Podcast
Questions and Answers
Which of the following is NOT a characteristic of Type II hypersensitivities?
Which of the following is NOT a characteristic of Type II hypersensitivities?
- Lead to cell injury or death
- Involve degranulation and histamine production (correct)
- Involve antibody-dependent cellular cytotoxicity (ADCC)
- Can be triggered by transfusion reactions
What is the primary role of surface antigens on red blood cells in relation to blood transfusions?
What is the primary role of surface antigens on red blood cells in relation to blood transfusions?
- They determine the blood type and are responsible for activating the immune response during incompatible transfusions. (correct)
- They trigger the release of histamine, leading to an allergic reaction in case of a mismatch.
- They directly cause degranulation of mast cells, leading to inflammation and tissue damage.
- They initiate clot formation in the blood vessels, preventing the recipient's blood from clotting properly.
Which of the following mechanisms is NOT involved in the destruction of cells in Type II hypersensitivities?
Which of the following mechanisms is NOT involved in the destruction of cells in Type II hypersensitivities?
- Antibody-dependent cellular cytotoxicity (ADCC)
- Release of histamine by mast cells (correct)
- Direct binding of antibodies to cell surface antigens
- Activation of the complement system
What happens when an individual receives a transfusion of blood with incompatible antigens?
What happens when an individual receives a transfusion of blood with incompatible antigens?
What is the key difference between Type I and Type II hypersensitivities?
What is the key difference between Type I and Type II hypersensitivities?
Why is it crucial to determine a patient's blood type before a blood transfusion?
Why is it crucial to determine a patient's blood type before a blood transfusion?
What is the mechanism that leads to hemolytic disease of the newborn?
What is the mechanism that leads to hemolytic disease of the newborn?
Which of the following statements regarding transfusion reactions is NOT true?
Which of the following statements regarding transfusion reactions is NOT true?
What is the primary reason why an Rh+ child's first pregnancy with an Rh- mother is typically uneventful?
What is the primary reason why an Rh+ child's first pregnancy with an Rh- mother is typically uneventful?
What is the main consequence of repeated Rh+ blood cell exposure to an Rh- mother's immune system?
What is the main consequence of repeated Rh+ blood cell exposure to an Rh- mother's immune system?
What is the medical term for the condition affecting a baby due to Rh incompatibility?
What is the medical term for the condition affecting a baby due to Rh incompatibility?
What is the primary role of the enlarged liver and spleen in a baby affected by Rh incompatibility?
What is the primary role of the enlarged liver and spleen in a baby affected by Rh incompatibility?
What is the significance of the first Rh immune globulin shot administered to the Rh- mother during her pregnancy?
What is the significance of the first Rh immune globulin shot administered to the Rh- mother during her pregnancy?
In the context of Rh incompatibility, what is meant by 'sensitization'?
In the context of Rh incompatibility, what is meant by 'sensitization'?
During which trimester of a pregnancy is the first Rh immune globulin shot typically given?
During which trimester of a pregnancy is the first Rh immune globulin shot typically given?
What is the main reason why doctors administer a series of two Rh immune globulin shots during a pregnancy?
What is the main reason why doctors administer a series of two Rh immune globulin shots during a pregnancy?
What is the primary trigger for Immediate (Type I) Hypersensitivity reactions?
What is the primary trigger for Immediate (Type I) Hypersensitivity reactions?
Which type of hypersensitivity is associated with an immune response to antigens on cells?
Which type of hypersensitivity is associated with an immune response to antigens on cells?
Which of the following best defines hypersensitivity?
Which of the following best defines hypersensitivity?
What distinguishes Cytotoxic (Type II) Hypersensitivity from other types?
What distinguishes Cytotoxic (Type II) Hypersensitivity from other types?
What is the main mechanism behind Type I Hypersensitivity reactions?
What is the main mechanism behind Type I Hypersensitivity reactions?
Which type of hypersensitivity is linked to immune complexes that elicit an inflammatory response?
Which type of hypersensitivity is linked to immune complexes that elicit an inflammatory response?
What does immunotherapy by desensitization aim to achieve?
What does immunotherapy by desensitization aim to achieve?
Which statement is true regarding Cell-mediated (Type IV) Hypersensitivity?
