Week 2 Study Guide

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Questions and Answers

What can an embolus that leaves the left ventricle potentially cause?

  • Deep vein thrombosis
  • Pulmonary embolism
  • Atherosclerosis
  • Ischemic stroke (correct)

Peripheral edema is a result of arterial thrombosis.

False (B)

What is athero-sclerosis primarily characterized by?

formation of plaque and hardening of arteries

An embolus that leaves the right ventricle can lead to _______.

<p>pulmonary embolism</p> Signup and view all the answers

Match the terms to their correct definitions:

<p>Varicose veins = Superficial, darkened, raised veins DVT = Deep vein thrombosis affecting peripheral limbs Atherosclerosis = Formation of plaque in arteries Peripheral edema = Fluid accumulation due to venous obstruction</p> Signup and view all the answers

Which of the following is a key advantage of allogenic bone marrow transplant over autologous bone marrow transplant?

<p>It has a lower risk of malignant cells being present. (C)</p> Signup and view all the answers

Aplastic anemia leads to increased production of red blood cells.

<p>False (B)</p> Signup and view all the answers

What hormone do kidneys produce that stimulates red blood cell production?

<p>erythropoietin</p> Signup and view all the answers

Iron deficiency leads to _____ color, microcytic red blood cells, and low MCV.

<p>pale</p> Signup and view all the answers

Which of the following is NOT a cause of aplastic anemia?

<p>Nutritional deficiency (A)</p> Signup and view all the answers

Carbon dioxide is primarily transported in the blood in the form of bicarbonate ion.

<p>True (A)</p> Signup and view all the answers

Pernicious anemia is caused by a lack of _____ factor.

<p>intrinsic</p> Signup and view all the answers

Match the following anemias with their causes:

<p>Aplastic Anemia = Reduction in hematopoietic tissue Iron Deficiency Anemia = Lack of iron Pernicious Anemia = Lack of intrinsic factor Glucose-6-Phosphate Dehydrogenase Deficiency Anemia = Exposure to certain drugs</p> Signup and view all the answers

What is the primary gene implicated in inhibiting apoptotic cell death in CML?

<p>BCR-ABL (C)</p> Signup and view all the answers

CML cells are immature compared to AML cells.

<p>False (B)</p> Signup and view all the answers

Name one symptom commonly associated with Chronic Myeloid Leukemia.

<p>Fatigue</p> Signup and view all the answers

Multiple Myeloma mainly affects __________ tissue.

<p>bone</p> Signup and view all the answers

Which treatment is NOT considered effective for Multiple Myeloma?

<p>Chemotherapy (D)</p> Signup and view all the answers

Match the following diseases with their key features:

<p>CML = High granulocyte count and splenomegaly Multiple Myeloma = Malignant disorder of plasma cells Hairy Cell Leukemia = Presence of hairy appearing B-cells</p> Signup and view all the answers

Allogenic bone marrow transplantation is a treatment option for Chronic Myeloid Leukemia.

<p>True (A)</p> Signup and view all the answers

What type of cells does Hairy Cell Leukemia primarily affect?

<p>B-cells</p> Signup and view all the answers

The excessive production of __________ antibodies is a hallmark of Multiple Myeloma.

<p>monoclonal</p> Signup and view all the answers

Which of the following is a common symptom of Hairy Cell Leukemia?

<p>Enlarged spleen (C)</p> Signup and view all the answers

What percentage of acute lymphoblastic leukemia (ALL) cases are due to malignant transformation of T-cells?

<p>20% (C)</p> Signup and view all the answers

Acute lymphoblastic leukemia primarily affects adults, with children being less commonly diagnosed.

<p>False (B)</p> Signup and view all the answers

Name two common symptoms of acute lymphoblastic leukemia (ALL).

<p>Bone pain, fever</p> Signup and view all the answers

The abnormality associated with Chronic Myeloid Leukemia (CML) is found on the __________ chromosome.

<p>Philadelphia</p> Signup and view all the answers

Match the types of leukemia with their common characteristics:

<p>Acute Lymphoblastic Leukemia = Primarily affects children and exhibits abrupt onset Chronic Myeloid Leukemia = More prevalent in adults, especially men, and involves the Philadelphia chromosome</p> Signup and view all the answers

Which treatment options are indicated for acute lymphoblastic leukemia (ALL)?

<p>Chemotherapy and stem cell transplantation (C)</p> Signup and view all the answers

The prognosis for children diagnosed with acute lymphoblastic leukemia (ALL) is poor, with a 5-year prognosis of only 30 to 50%.

