Hypersensitivity Overview and Types

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Questions and Answers

Which of the following is NOT a characteristic of Type II hypersensitivities?

  • Lead to cell injury or death
  • Involve degranulation and histamine production (correct)
  • Involve antibody-dependent cellular cytotoxicity (ADCC)
  • Can be triggered by transfusion reactions

What is the primary role of surface antigens on red blood cells in relation to blood transfusions?

  • They determine the blood type and are responsible for activating the immune response during incompatible transfusions. (correct)
  • They trigger the release of histamine, leading to an allergic reaction in case of a mismatch.
  • They directly cause degranulation of mast cells, leading to inflammation and tissue damage.
  • They initiate clot formation in the blood vessels, preventing the recipient's blood from clotting properly.

Which of the following mechanisms is NOT involved in the destruction of cells in Type II hypersensitivities?

  • Antibody-dependent cellular cytotoxicity (ADCC)
  • Release of histamine by mast cells (correct)
  • Direct binding of antibodies to cell surface antigens
  • Activation of the complement system

What happens when an individual receives a transfusion of blood with incompatible antigens?

<p>The recipient's immune system produces antibodies against the incompatible antigens, leading to a transfusion reaction. (A)</p> Signup and view all the answers

What is the key difference between Type I and Type II hypersensitivities?

<p>Type I involves IgE antibodies, while Type II involves IgG or IgM antibodies. (B)</p> Signup and view all the answers

Why is it crucial to determine a patient's blood type before a blood transfusion?

<p>To ensure the blood type of the donor matches the recipient's blood type, preventing immune reactions. (D)</p> Signup and view all the answers

What is the mechanism that leads to hemolytic disease of the newborn?

<p>A mother with Rh-negative blood produces antibodies against Rh-positive antigens present on the fetus's red blood cells, potentially leading to hemolysis. (A)</p> Signup and view all the answers

Which of the following statements regarding transfusion reactions is NOT true?

<p>They are always mild and resolve without medical intervention. (C)</p> Signup and view all the answers

What is the primary reason why an Rh+ child's first pregnancy with an Rh- mother is typically uneventful?

<p>The Rh+ child's blood cells do not enter the mother's system. (C)</p> Signup and view all the answers

What is the main consequence of repeated Rh+ blood cell exposure to an Rh- mother's immune system?

<p>Production of antibodies that can cross the placenta and attack fetal Rh+ blood cells. (D)</p> Signup and view all the answers

What is the medical term for the condition affecting a baby due to Rh incompatibility?

<p>Hemolytic disease of the newborn (A), Erythroblastosis fetalis (B)</p> Signup and view all the answers

What is the primary role of the enlarged liver and spleen in a baby affected by Rh incompatibility?

<p>Filtering and removing damaged red blood cells from the circulation. (A)</p> Signup and view all the answers

What is the significance of the first Rh immune globulin shot administered to the Rh- mother during her pregnancy?

<p>It neutralizes any Rh+ blood cells that may have entered the mother's system during the pregnancy. (A)</p> Signup and view all the answers

In the context of Rh incompatibility, what is meant by 'sensitization'?

<p>The mother's immune system becoming sensitive to Rh+ blood cells. (D)</p> Signup and view all the answers

During which trimester of a pregnancy is the first Rh immune globulin shot typically given?

<p>Third trimester (D)</p> Signup and view all the answers

What is the main reason why doctors administer a series of two Rh immune globulin shots during a pregnancy?

<p>To effectively neutralize any Rh+ blood cells that enter the mother's system. (B)</p> Signup and view all the answers

What is the primary trigger for Immediate (Type I) Hypersensitivity reactions?

<p>Foreign substances called allergens (B)</p> Signup and view all the answers

Which type of hypersensitivity is associated with an immune response to antigens on cells?

<p>Type II Hypersensitivity (D)</p> Signup and view all the answers

Which of the following best defines hypersensitivity?

<p>An exaggerated immune response to a foreign substance (D)</p> Signup and view all the answers

What distinguishes Cytotoxic (Type II) Hypersensitivity from other types?

<p>It targets specific antigens present on cells (B)</p> Signup and view all the answers

What is the main mechanism behind Type I Hypersensitivity reactions?

<p>Release of histamine from mast cells upon antigen exposure (C)</p> Signup and view all the answers

Which type of hypersensitivity is linked to immune complexes that elicit an inflammatory response?

<p>Type III Hypersensitivity (C)</p> Signup and view all the answers

What does immunotherapy by desensitization aim to achieve?

<p>Reduce the immune response to allergens (B)</p> Signup and view all the answers

Which statement is true regarding Cell-mediated (Type IV) Hypersensitivity?

<p>It involves T-cells recognizing specific antigens (D)</p> Signup and view all the answers

What is the primary role of helper T cells in a normal allergic reaction?

<p>To stimulate B cells (A)</p> Signup and view all the answers

What type of antibodies are produced by plasma cells during a normal allergic reaction?