Which statement is true regarding Cell-mediated (Type IV) Hypersensitivity?
What is the primary role of helper T cells in a normal allergic reaction?
What is the primary role of helper T cells in a normal allergic reaction?
What type of antibodies are produced by plasma cells during a normal allergic reaction?
What type of antibodies are produced by plasma cells during a normal allergic reaction?
Which of the following statements about desensitization is accurate?
Which of the following statements about desensitization is accurate?
What occurs during a second exposure to an allergen in a normal allergic reaction?
What occurs during a second exposure to an allergen in a normal allergic reaction?
In type II hypersensitivities, what type of antibodies are mainly produced?
In type II hypersensitivities, what type of antibodies are mainly produced?
What is the effect of denatured allergens in the immune response?
What is the effect of denatured allergens in the immune response?
Which immune cell type binds to IgG in type II hypersensitivity?
Which immune cell type binds to IgG in type II hypersensitivity?
What characterizes the symptoms alleviated by allergy treatments?
What characterizes the symptoms alleviated by allergy treatments?
What occurs in an Rh-negative mother carrying an Rh-positive fetus for the first time?
What occurs in an Rh-negative mother carrying an Rh-positive fetus for the first time?
What leads to hemolytic disease of the newborn with a subsequent Rh-positive pregnancy?
What leads to hemolytic disease of the newborn with a subsequent Rh-positive pregnancy?
Which of the following describes the Rh factor in blood typing?
Which of the following describes the Rh factor in blood typing?
What is erythroblastosis fetalis most commonly caused by?
What is erythroblastosis fetalis most commonly caused by?
In what way do anti-Rh antibodies affect the fetus?
In what way do anti-Rh antibodies affect the fetus?
How is sensitization defined in the context of Rh incompatibility?
How is sensitization defined in the context of Rh incompatibility?
What is the role of specific antibodies in cytotoxic (Type II) hypersensitivity?
What is the role of specific antibodies in cytotoxic (Type II) hypersensitivity?
What damage occurs due to the inflammatory response in cytotoxic hypersensitivity?
What damage occurs due to the inflammatory response in cytotoxic hypersensitivity?
What is the primary role of B cells in the allergic response?
What is the primary role of B cells in the allergic response?
What do IgE antibodies bind to during an allergy response?
What do IgE antibodies bind to during an allergy response?
What is a potential outcome of generalized anaphylaxis?
What is a potential outcome of generalized anaphylaxis?
Which cytokine is primarily involved in driving the proliferation and differentiation of B cells into plasma cells?
Which cytokine is primarily involved in driving the proliferation and differentiation of B cells into plasma cells?
What happens during the degranulation of mast cells and basophils?
What happens during the degranulation of mast cells and basophils?
Which of the following substances can trigger an allergic response mediated by IgE?
Which of the following substances can trigger an allergic response mediated by IgE?
What physiological effect do histamines have on blood vessels?
What physiological effect do histamines have on blood vessels?
What characterizes the sensitization process in allergies?
What characterizes the sensitization process in allergies?
During an allergic reaction, what do armed TH cells release to promote B cell activity?
During an allergic reaction, what do armed TH cells release to promote B cell activity?
What is cross-linking of IgE antibodies indicative of in an allergic response?
What is cross-linking of IgE antibodies indicative of in an allergic response?
Flashcards
Hypersensitivity
Hypersensitivity
An exaggerated or inappropriate immune response to an allergen.
Type I Hypersensitivity
Type I Hypersensitivity
Immediate allergic reaction caused by previous exposure to allergens.
Anaphylaxis
Anaphylaxis
Severe, life-threatening allergic reaction from allergens.