<p>False (B)</p> Signup and view all the answers

Chronic Myeloid Leukemia (CML) primarily affects __________ cells.

<p>neutrophils</p> Signup and view all the answers

Hemophilia is an acquired coagulation disorder.

<p>False (B)</p> Signup and view all the answers

What type of hypersensitivity is primarily mediated by IgE antibodies?

<p>Type I hypersensitivity (C)</p> Signup and view all the answers

Which of the following is NOT a compensation mechanism for reduced oxygen-carrying capacity?

<p>Decreased cardiac output (D)</p> Signup and view all the answers

Type II hypersensitivity reactions occur within hours after exposure to the antigen.

<p>False (B)</p> Signup and view all the answers

What is the primary deficiency in Hemophilia A?

<p>Factor VIII</p> Signup and view all the answers

Vitamin K deficiency in newborns can lead to ______, bleeding from the umbilicus, and hematuria.

<p>melena</p> Signup and view all the answers

Name one example of a Type III hypersensitivity reaction.

<p>glomerulonephritis</p> Signup and view all the answers

The primary cells involved in Type IV hypersensitivity are ______.

<p>T-cells</p> Signup and view all the answers

Match the following conditions with their corresponding lab results.

<p>Hemophilia = Prolonged bleeding time, prolonged aPTT, normal platelet count Vitamin K deficiency = Normal bleeding time, normal platelet count, increased PT and INR</p> Signup and view all the answers

Match the following hypersensitivity types with their characteristics:

<p>Type I = Mediated by IgE antibodies Type II = Cytotoxic reactions leading to cell lysis Type III = Mediated by immune complex deposition Type IV = Mediated by T-cells</p> Signup and view all the answers

Which of the following conditions is an example of a Type IV hypersensitivity reaction?

<p>Contact dermatitis (B)</p> Signup and view all the answers

Type III hypersensitivity reactions involve the activation of complement by an antigen-antibody complex.

<p>True (A)</p> Signup and view all the answers

What type of cells are transformed in the majority of Acute Lymphoblastic Leukemia (ALL) cases?

<p>B-cells</p> Signup and view all the answers

The allergic reaction in Type I hypersensitivity typically occurs within ______ minutes after exposure.

<p>15 to 30</p> Signup and view all the answers

Which of the following is a common feature of cytotoxic hypersensitivity (Type II)?

<p>Lysis of target cells (B)</p> Signup and view all the answers

Flashcards

Acute Lymphoblastic Leukemia (ALL)

A type of cancer affecting immature lymphocytes, primarily in children.

Lymphoblastic Transformation

Development of abnormal T-cells into malignant lymphoblasts in ALL.

Clinical Manifestations of ALL

Symptoms include bone pain, fever, and fatigue among others.

Peak Incidence of ALL

Occurs mainly in children, ages 3 to 7, with a second peak in middle age.

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Treatment of ALL

Typically involves chemotherapy and possibly stem cell transplantation.

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Chronic Myeloid Leukemia (CML)

A cancer of the blood that affects older adults more, primarily due to neutrophil proliferation.

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Philadelphia Chromosome

Abnormal chromosome found in CML, results from translocation that creates BCR-ABL fusion gene.

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Prognosis of ALL

85% survival rate in children and 30-50% in adults over 5 years.

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Allogenic Bone Marrow Transplant

Transplantation of bone marrow from a compatible donor to a patient.

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Autologous Bone Marrow Transplant

A transplant using the patient's own harvested bone marrow after cancer treatment.

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Transfusion Reactions

Destruction of red blood cells due to recipient antibodies during transfusion.

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Iron Deficiency Anemia Symptoms

Characterized by low MCHC, MCH, and MCV values in blood tests.

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Kidneys and Erythropoietin

Kidneys produce erythropoietin to stimulate red blood cell production.

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Aplastic Anemia Causes

Reduction in hematopoietic tissue leading to pancytopenia due to various injuries.

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Pernicious Anemia

Anemia caused by a lack of intrinsic factor needed for vitamin B12 absorption.

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Glucose-6-Phosphate Dehydrogenase Deficiency

Anemia occurs when G6PD deficiency is triggered by certain drugs.

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Type I hypersensitivity

Immediate hypersensitivity reaction mediated by IgE antibodies.

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Mast cells

Cells that release chemicals like histamine during hypersensitivity reactions.

