Podcast
Questions and Answers
What can an embolus that leaves the left ventricle potentially cause?
What can an embolus that leaves the left ventricle potentially cause?
- Deep vein thrombosis
- Pulmonary embolism
- Atherosclerosis
- Ischemic stroke (correct)
Peripheral edema is a result of arterial thrombosis.
Peripheral edema is a result of arterial thrombosis.
False (B)
What is athero-sclerosis primarily characterized by?
What is athero-sclerosis primarily characterized by?
formation of plaque and hardening of arteries
An embolus that leaves the right ventricle can lead to _______.
An embolus that leaves the right ventricle can lead to _______.
Match the terms to their correct definitions:
Match the terms to their correct definitions:
Which of the following is a key advantage of allogenic bone marrow transplant over autologous bone marrow transplant?
Which of the following is a key advantage of allogenic bone marrow transplant over autologous bone marrow transplant?
Aplastic anemia leads to increased production of red blood cells.
Aplastic anemia leads to increased production of red blood cells.
What hormone do kidneys produce that stimulates red blood cell production?
What hormone do kidneys produce that stimulates red blood cell production?
Iron deficiency leads to _____ color, microcytic red blood cells, and low MCV.
Iron deficiency leads to _____ color, microcytic red blood cells, and low MCV.
Which of the following is NOT a cause of aplastic anemia?
Which of the following is NOT a cause of aplastic anemia?
Carbon dioxide is primarily transported in the blood in the form of bicarbonate ion.
Carbon dioxide is primarily transported in the blood in the form of bicarbonate ion.
Pernicious anemia is caused by a lack of _____ factor.
Pernicious anemia is caused by a lack of _____ factor.
Match the following anemias with their causes:
Match the following anemias with their causes:
What is the primary gene implicated in inhibiting apoptotic cell death in CML?
What is the primary gene implicated in inhibiting apoptotic cell death in CML?
CML cells are immature compared to AML cells.
CML cells are immature compared to AML cells.
Name one symptom commonly associated with Chronic Myeloid Leukemia.
Name one symptom commonly associated with Chronic Myeloid Leukemia.
Multiple Myeloma mainly affects __________ tissue.
Multiple Myeloma mainly affects __________ tissue.
Which treatment is NOT considered effective for Multiple Myeloma?
Which treatment is NOT considered effective for Multiple Myeloma?
Match the following diseases with their key features:
Match the following diseases with their key features:
Allogenic bone marrow transplantation is a treatment option for Chronic Myeloid Leukemia.
Allogenic bone marrow transplantation is a treatment option for Chronic Myeloid Leukemia.
What type of cells does Hairy Cell Leukemia primarily affect?
What type of cells does Hairy Cell Leukemia primarily affect?
The excessive production of __________ antibodies is a hallmark of Multiple Myeloma.
The excessive production of __________ antibodies is a hallmark of Multiple Myeloma.
Which of the following is a common symptom of Hairy Cell Leukemia?
Which of the following is a common symptom of Hairy Cell Leukemia?
What percentage of acute lymphoblastic leukemia (ALL) cases are due to malignant transformation of T-cells?
What percentage of acute lymphoblastic leukemia (ALL) cases are due to malignant transformation of T-cells?
Acute lymphoblastic leukemia primarily affects adults, with children being less commonly diagnosed.
Acute lymphoblastic leukemia primarily affects adults, with children being less commonly diagnosed.
Name two common symptoms of acute lymphoblastic leukemia (ALL).
Name two common symptoms of acute lymphoblastic leukemia (ALL).
The abnormality associated with Chronic Myeloid Leukemia (CML) is found on the __________ chromosome.
The abnormality associated with Chronic Myeloid Leukemia (CML) is found on the __________ chromosome.
Match the types of leukemia with their common characteristics:
Match the types of leukemia with their common characteristics:
Which treatment options are indicated for acute lymphoblastic leukemia (ALL)?
Which treatment options are indicated for acute lymphoblastic leukemia (ALL)?
The prognosis for children diagnosed with acute lymphoblastic leukemia (ALL) is poor, with a 5-year prognosis of only 30 to 50%.
The prognosis for children diagnosed with acute lymphoblastic leukemia (ALL) is poor, with a 5-year prognosis of only 30 to 50%.
Chronic Myeloid Leukemia (CML) primarily affects __________ cells.
Chronic Myeloid Leukemia (CML) primarily affects __________ cells.
Hemophilia is an acquired coagulation disorder.
Hemophilia is an acquired coagulation disorder.
What type of hypersensitivity is primarily mediated by IgE antibodies?
What type of hypersensitivity is primarily mediated by IgE antibodies?
Which of the following is NOT a compensation mechanism for reduced oxygen-carrying capacity?
Which of the following is NOT a compensation mechanism for reduced oxygen-carrying capacity?
Type II hypersensitivity reactions occur within hours after exposure to the antigen.
Type II hypersensitivity reactions occur within hours after exposure to the antigen.
What is the primary deficiency in Hemophilia A?
What is the primary deficiency in Hemophilia A?
Vitamin K deficiency in newborns can lead to ______, bleeding from the umbilicus, and hematuria.
Vitamin K deficiency in newborns can lead to ______, bleeding from the umbilicus, and hematuria.
Name one example of a Type III hypersensitivity reaction.
Name one example of a Type III hypersensitivity reaction.
The primary cells involved in Type IV hypersensitivity are ______.
The primary cells involved in Type IV hypersensitivity are ______.
Match the following conditions with their corresponding lab results.
Match the following conditions with their corresponding lab results.
Match the following hypersensitivity types with their characteristics:
Match the following hypersensitivity types with their characteristics:
Which of the following conditions is an example of a Type IV hypersensitivity reaction?