Type II Hypersensitivity
Type II Hypersensitivity
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Type III Hypersensitivity
Type III Hypersensitivity
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Type IV Hypersensitivity
Type IV Hypersensitivity
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Desensitization
Desensitization
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Cells involved in hypersensitivity
Cells involved in hypersensitivity
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B cells
B cells
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Plasma cells
Plasma cells
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IgE antibodies
IgE antibodies
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Mast cells
Mast cells
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Cytokines
Cytokines
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Degranulation
Degranulation
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Histamines
Histamines
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Generalized anaphylaxis
Generalized anaphylaxis
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Shock
Shock
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Allergen
Allergen
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Allergy Treatment
Allergy Treatment
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Normal Allergic Reaction
Normal Allergic Reaction
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Role of IgE
Role of IgE
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Denatured Allergen
Denatured Allergen
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Cytotoxicity
Cytotoxicity
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Complement System
Complement System
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ADCC (Antibody-Dependent Cellular Cytotoxicity)
ADCC (Antibody-Dependent Cellular Cytotoxicity)
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Transfusion Reaction
Transfusion Reaction
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ABO Blood Group System
ABO Blood Group System
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Hemolytic Disease of Newborn
Hemolytic Disease of Newborn
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Surface Antigens
Surface Antigens
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Blood Typing
Blood Typing
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Rh Factor
Rh Factor
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Hemolytic Disease of the Newborn
Hemolytic Disease of the Newborn
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Primary Immune Response
Primary Immune Response
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Complement-Mediated Lysis
Complement-Mediated Lysis
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Rh Incompatibility
Rh Incompatibility
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Anti-Rh Antibodies
Anti-Rh Antibodies
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Memory Cells in Pregnancy
Memory Cells in Pregnancy
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Fetal Blood Exposure
Fetal Blood Exposure
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Hemolytic Disease of the Newborn (HDN)
Hemolytic Disease of the Newborn (HDN)
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Rh Immune-Globulin Shots
Rh Immune-Globulin Shots
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Effects on Liver and Spleen
Effects on Liver and Spleen
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First Shot Timing
First Shot Timing
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Study Notes
Hypersensitivity Overview
- Hypersensitivity is an exaggerated or inappropriate immune response to a foreign substance.
- Four types of hypersensitivity exist: Type I (immediate), Type II (cytotoxic), Type III (immune complex), and Type IV (cell-mediated).
Type I Hypersensitivity (Anaphylaxis)
- IgE causes immediate (Type I) hypersensitivities.
- Characterized by an immediate reaction in a sensitized individual, typically within minutes of exposure.
- Genetic predisposition increases risk (20-30%).
- Classified as local or generalized anaphylaxis.
- Anaphylaxis is the term for IgE-mediated allergic reactions.
Localized Anaphylaxis
- Common allergic reactions: hives (urticaria), hay fever, asthma.
- Hives (urticaria): Itchy skin rash characterized by welts (wheals) surrounded by redness.
- Hay fever: Allergic reaction to inhaled antigens, causing runny nose, itchy eyes, sneezing.
- Asthma: Respiratory allergy leading to airway constriction, mucus secretion, and shortness of breath.
Generalized Anaphylaxis
- Rare and potentially life-threatening.
- Characterized by body-wide inflammation and potential shock.
- Widespread release of mediators, causing significant blood vessel dilation and fluid leakage, leading to a rapid decrease in blood pressure, potentially leading to organ damage or failure.
- Common triggers: insect stings, peanuts, penicillin.
Treatment and Prevention
- Avoidance of known allergens is crucial.
- Desensitization (hyposensitization) is a treatment method that gradually introduces increasing concentrations of allergen to modify the immune response.
- Various medications can manage symptoms (e.g. antihistamines).
Type II Hypersensitivity (Cytotoxic)
- Antibodies react with cell surface antigens, damaging the cell through complement activation or antibody-dependent cellular cytotoxicity (ADCC).
- Examples include transfusion reactions and hemolytic disease of the newborn.
- Transfusion reactions: Occur when blood groups are incompatible, leading to lysis of red blood cells and a range of symptoms.
- Hemolytic disease of the newborn: Develops when the mother's antibodies attack the fetus's red blood cells due to Rh incompatibility. Rh-negative mothers can develop antibodies against Rh-positive fetal blood cells, causing hemolysis in subsequent pregnancies.
Type III Hypersensitivity (Immune Complex)
- Antibodies bind to soluble antigens, forming immune complexes that deposit in tissues.
- This triggers inflammation and tissue damage.
- Examples include serum sickness, farmer's lung, etc.
Type IV Hypersensitivity (Cell-Mediated)
- Delayed-type hypersensitivity, involving T cells.
- Characterized by a delayed response (24-72 hours post-exposure).
- Examples like allergic contact dermatitis, tuberculin skin test.
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