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Type II hypersensitivity

Cytotoxic hypersensitivity involving IgM and IgG antibodies causing cell lysis.

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Lysis

The destruction or disintegration of cells.

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Type III hypersensitivity

Immune complex hypersensitivity causing tissue inflammation.

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IgG antibodies

Immunoglobulins that mediate Type III hypersensitivity and are key in immune response.

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Type IV hypersensitivity

Delayed hypersensitivity mediated by T-cells, not involving antibodies.

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Sensitized T-cells

T-cells that have been exposed to antigens and cause inflammation.

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Malignant transformation of B-cells

The conversion of normal B-cells into cancerous cells in ALL.

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Circulatory System Functions

Transports gases and removes metabolic wastes from capillaries.

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Ischemia and Hypoxia

Conditions resulting from disruption in the circulatory system.

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Hemophilia

Inherited disorder causing prolonged bleeding due to clotting factor deficiencies.

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Vitamin K Deficiency Symptoms

Melena, bleeding from umbilicus, and hematuria in newborns.

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PT and INR

Measures used to determine if blood is clotting normally.

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Embolus

A clot that has broken free and floats in the circulatory system.

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Ischemic Stroke

A stroke caused by an embolus that leaves the left ventricle.

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Pulmonary Embolism

An embolus that leaves the right ventricle causing blockage in the lungs.

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Atherosclerosis

Formation of plaque leading to hardening of arteries due to lipid accumulation.

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DVT

Deep vein thrombosis, a clot restricting blood flow in the deep veins of limbs.

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BCR-ABL gene

A gene fusion responsible for chronic myeloid leukemia (CML) that inhibits apoptosis.

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Multiple Myeloma

A malignant disorder of plasma cells, typically affects bones and occurs in adults over 40.

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Bence-Jones protein

A protein produced by malignant plasma cells that can harm kidneys.

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Honeycomb bone appearance

A damage pattern in bone due to multiple myeloma, resulting from bone substance loss.

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Hairy Cell Leukemia

A rare, chronic leukemia affecting B-cells characterized by hairy-looking cells.

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Clinical Manifestations of Hairy Cell Leukemia

Symptoms include splenomegaly, recurring infections, bleeding disorders, and anemia.

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Treatment for Hairy Cell Leukemia

Generally treated with chemotherapy protocols.

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Study Notes

Hypersensitivity Types

  • Four types of hypersensitivity exist: Type I, Type II, Type III, and Type IV.
  • Type I, also known as immediate hypersensitivity, is an allergic response to antigens or allergens.
  • IgE antibodies bind to mast cells, triggering the release of histamine and other inflammatory mediators.
  • Symptoms typically appear within 15-30 minutes.
  • Examples include allergic reactions, transfusion reactions, and some autoimmune diseases.
  • Type II hypersensitivity, also known as cytotoxic hypersensitivity, involves antibodies targeting antigens on cell surfaces, leading to cell lysis.
  • IgM and IgG antibodies may be involved, often with complement activation.
  • This type of hypersensitivity also usually occurs within 15-30 minutes.
  • Examples include transfusion reactions and some autoimmune diseases.
  • Type III hypersensitivity, or immune complex hypersensitivity, involves the deposition of antigen-antibody complexes in tissues, triggering complement activation and inflammation.
  • This occurs typically around 6 hours after exposure.
  • Examples include glomerulonephritis and lupus.
  • Type IV hypersensitivity, or cell-mediated hypersensitivity, is not antibody-mediated; instead, sensitized T cells react with altered or foreign cells and cause inflammation.
  • This response typically appears 24-48 hours post-exposure.
  • Examples include contact dermatitis and some autoimmune diseases.

Additional Information

  • Chronic Myeloid Leukemia (CML) is a type of blood cancer originating from myeloid cells, characterized by a specific chromosome abnormality (Ph chromosome).
  • CML is more common in older adults.
  • Acute Lymphoblastic Leukemia (ALL) is a cancer of the blood-forming cells, affecting immature cells (lymphoblasts) and usually occurring in children.
  • Multiple Myeloma is a cancer of plasma cells in the bone marrow.
  • Hairy Cell Leukemia is a rare adult leukemia in which the cancerous blood cells look unusual under a microscope.
  • In autoimmune diseases, the immune system attacks its own cells, leading to inflammation and dysfunction in affected organs.
  • Hypersensitivity reactions are exaggerated immune responses that can cause harm to the body.

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