IL-6 and Acute Inflammation Quiz
10 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following cells synthesizes IL-6 in response to PAMPs and DAMPs?

  • Mononuclear phagocytes (correct)
  • Neutrophils
  • Eosinophils
  • Basophils
  • What is the function of IL-6 in the regulation of the immune system and the nervous system?

  • Promotes the differentiation of IL-17–producing helper T cells (correct)
  • Enhances the phagocytic activity of macrophages
  • Induces the synthesis of acute-phase reactants by the liver
  • Stimulates the production of IgE by B cells
  • Which protein does IL-6 bind to on target cells?

  • CD4 receptor
  • 80 kDa IL-6 receptor (IL-6R) (correct)
  • Fc receptor (FcR)
  • Toll-like receptor 4 (TLR4)
  • What is the role of gp130 in IL-6 signaling?

    <p>It dimerizes and initiates intracellular signaling</p> Signup and view all the answers

    Where is IL-6R predominantly expressed in the body?

    <p>Hepatocytes and some leukocytes</p> Signup and view all the answers

    Phagocytosed microbes are destroyed and peptides are generated from microbial proteins for adaptive immune responses.

    <p>True</p> Signup and view all the answers

    Activated neutrophils and macrophages kill phagocytosed microbes by the action of microbicidal molecules in phagolysosomes.

    <p>True</p> Signup and view all the answers

    Signals from various receptors, including pattern recognition receptors, opsonin receptors, receptors for cytokines, and CD40, function cooperatively to activate phagocytes to kill ingested microbes.

    <p>True</p> Signup and view all the answers

    Fusion of phagocytic vacuoles with lysosomes results in the formation of phagolysosomes, where most of the microbicidal mechanisms are concentrated.

    <p>True</p> Signup and view all the answers

    Activated neutrophils and macrophages primarily use reactive oxygen species (ROS) to kill ingested microbes.

    <p>False</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Browser