Podcast
Questions and Answers
Which of the following cells synthesizes IL-6 in response to PAMPs and DAMPs?
Which of the following cells synthesizes IL-6 in response to PAMPs and DAMPs?
- Mononuclear phagocytes (correct)
- Neutrophils
- Eosinophils
- Basophils
What is the function of IL-6 in the regulation of the immune system and the nervous system?
What is the function of IL-6 in the regulation of the immune system and the nervous system?
- Promotes the differentiation of IL-17–producing helper T cells (correct)
- Enhances the phagocytic activity of macrophages
- Induces the synthesis of acute-phase reactants by the liver
- Stimulates the production of IgE by B cells
Which protein does IL-6 bind to on target cells?
Which protein does IL-6 bind to on target cells?
- CD4 receptor
- 80 kDa IL-6 receptor (IL-6R) (correct)
- Fc receptor (FcR)
- Toll-like receptor 4 (TLR4)
What is the role of gp130 in IL-6 signaling?
What is the role of gp130 in IL-6 signaling?
Where is IL-6R predominantly expressed in the body?
Where is IL-6R predominantly expressed in the body?
Phagocytosed microbes are destroyed and peptides are generated from microbial proteins for adaptive immune responses.
Phagocytosed microbes are destroyed and peptides are generated from microbial proteins for adaptive immune responses.
Activated neutrophils and macrophages kill phagocytosed microbes by the action of microbicidal molecules in phagolysosomes.
Activated neutrophils and macrophages kill phagocytosed microbes by the action of microbicidal molecules in phagolysosomes.
Signals from various receptors, including pattern recognition receptors, opsonin receptors, receptors for cytokines, and CD40, function cooperatively to activate phagocytes to kill ingested microbes.
Signals from various receptors, including pattern recognition receptors, opsonin receptors, receptors for cytokines, and CD40, function cooperatively to activate phagocytes to kill ingested microbes.
Fusion of phagocytic vacuoles with lysosomes results in the formation of phagolysosomes, where most of the microbicidal mechanisms are concentrated.
Fusion of phagocytic vacuoles with lysosomes results in the formation of phagolysosomes, where most of the microbicidal mechanisms are concentrated.
Activated neutrophils and macrophages primarily use reactive oxygen species (ROS) to kill ingested microbes.
Activated neutrophils and macrophages primarily use reactive oxygen species (ROS) to kill ingested microbes.
