أسئلة الخامسة جراحة رابعة دمياط (أطفال)

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Questions and Answers

Which of the following electrolyte imbalances is commonly associated with hypertrophic pyloric stenosis?

  • Hyponatremic hyperkalemic metabolic acidosis
  • Hypochloremic hypokalemic metabolic alkalosis (correct)
  • Hyperchloremic metabolic acidosis
  • Hypernatremic metabolic acidosis

A 3-week-old male infant presents with non-bilious projectile vomiting after each feeding. Which of the following is the MOST likely diagnosis?

  • Intussusception
  • Gastroesophageal reflux disease (GERD)
  • Hypertrophic pyloric stenosis (correct)
  • Duodenal atresia

During the physical examination of an infant with suspected pyloric stenosis, what palpable finding is MOST indicative of this condition?

  • Palpable 'olive' mass in the epigastrium (correct)
  • Distended bladder
  • Enlarged liver
  • Diffuse abdominal tenderness

What seasonal variation is most associated with Hypertrophic Pyloric Stenosis?

<p>Peak in Spring (C)</p> Signup and view all the answers

What is the MOST appropriate initial step in managing an infant diagnosed with hypertrophic pyloric stenosis?

<p>Fluid resuscitation to correct dehydration and electrolyte imbalances (A)</p> Signup and view all the answers

Which of the following radiological findings is MOST indicative of hypertrophic pyloric stenosis on an upper gastrointestinal contrast study?

<p>'String sign' due to a narrow pyloric channel (B)</p> Signup and view all the answers

What is the primary goal of the Ramstedt pyloromyotomy procedure in the treatment of hypertrophic pyloric stenosis?

<p>Widening the pyloric channel by incising the muscle (C)</p> Signup and view all the answers

What is the expected male to female ratio of infants affected by Hypertrophic Pyloric Stenosis?

<p>4:1 (B)</p> Signup and view all the answers

Besides dehydration, which of the following is a known complication of Hypertrophic Pyloric Stenosis?

<p>Gastritis &amp; Reflux Esophagitis (C)</p> Signup and view all the answers

Apart from genetic and familial factors, what is an environmental etiological factor that can cause Hypertrophic Pyloric Stenosis?

<p>Erythromycin or azithromycin exposure (A)</p> Signup and view all the answers

An infant presents with non-bilious projectile vomiting. Lab results show hypochloremic, hypokalemic metabolic alkalosis. Which of the following best explains the underlying pathophysiology leading to these electrolyte imbalances?

<p>Loss of gastric acid (HCl) and potassium in vomitus. (C)</p> Signup and view all the answers

After initial resuscitation, an infant with pyloric stenosis is scheduled for a Ramstedt pyloromyotomy. What is the MOST important consideration for the surgeon during this procedure?

<p>Ensuring complete division of the pyloric muscle fibers. (D)</p> Signup and view all the answers

What would be the MOST appropriate initial fluid management strategy for an infant presenting with signs of dehydration due to hypertrophic pyloric stenosis?

<p>10-20 mL/kg bolus of normal saline. (C)</p> Signup and view all the answers

Which finding on an abdominal ultrasound is MOST consistent with the diagnosis of hypertrophic pyloric stenosis?

<p>Pyloric muscle thickness &gt; 4 mm and pyloric length &gt; 16 mm. (C)</p> Signup and view all the answers

An infant with pyloric stenosis experiences persistent vomiting despite appropriate fluid resuscitation. Which of the following acid-base imbalances is MOST likely to develop?

<p>Metabolic alkalosis with paradoxical aciduria. (D)</p> Signup and view all the answers

During the surgical correction of pyloric stenosis, what is the PRIMARY reason for carefully avoiding injury to the mucosa?

<p>To prevent leakage of gastric contents into the peritoneum. (C)</p> Signup and view all the answers

Besides hypertrophic pyloric stenosis, what other medical condition would be on the differential for bilious vomiting?

<p>Duodenal stenosis (B)</p> Signup and view all the answers

What is the aim of Potassium administration in the treatment of Hypertrophic Pyloric Stenosis?

<p>Correct hypokalemia (A)</p> Signup and view all the answers

Besides the genetic or familial etiology, what other cause has been linked to Hypertrophic Pyloric Stenosis?

<p>Erythromycin exposure (D)</p> Signup and view all the answers

Gastric peristaltic waves that move from the left costal margin to the pylorus can be observed for infants with Hypertrophic Pyloric Stenosis. What does this observation suggest?

<p>The infant has a bowel obstruction. (B)</p> Signup and view all the answers

In the context of hypertrophic pyloric stenosis, what is the rationale behind administering intravenous fluids containing potassium chloride after initial resuscitation with normal saline?

<p>To directly address the hypokalemia resulting from renal compensation and urinary potassium losses. (C)</p> Signup and view all the answers

An infant with hypertrophic pyloric stenosis presents with a palpable 'olive' mass and visible peristaltic waves. Which statement BEST integrates this clinical presentation with the underlying pathophysiology?

