10 Questions
Which of the following cells synthesizes IL-6 in response to PAMPs and DAMPs?
Mononuclear phagocytes
What is the function of IL-6 in the regulation of the immune system and the nervous system?
Promotes the differentiation of IL-17–producing helper T cells
Which protein does IL-6 bind to on target cells?
80 kDa IL-6 receptor (IL-6R)
What is the role of gp130 in IL-6 signaling?
It dimerizes and initiates intracellular signaling
Where is IL-6R predominantly expressed in the body?
Hepatocytes and some leukocytes
Phagocytosed microbes are destroyed and peptides are generated from microbial proteins for adaptive immune responses.
True
Activated neutrophils and macrophages kill phagocytosed microbes by the action of microbicidal molecules in phagolysosomes.
True
Signals from various receptors, including pattern recognition receptors, opsonin receptors, receptors for cytokines, and CD40, function cooperatively to activate phagocytes to kill ingested microbes.
True
Fusion of phagocytic vacuoles with lysosomes results in the formation of phagolysosomes, where most of the microbicidal mechanisms are concentrated.
True
Activated neutrophils and macrophages primarily use reactive oxygen species (ROS) to kill ingested microbes.
False
Test your knowledge of the cytokine IL-6 and its role in acute inflammatory responses with this quiz. Explore its local and systemic effects, its role in promoting helper T cell differentiation, and its synthesis by various cells in response to stimuli.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
