Hypersensitivity Reactions: Immunity and Disease Quiz

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What is the principal immunologic mechanism responsible for Type 1 hypersensitivity reactions?

IgE-mediated (correct)

Cellular effectors (T lymphocyte-mediated)

Antigen-Ab complexes

Ag-driven specific IgM or IgG

Which type of allergens typically trigger Type 1 hypersensitivity reactions?

Dust and mold spores

Chemicals and metals

Bacteria and viruses

Pollen, food, and drugs (correct)

What is the main effect of Type 1 hypersensitivity reactions on the body?

Decreased production of antigens

Rapid vascular leakage and mucosal secretions (correct)

Inhibition of immune response

Suppression of antibody production

Which type of hypersensitivity reaction is driven by cellular effectors?

Type 4 Signup and view all the answers

What is the characteristic immunoglobulin involved in Type 1 hypersensitivity reactions?

IgE Signup and view all the answers

Which type of antigen triggers Type 3 hypersensitivity reactions?

Soluble antigen-antibody complexes Signup and view all the answers

What is the term used to describe individuals with a genetic and environmental propensity to develop Type I hypersensitivity reactions?

Atopic Signup and view all the answers

What is the approximate risk of an individual developing Type I hypersensitivity if both parents are atopic?

60% Signup and view all the answers

What is the primary role of allergen-specific IgE antibodies in immediate hypersensitivity reactions?

Release vasoactive amines and lipid mediators Signup and view all the answers

Which immune response is associated with Type I hypersensitivity?

Type 2 Signup and view all the answers

What are the primary mediators involved in the late-phase reaction of immediate hypersensitivity?

Cytokines and chemokines Signup and view all the answers

What is the characteristic vascular response during immediate hypersensitivity reactions?

Wheal-and-flare reaction Signup and view all the answers

What type of allergens are most commonly associated with airborne allergies?

Dry particles carrying soluble proteins Signup and view all the answers

What characteristic favors type 2 immunity and IgE production in response to inhaled allergens?

Protease activity Signup and view all the answers

What do atopic individuals produce high levels of in response to certain substances?