Which of the following conditions is an example of a Type IV hypersensitivity reaction?
Type III hypersensitivity reactions involve the activation of complement by an antigen-antibody complex.
Type III hypersensitivity reactions involve the activation of complement by an antigen-antibody complex.
What type of cells are transformed in the majority of Acute Lymphoblastic Leukemia (ALL) cases?
What type of cells are transformed in the majority of Acute Lymphoblastic Leukemia (ALL) cases?
The allergic reaction in Type I hypersensitivity typically occurs within ______ minutes after exposure.
The allergic reaction in Type I hypersensitivity typically occurs within ______ minutes after exposure.
Which of the following is a common feature of cytotoxic hypersensitivity (Type II)?
Which of the following is a common feature of cytotoxic hypersensitivity (Type II)?
Flashcards
Acute Lymphoblastic Leukemia (ALL)
Acute Lymphoblastic Leukemia (ALL)
A type of cancer affecting immature lymphocytes, primarily in children.
Lymphoblastic Transformation
Lymphoblastic Transformation
Development of abnormal T-cells into malignant lymphoblasts in ALL.
Clinical Manifestations of ALL
Clinical Manifestations of ALL
Symptoms include bone pain, fever, and fatigue among others.
Peak Incidence of ALL
Peak Incidence of ALL
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Treatment of ALL
Treatment of ALL
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Chronic Myeloid Leukemia (CML)
Chronic Myeloid Leukemia (CML)
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Philadelphia Chromosome
Philadelphia Chromosome
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Prognosis of ALL
Prognosis of ALL
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Allogenic Bone Marrow Transplant
Allogenic Bone Marrow Transplant
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Autologous Bone Marrow Transplant
Autologous Bone Marrow Transplant
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Transfusion Reactions
Transfusion Reactions
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Iron Deficiency Anemia Symptoms
Iron Deficiency Anemia Symptoms
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Kidneys and Erythropoietin
Kidneys and Erythropoietin
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Aplastic Anemia Causes
Aplastic Anemia Causes
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Pernicious Anemia
Pernicious Anemia
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Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency
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Type I hypersensitivity
Type I hypersensitivity
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Mast cells
Mast cells
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Type II hypersensitivity
Type II hypersensitivity
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Lysis
Lysis
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Type III hypersensitivity
Type III hypersensitivity
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IgG antibodies
IgG antibodies
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Type IV hypersensitivity
Type IV hypersensitivity
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Sensitized T-cells
Sensitized T-cells
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Malignant transformation of B-cells
Malignant transformation of B-cells
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Circulatory System Functions
Circulatory System Functions
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Ischemia and Hypoxia
Ischemia and Hypoxia
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Hemophilia
Hemophilia
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Vitamin K Deficiency Symptoms
Vitamin K Deficiency Symptoms
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PT and INR
PT and INR
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Embolus
Embolus
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Ischemic Stroke
Ischemic Stroke
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Pulmonary Embolism
Pulmonary Embolism
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Atherosclerosis
Atherosclerosis
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DVT
DVT
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BCR-ABL gene
BCR-ABL gene
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Multiple Myeloma
Multiple Myeloma
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Bence-Jones protein
Bence-Jones protein
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Honeycomb bone appearance
Honeycomb bone appearance
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Hairy Cell Leukemia
Hairy Cell Leukemia
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Clinical Manifestations of Hairy Cell Leukemia
Clinical Manifestations of Hairy Cell Leukemia
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Treatment for Hairy Cell Leukemia
Treatment for Hairy Cell Leukemia
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Study Notes
Hypersensitivity Types
- Four types of hypersensitivity exist: Type I, Type II, Type III, and Type IV.
- Type I, also known as immediate hypersensitivity, is an allergic response to antigens or allergens.
- IgE antibodies bind to mast cells, triggering the release of histamine and other inflammatory mediators.
- Symptoms typically appear within 15-30 minutes.
- Examples include allergic reactions, transfusion reactions, and some autoimmune diseases.
- Type II hypersensitivity, also known as cytotoxic hypersensitivity, involves antibodies targeting antigens on cell surfaces, leading to cell lysis.
- IgM and IgG antibodies may be involved, often with complement activation.
- This type of hypersensitivity also usually occurs within 15-30 minutes.
- Examples include transfusion reactions and some autoimmune diseases.
- Type III hypersensitivity, or immune complex hypersensitivity, involves the deposition of antigen-antibody complexes in tissues, triggering complement activation and inflammation.
- This occurs typically around 6 hours after exposure.
- Examples include glomerulonephritis and lupus.
- Type IV hypersensitivity, or cell-mediated hypersensitivity, is not antibody-mediated; instead, sensitized T cells react with altered or foreign cells and cause inflammation.
- This response typically appears 24-48 hours post-exposure.
- Examples include contact dermatitis and some autoimmune diseases.
Additional Information
- Chronic Myeloid Leukemia (CML) is a type of blood cancer originating from myeloid cells, characterized by a specific chromosome abnormality (Ph chromosome).
- CML is more common in older adults.
- Acute Lymphoblastic Leukemia (ALL) is a cancer of the blood-forming cells, affecting immature cells (lymphoblasts) and usually occurring in children.
- Multiple Myeloma is a cancer of plasma cells in the bone marrow.
- Hairy Cell Leukemia is a rare adult leukemia in which the cancerous blood cells look unusual under a microscope.
- In autoimmune diseases, the immune system attacks its own cells, leading to inflammation and dysfunction in affected organs.
- Hypersensitivity reactions are exaggerated immune responses that can cause harm to the body.
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