<p>IgE (B)</p> Signup and view all the answers

Which of the following statements about desensitization is accurate?

<p>It gradually reduces the sensitivity to allergens. (B)</p> Signup and view all the answers

What occurs during a second exposure to an allergen in a normal allergic reaction?

<p>Mast cells undergo degranulation. (C)</p> Signup and view all the answers

In type II hypersensitivities, what type of antibodies are mainly produced?

<p>IgG antibodies (C)</p> Signup and view all the answers

What is the effect of denatured allergens in the immune response?

<p>They prevent B cells from maturing into plasma cells. (C)</p> Signup and view all the answers

Which immune cell type binds to IgG in type II hypersensitivity?

<p>Mast cells (D)</p> Signup and view all the answers

What characterizes the symptoms alleviated by allergy treatments?

<p>They relieve but do not cure the disorder. (B)</p> Signup and view all the answers

What occurs in an Rh-negative mother carrying an Rh-positive fetus for the first time?

<p>The fetus is unharmed. (A)</p> Signup and view all the answers

What leads to hemolytic disease of the newborn with a subsequent Rh-positive pregnancy?

<p>The mother producing a strong secondary immune response. (A)</p> Signup and view all the answers

Which of the following describes the Rh factor in blood typing?

<p>An antigen present on red blood cells. (C)</p> Signup and view all the answers

What is erythroblastosis fetalis most commonly caused by?

<p>Rh factor incompatibility. (B)</p> Signup and view all the answers

In what way do anti-Rh antibodies affect the fetus?

<p>They cause complement-mediated lysis of fetal cells. (C)</p> Signup and view all the answers

How is sensitization defined in the context of Rh incompatibility?

<p>An Rh-negative mother carries an Rh-positive fetus. (A)</p> Signup and view all the answers

What is the role of specific antibodies in cytotoxic (Type II) hypersensitivity?

<p>They react with cell surface antigens interpreted as foreign. (D)</p> Signup and view all the answers

What damage occurs due to the inflammatory response in cytotoxic hypersensitivity?

<p>Causes destruction of the cells to which antibodies are attached. (C)</p> Signup and view all the answers

What is the primary role of B cells in the allergic response?

<p>To produce antibodies against specific allergens (B)</p> Signup and view all the answers

What do IgE antibodies bind to during an allergy response?

<p>Mast cell receptors (C)</p> Signup and view all the answers

What is a potential outcome of generalized anaphylaxis?

<p>Shock due to low blood pressure (C)</p> Signup and view all the answers

Which cytokine is primarily involved in driving the proliferation and differentiation of B cells into plasma cells?

<p>IL-4 (B)</p> Signup and view all the answers

What happens during the degranulation of mast cells and basophils?

<p>Increased blood vessel dilation and fluid loss (D)</p> Signup and view all the answers

Which of the following substances can trigger an allergic response mediated by IgE?

<p>Environmental antigens like dust and molds (B)</p> Signup and view all the answers

What physiological effect do histamines have on blood vessels?

<p>Dilate blood vessels (A)</p> Signup and view all the answers

What characterizes the sensitization process in allergies?

<p>The binding of allergens to IgE antibodies on mast cells (A)</p> Signup and view all the answers

During an allergic reaction, what do armed TH cells release to promote B cell activity?

<p>Cytokines (C)</p> Signup and view all the answers

What is cross-linking of IgE antibodies indicative of in an allergic response?

<p>Degranulation of mast cells (B)</p> Signup and view all the answers

Flashcards

Hypersensitivity

An exaggerated or inappropriate immune response to an allergen.

Type I Hypersensitivity

Immediate allergic reaction caused by previous exposure to allergens.

Anaphylaxis

Severe, life-threatening allergic reaction from allergens.

Type II Hypersensitivity

Cytotoxic reaction caused by antibodies against own cells.

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Type III Hypersensitivity

Reaction elicited by immune complexes in blood or tissues.

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Type IV Hypersensitivity

Delayed hypersensitivity mediated by T-cells, not antibodies.

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Desensitization

Immunotherapy process to reduce sensitivity to allergens.

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Cells involved in hypersensitivity

Includes T-cells, B-cells, and various antibodies.

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B cells

Lymphocytes that produce antibodies in response to allergens.

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Plasma cells

Differentiated B cells that secrete antibodies, specifically IgE.

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IgE antibodies

A type of antibody produced by plasma cells to combat allergens.

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Mast cells

Cells that release histamines during an allergic reaction.

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Cytokines

Signaling proteins that aid in cell communication and immune responses.

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Degranulation

The process where mast cells release stored chemicals like histamine.

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Histamines

Chemicals released by mast cells causing inflammation and allergic symptoms.

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Generalized anaphylaxis

A severe allergic reaction affecting the entire body, can cause shock.

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Shock

A life-threatening condition with insufficient blood flow to vital organs.

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Allergen

A substance that triggers an allergic reaction in sensitive individuals.

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Allergy Treatment

Methods to reduce allergy symptoms but not cure the disorder.

