18 Questions
What is the mechanism of Type III hypersensitivity reaction?
Immune complex deposition and activation of complement system
What is the primary defect in autoimmune diseases?
Failure of immune system to distinguish between 'self' and 'nonself'
What is the primary cause of immunodeficiency in HIV infection?
Infection of T helper cells
What is the characteristic feature of Delayed Hypersensitivity Reaction?
Activation of macrophages and formation of granulomas
What is the characteristic of Type IV hypersensitivity reaction?
T cell-mediated reaction
What is the route of transmission of HIV virus?
Sexual transmission
What type of hypersensitivity reaction is mediated by immune complexes?
Type III
Which type of hypersensitivity reaction is characterized by a delayed onset and is mediated by T cells?
Type IV
What is the primary mechanism of Type II hypersensitivity reactions?
Antibody-mediated cytotoxicity
What is the primary mechanism of Type I hypersensitivity reactions?
IgE-mediated degranulation of mast cells
Which type of hypersensitivity reaction is most commonly associated with autoimmune diseases?
Type II
What is the primary difference between immediate and delayed hypersensitivity reactions?
The duration of the reaction
What is the result of the deposition of antigen-antibody complexes on tissues in Type III reactions?
Activation of the complement system and inflammatory reaction
What is the mechanism of muscle weakness in myasthenia gravis?
Antibodies to acetylcholine receptors of skeletal muscle
What is the effect of histamine release from mast cells?
Vasodilatation and increased vascular permeability
What type of reaction is characterized by the binding of antibodies to cell surface antigens on specific cells and tissues?
Type II hypersensitivity
What is the term for the increased migration of eosinophils and neutrophils at the site of local injury?
Eosinophilia and neutrophilia
What is the result of incompatible or mismatched blood transfusion?
Type II hypersensitivity reaction
Understand the concept of hypersensitivity reactions, classified into immediate and delayed types. Learn about the immune response and its mediation by humoral antibodies. Test your knowledge on pathophysiology of immune system diseases.
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