<p>Gastric peristaltic waves are a compensatory mechanism to overcome pyloric obstruction, while the 'olive' mass confirms the pyloric hypertrophy. (B)</p> Signup and view all the answers

What is the MOST critical difference in the presentation of emesis between pyloric stenosis and other causes of vomiting in infants, and how does this difference inform diagnostic considerations?

<p>Pyloric stenosis presents characteristically with non-bilious projectile vomiting which differentiates it from conditions like GERD. (C)</p> Signup and view all the answers

After successful surgical correction of pyloric stenosis via pyloromyotomy, an infant continues to exhibit forceful vomiting. What is the MOST likely reason for the persistence of this symptom?

<p>Incomplete division of the pyloric muscle during the initial surgery. (C)</p> Signup and view all the answers

An infant diagnosed with hypertrophic pyloric stenosis has undergone initial resuscitation. What is the clinical rationale for delaying surgical intervention until the infant demonstrates adequate urine output and normalized electrolyte levels?

<p>Correction of dehydration and electrolyte imbalances minimizes the risk of anesthesia-related complications and optimizes surgical outcomes. (B)</p> Signup and view all the answers

Which of the following statements BEST explains the increased risk of hypertrophic pyloric stenosis in first-born male infants, considering genetic and epigenetic factors?

<p>Specific genes involved in pyloric development may undergo epigenetic modifications affecting first-born males. (A)</p> Signup and view all the answers

In managing an infant with hypertrophic pyloric stenosis-induced metabolic alkalosis, what compensatory mechanisms should the clinician anticipate, and how do these mechanisms influence management strategies?

<p>The infant compensates via decreased respiratory rate, leading to an increase in PaCO2, which should be considered while planning ventilation strategies. (C)</p> Signup and view all the answers

While assessing an infant with suspected pyloric stenosis using abdominal ultrasound, the sonographer struggles to visualize the pylorus adequately. Which of the following maneuvers is MOST likely to improve visualization and diagnostic accuracy?

<p>Applying gentle, sustained pressure with the transducer to displace bowel gas. (C)</p> Signup and view all the answers

An infant with confirmed hypertrophic pyloric stenosis is being prepared for Ramstedt pyloromyotomy. Which of the following pre-operative findings would MOST strongly suggest the presence of a concurrent metabolic derangement that requires further investigation beyond typical pyloric stenosis-related electrolyte abnormalities?

<p>Elevated blood urea nitrogen (BUN) and creatinine levels. (B)</p> Signup and view all the answers

Following a Ramstedt pyloromyotomy, an infant exhibits persistent irritability and feeding intolerance, alongside signs of abdominal distension. What potential complication should be HIGHEST on the list of differential diagnoses?

<p>Duodenal hematoma or perforation. (C)</p> Signup and view all the answers

Flashcards

Hypertrophic Pyloric Stenosis

A condition marked by the thickening of the pylorus muscle, leading to gastric outlet obstruction.

Non-bilious Projectile Vomiting

Vomiting that's forceful but doesn't contain bile, often occurring 2-4 weeks after birth.

Hypocholoraemic Hypokalaemic Alkalosis

A condition where the body's acid-base balance is disturbed due to loss of stomach acid.

Gastric Peristaltic Waves

Gastric peristaltic waves are visual movements across the abdomen indicating the stomach is trying to force contents through a narrowed pylorus.

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Palpable Pyloric Mass

Feeling a pyloric tumor or 'olive mass' upon abdominal palpation.

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Pyloric Stenosis Ultrasound Criteria

Identifying hypertrophic pyloric stenosis from the muscle being >4 mm thick or the pylorus >16 mm long.

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String Sign

A narrow pyloric channel seen during barium studies of the upper gastrointestinal tract.

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Beak Sign

A bulge in the distal antrum with a barium streak towards canal.

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Pyloric Stenosis Treatment

Mainstay of therapy involves stabilizing the patient and correcting electrolyte imbalances before surgery.

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Pyloromyotomy

A surgical incision of the pyloric muscle to relieve the obstruction.

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Hypertrophic Pyloric Stenosis (HPS)

A condition characterized by hypertrophy of the pylorus' circular muscle layers, obstructing the gastric outlet.

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Visible Gastric Peristalsis

Gastric peristaltic waves seen moving across the abdomen from left to right indicating the stomach is trying to force contents through a narrowed pylorus.

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Hypochloremic, hypokalemic metabolic alkalosis

This occurs because of persistent vomiting and loss of stomach acid.

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Infant with pyloric stenosis

This occurs after vomiting, because the infant is starved and then acts starved and feeds again.

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Arterial Blood Gas (ABG) abnormalities in HPS

Measure of blood acidity & bicarbonate levels; indicates metabolic disturbances.

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Beak Sign on Upper GI Series

A bulge in the distal antrum with a thin barium streak, indicating a narrowed pyloric channel.

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Ramstedt Pyloromyotomy

A surgical procedure where the pyloric muscle is incised to relieve gastric outlet obstruction.