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Normal Allergic Reaction

Natural exposure to allergens activates the immune response via helper T cells.

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Role of IgE

Immunoglobulin E helps in allergic reactions by binding to allergens.

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Denatured Allergen

Modified allergen that prevents IgE production by B cells.

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Cytotoxicity

The process where cells are killed due to antibody binding and complement activation.

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Complement System

A group of proteins that enhance the ability of antibodies to kill pathogens or infected cells.

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ADCC (Antibody-Dependent Cellular Cytotoxicity)

A mechanism where immune cells kill target cells that are coated with antibodies.

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Transfusion Reaction

An immune response when incompatible blood types are mixed, causing blood cell destruction.

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ABO Blood Group System

Classification of human blood based on the presence of A and B antigens on red cells.

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Hemolytic Disease of Newborn

A condition where maternal antibodies attack fetal red blood cells due to Rh incompatibility.

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Surface Antigens

Molecules on cell surfaces that trigger immune responses when recognized by antibodies.

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Blood Typing

Determining blood type based on antigens present.

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Rh Factor

An antigen present on red blood cells.

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Hemolytic Disease of the Newborn

Condition caused by Rh incompatibility.

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Primary Immune Response

Initial response to a foreign antigen with antibodies.

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Complement-Mediated Lysis

Cell destruction facilitated by the complement system.

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Rh Incompatibility

A condition where an Rh- mother creates antibodies against Rh+ fetal blood cells.

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Anti-Rh Antibodies

Antibodies produced by an Rh- mother when exposed to Rh+ blood.

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Memory Cells in Pregnancy

Cells that remain in the body and trigger an immune response in later pregnancies.

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Fetal Blood Exposure

Occurs during childbirth when some fetal blood enters the mother's circulation.

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Hemolytic Disease of the Newborn (HDN)

Condition resulting from Rh incompatibility leading to destruction of fetal red blood cells.

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Rh Immune-Globulin Shots

Injections given to Rh- mothers to prevent antibody formation against Rh+ blood.

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Effects on Liver and Spleen

Enlargement of these organs due to efforts in removing damaged red blood cells.

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First Shot Timing

The initial Rh immune-globulin shot is given around the 28th week of pregnancy.

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Study Notes

Hypersensitivity Overview

  • Hypersensitivity is an exaggerated or inappropriate immune response to a foreign substance.
  • Four types of hypersensitivity exist: Type I (immediate), Type II (cytotoxic), Type III (immune complex), and Type IV (cell-mediated).

Type I Hypersensitivity (Anaphylaxis)

  • IgE causes immediate (Type I) hypersensitivities.
  • Characterized by an immediate reaction in a sensitized individual, typically within minutes of exposure.
  • Genetic predisposition increases risk (20-30%).
  • Classified as local or generalized anaphylaxis.
  • Anaphylaxis is the term for IgE-mediated allergic reactions.

Localized Anaphylaxis

  • Common allergic reactions: hives (urticaria), hay fever, asthma.
  • Hives (urticaria): Itchy skin rash characterized by welts (wheals) surrounded by redness.
  • Hay fever: Allergic reaction to inhaled antigens, causing runny nose, itchy eyes, sneezing.
  • Asthma: Respiratory allergy leading to airway constriction, mucus secretion, and shortness of breath.

Generalized Anaphylaxis

  • Rare and potentially life-threatening.
  • Characterized by body-wide inflammation and potential shock.
  • Widespread release of mediators, causing significant blood vessel dilation and fluid leakage, leading to a rapid decrease in blood pressure, potentially leading to organ damage or failure.
  • Common triggers: insect stings, peanuts, penicillin.

Treatment and Prevention

  • Avoidance of known allergens is crucial.
  • Desensitization (hyposensitization) is a treatment method that gradually introduces increasing concentrations of allergen to modify the immune response.
  • Various medications can manage symptoms (e.g. antihistamines).

Type II Hypersensitivity (Cytotoxic)

  • Antibodies react with cell surface antigens, damaging the cell through complement activation or antibody-dependent cellular cytotoxicity (ADCC).
  • Examples include transfusion reactions and hemolytic disease of the newborn.
  • Transfusion reactions: Occur when blood groups are incompatible, leading to lysis of red blood cells and a range of symptoms.
  • Hemolytic disease of the newborn: Develops when the mother's antibodies attack the fetus's red blood cells due to Rh incompatibility. Rh-negative mothers can develop antibodies against Rh-positive fetal blood cells, causing hemolysis in subsequent pregnancies.

Type III Hypersensitivity (Immune Complex)

  • Antibodies bind to soluble antigens, forming immune complexes that deposit in tissues.
  • This triggers inflammation and tissue damage.
  • Examples include serum sickness, farmer's lung, etc.

Type IV Hypersensitivity (Cell-Mediated)

  • Delayed-type hypersensitivity, involving T cells.
  • Characterized by a delayed response (24-72 hours post-exposure).
  • Examples like allergic contact dermatitis, tuberculin skin test.

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