the answers

    What is the significance of the RECIST criteria in the context of imaging for treatment response?

    <p>It defines measurable changes in tumor size during treatment.</p> Signup and view all the answers

    Under which circumstances could a pre-treatment imaging scan indicate a need for therapy modification?

    <p>If the imaging indicates potential metastasis</p> Signup and view all the answers

    Study Notes

    Imaging in Radiation Therapy

    • Imaging modalities are used to assess tumors and disease in radiation therapy (RT) and for treatment planning and monitoring.
    • FDG-PET is a functional imaging modality that uses a radioactive tracer to detect areas of high metabolism.
    • FDG is a glucose analog that is taken up by cells in proportion to their glucose metabolic activity.
    • FDG PET is used in oncology for staging, treatment planning, and monitoring treatment response.
    • Standardized uptake value (SUV) is a semi-quantitative measure of FDG uptake that is used to assess tumor metabolism.
    • SUV is calculated by dividing the tracer activity in tissue by the injected dose and patient weight.
    • PET-CT combines the functional information of PET with the anatomical information of CT.
    • Contouring with PET can help to reduce inter-observer variation in PTV definition.
    • PET can alter the target volume in some tumor types, such as NSCLC.
    • Hypoxia imaging with PET can define areas of tumor that may need a higher dose of RT.
    • Treatment response is monitored with PET by following changes in FDG uptake or other tracers.
    • The EORTC metabolic response criteria are used to assess response to treatment based on FDG uptake.
    • 18F-FLT (18F-Fluorothymidine) is a PET tracer that is used to measure cell proliferation.
    • 18F-FLT can be used to monitor the response to chemotherapy treatment.
    • Clinical research is evaluating the use of FDG PET during RT to assess tumor metabolic response and potentially adapt treatment before completion.

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    Lecture 5 - Other Imaging Modalities - Imaging in Radiation Therapy PDF

    Description

    Explore the critical role of imaging modalities in radiation therapy, focusing on FDG-PET's use in tumor assessment and treatment monitoring. Understand the significance of standardized uptake value (SUV) and how PET-CT integrates functional and anatomical information. This quiz will enhance your knowledge of imaging's impact on oncology practices.

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