23 Questions
Which cells are involved in the adaptive immune response?
T lymphocytes
What is the primary function of dendritic cells in the immune system?
To present antigens to T cells
Which type of hypersensitivity reaction involves IgE antibodies and mast cell activation?
Type 1 hypersensitivity
Which of the following is NOT a player of innate immunity?
Platelets
What is the function of the neutrophil granules?
To produce reactive oxygen species
What is the most common cause of infection in patients with Chronic Granulomatous Disease?
Staphylococcus aureus
What is the defect in innate immunity that causes Chronic Granulomatous Disease?
Defect in gp91phox component of NADPH oxidase
Which cells in our body present self-antigens on MHC-I?
Dendritic cells
Which cells express MHC-I?
All nucleated cells
Which cells usually present antigens from extracellular pathogens?
B-cells
Which cells recognize activating ligands universally expressed on nucleated cells?
Natural Killer (NK) cells
Which cells of innate immunity fight parasitic infection and contribute to allergic reactions?
Eosinophils
Which cells of innate immunity have additional capabilities for killing microbes, including acidification of phagosome and influx of reactive metals?
Macrophages
Which cells of innate immunity recognize peptidoglycan, lipoproteins, and bacterial LPS?
Macrophages
Which cells of adaptive immunity produce antibodies and develop in the bone marrow?
B cells
What are key signs and symptoms that indicate that someone is (or is likely) experiencing anaphylaxis?
Chest tightness and difficulty breathing
Why is it so important to recognize and treat anaphylaxis quickly?
To prevent long-term damage to organs
What type of hypersensitivity reaction does anaphylaxis fall under?
Type I
What are other common causes or triggers for anaphylaxis?
Latex allergy
Which of the following factors can lead to a failure of self-tolerance and the development of autoimmunity?
Genetic inheritance of susceptibility genes
What are the main factors involved in the current concepts of immunological tolerance?
Recognition of self and non-self antigens by antigen reactive T cells
Which type of immune reaction is associated with systemic lupus erythematosus (SLE)?
Type III - circulating immune complexes
Which type of hypersensitivity reaction is antibody independent and mediated by T cells?
Type IV - delayed-type hypersensitivity
Test your knowledge on the human immune system and its response to self-antigens. Explore the role of MHC-I and MHC-II in protecting the body from foreign invaders. Learn about T-cell receptors and the process of clonal expansion.
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