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Anatomic causes

Antral web, foregut duplication cyst and duodenal stenosis

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Levels as markers of adequate resuscitation

Serum CO2 (<30 mmol/L), Chloride (>100 mmol/L), Potassium (4.5-6.5 mmol/L)

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HPS Seasonal Variation

Seasonal variation with peak emesis in spring

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HPS and Constipation

May show infrequent, firm stools.

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HPS Vomiting type

Regurgitation and progressive feeding intolerance due to hypertrophy.

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Typical onset age

Appear 2-4 weeks after birth

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HPS General Signs

Dehydration, sunken eyes, dry mucus membranes.

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HPS vs Ethnic Origin

Seen more in whites

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HPS and Firstborn boys

Increased risk in firstborn boys

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Environmental Etiology

Erythromycin exposure or transpyloric feeding in premature babies.

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Study Notes

  • Hypertrophic pyloric stenosis is a condition marked by hypertrophy of the pylorus' circular muscle layers, causing constriction and obstruction of the gastric outlet.
  • Described by Hirschsprung in 1888.
  • Costs 5 LE.

Incidence

  • Occurs in 1-4 per 1000 live births.
  • Male to female ratio of 4:1.
  • Increased risk in firstborn boys.
  • Symptoms often show a seasonal peak in the spring.
  • Leading surgical cause of emesis in infancy.

Etiology

  • Can be idiopathic.
  • Genetic factors are rarely autosomal dominant.
  • May be familial.
  • Ethnic origin is more common in whites, particularly Caucasians.
  • Environmental factors include erythromycin or azithromycin exposure.
  • Transpyloric feeding of premature babies is also a risk factor.

Pathophysiology

  • Hypertrophied muscles lead to gastric outlet obstruction (GOO).
  • GOO results in non-bilious projectile vomiting.
  • Gastric fluid loss is also typical.
  • Results in hypochloremic hypokalemic alkalosis.
  • Leads to paradoxical aciduria.

Symptoms

  • Typically appears 2-4 weeks after birth.

Manifestation

  • Occasional regurgitation that becomes more frequent and forceful over several days.
  • Vomiting is non-bilious.
  • Shortly after vomiting, the infant acts starved and will feed vigorously.
  • The infant experiences constipation with infrequent and firm stools.
  • Progressive feeding intolerance and weight loss leading to failure to thrive.

Signs

  • Dehydration.
  • General signs include dry mucous membranes.
  • Oliguria.
  • Sunken eyes.
  • Poor skin turgor.
  • Jaundice in 2% of cases from starvation.
  • Depressed fontanelles.
  • Local signs include gastric peristaltic waves moving from left costal margin to the pylorus.
  • Palpation reveals a pyloric tumor or olive mass in over 90% of cases.

Complications

  • Dehydration.
  • Hypokalemic hypochloremic metabolic alkalosis with paradoxical aciduria.
  • Starvation.
  • Gastritis and reflux esophagitis.
  • Aspiration pneumonia.

Investigations

Laboratory

  • Hypochloremic hypokalemic metabolic alkalosis.
  • Paradoxical aciduria.
  • Hyperbilirubinemia.
  • Low serum levels of potassium and chloride.
  • Increased blood pH and high blood bicarbonate level.

Radiological

  • Abdominal ultrasound is the most sensitive and specific test.
  • Muscle thickness greater than 4 mm or length of pylorus greater than 16 mm.
  • String sign indicates a narrow pyloric channel.
  • Bulge in the distal antrum with streak of barium pointing towards the pyloric channel.
  • Beak sign is a bulge in the distal antrum with a barium streak pointing towards the pyloric canal.
  • Barium may outline crowded mucosal folds as parallel lines.

Differential Diagnosis

Medical Causes

  • Overfeeding.
  • GERD.
  • Gastroenteritis.
  • Pylorospasm.
  • Increased intracranial pressure.
  • Metabolic disorders like adrenal insufficiency.

Anatomic causes

  • Antral web.
  • Foregut duplication cyst.
  • Duodenal stenosis.
  • Gastric tumors.
  • Tumors causing extrinsic gastric compression.

Treatment

  • Mainstay therapy is resuscitation.
  • Followed by pyloromyotomy.

Preoperative

  • Correct dehydration.
  • Correct hypokalemic hyperchloremic alkalosis.
  • Give a 10-20 mL/kg bolus of normal saline initially if electrolyte values are abnormal.
  • Follow with D5/½NS containing 20-30 mEq/L of potassium chloride at 1.25-2 times the maintenance rate.
  • Monitor serum carbon dioxide to be less than 30 mmol/L.
  • Monitor chloride to be greater than 100 mmol/L.
  • Monitor potassium to be between 4.5-6.5 mmol/L.

Operative

  • Ramstedt pyloromyotomy.
  • Approaches include a right upper quadrant transverse skin incision.
  • Or a circumumbilical skin incision known as "Bianchi".
  • Or via a laparoscopic approach.
  • Pylorus is incised along its entire length.
  • Spread widely, exposing but not breaching the underlying mucosa.

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