IgG4-­RD Preliminary Inclusion Criteria
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Questions and Answers

Which autoantibodies are NOT considered specific in the diagnosis of IgG4-related disease?

  • Antiphospholipid antibodies
  • Antinuclear antibodies
  • Rheumatoid factor
  • Cryoglobulinemia (correct)

    • What are the characteristic radiologic findings suspicious for malignancy or infection that should be investigated further?

  • Nodular opacities
  • Pleural effusion
  • Bulky or matted lymphadenopathy (correct)
  • Lung consolidation

    • What defines rapid radiologic progression as mentioned in the text?

  • Significant worsening within a 3-4 week interval
  • Significant worsening within a 4-6 week interval (correct)
  • Significant worsening within a 1-2 week interval
  • Significant worsening within a 2-3 week interval

    • What are the long bone abnormalities consistent with Erdheim-Chester disease?

    <p>Multifocal osteosclerotic lesions with bilateral diaphyseal involvement</p> Signup and view all the answers

    What defines splenomegaly in the context mentioned?

    <p>&gt;14 cm</p> Signup and view all the answers

    What provides strong evidence against IgG4-related disease?

    <p>Fibrinoid necrosis within blood vessel walls</p> Signup and view all the answers

    Which disease is an exclusion criteria for IgG4-related disease?

    <p>Castleman’s disease</p> Signup and view all the answers

    What are the specific markers consistent with inflammatory myofibroblastic tumor?

    <p>Anaplastic lymphoma kinase 1 (ALK-1) positivity</p> Signup and view all the answers

    Which feature is highly atypical of IgG4-related disease?

    <p>Granuloma formation</p> Signup and view all the answers

    What are the diseases that can be part of the IgG4-RD spectrum?

    <p>Hashimoto thyroiditis and Sjögren's syndrome</p> Signup and view all the answers

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