T1 L9: Overview and classification of immunological diseases (MTz)
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Questions and Answers

Which type of hypersensitivity reaction is characterized by the formation of complexes between antigens and antibodies?

  • Type 1 hypersensitivity
  • Type 4 hypersensitivity
  • Type 2 hypersensitivity
  • Type 3 hypersensitivity (correct)

What is the main characteristic of type 2 hypersensitivity reaction?

  • It is characterized by the release of histamine
  • It is caused by a pathogenic antibody (correct)
  • It is caused by an environmental allergen
  • It is mediated by immunity but not autoimmune or allergic

Which immunological component is involved in all diseases, including cancer and atherosclerosis?

  • Tolerance
  • Histamine
  • Antibodies
  • The immune system (correct)

What classification scheme is commonly used to understand immunologically mediated diseases?

<p>Kellen Coombs classification (B)</p> Signup and view all the answers

Which classification system is discussed in the text?

<p>Callan Coombs (B)</p> Signup and view all the answers

What is the aim of the lecture mentioned in the text?

<p>To introduce a classification system for immunological diseases (C)</p> Signup and view all the answers

What can happen in situations of too little immuno immunity?

<p>The immune system may fail to control infection (A)</p> Signup and view all the answers

What is the main topic of the lecture mentioned at the end of the series?

<p>Immunodeficiency (C)</p> Signup and view all the answers

Which type of hypersensitivity is caused by complexes of antibody and antigen?

<p>Type three hypersensitivity (B)</p> Signup and view all the answers

Where do soluble immune complexes usually get removed?

<p>Spleen (B)</p> Signup and view all the answers

What are the situations that can lead to the formation of insoluble immune complexes?

<p>A large excess of antigen or a large quantity of antibody (D)</p> Signup and view all the answers

What is an example of a condition where insoluble immune complexes can be seen?

<p>Infective endocarditis (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction involves inflammation directly mediated by T cells?

<p>Type three hypersensitivity (C)</p> Signup and view all the answers

What is the main characteristic of type one hypersensitivity?

<p>It involves the release of histamine from mast cells (B)</p> Signup and view all the answers

Which blood group is considered a universal donor?

<p>Blood Group O (D)</p> Signup and view all the answers

What is the main function of IgG antibodies in type one hypersensitivity?

<p>To pick up antibodies from the blood (B)</p> Signup and view all the answers

Which process is responsible for causing an immunologically mediated reaction?

<p>Ionisation (A)</p> Signup and view all the answers

What is the role of a sensitising agent in the immune response?

<p>Binding to proteins (B)</p> Signup and view all the answers

What is the main characteristic of sensitising agents?

<p>Small and highly reactive molecules (C)</p> Signup and view all the answers

What is the protein hatching complex formed by?

<p>Sensitising agents and self proteins (D)</p> Signup and view all the answers

Is sensitisation process considered an autoimmune disease?

<p>No (A)</p> Signup and view all the answers

What is the role of Langerhans cells in the immune response?

<p>Presenting protein complexes (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction is exemplified by the case of mismatched blood transfusion described in the text?

<p>Type II hypersensitivity reaction (D)</p> Signup and view all the answers

What is the antigen system involved in the development of haemolytic disease of the newborn?

<p>D (A)</p> Signup and view all the answers

What is the purpose of giving A.D antibody to a racist negative mother during pregnancy?

<p>To prevent sensitization to foetal red cells (B)</p> Signup and view all the answers

How does autoimmune haemolysis lead to the destruction of red cells?

<p>By both removal by macrophages and activation of terminal complement (A)</p> Signup and view all the answers

Which type of hypersensitivity is characterized by symptoms that are directly mediated by pathogenic T cells?

<p>Type IV hypersensitivity (D)</p> Signup and view all the answers

What is the old-fashioned name for hypersensitivity pneumonitis?

<p>Extrinsic allergic alveolitis (A)</p> Signup and view all the answers

What are the two classic situations associated with hypersensitivity pneumonitis?

<p>Thermal filling mold spores and pigeon feather antigens (D)</p> Signup and view all the answers

What is the main difference between hypersensitivity pneumonitis and allergy?

<p>Hypersensitivity pneumonitis is delayed while allergy is immediate (A)</p> Signup and view all the answers

Which cells are responsible for releasing histamine, tryptase, and other pre-formed mediators in type 2 hypersensitivity reactions?

<p>Tissue mast cells and circulating basophils (B)</p> Signup and view all the answers

What is the main effect of histamine release in type 2 hypersensitivity reactions?

<p>Rapid degranulation of the mast cell (C)</p> Signup and view all the answers

Which blood group system is considered the major one?

<p>ABO (D)</p> Signup and view all the answers

What is the secondary classification in the blood group system?

<p>Rhesus (B)</p> Signup and view all the answers

What is the potential consequence of maternal sensitization to fetal red cells during pregnancy?

<p>Hydrops fetalis (C)</p> Signup and view all the answers

What is the purpose of giving anti-D IgG to Rhesus-negative mothers during pregnancy?

<p>To prevent sensitization (D)</p> Signup and view all the answers

What is the potential risk reduction achieved by giving anti-D IgG to Rhesus-negative mothers during pregnancy?

<p>0% per pregnancy (B)</p> Signup and view all the answers

Which type of hypersensitivity reaction is characterized by the formation of complexes between antigens and antibodies?

<p>Type III hypersensitivity (A)</p> Signup and view all the answers

What are isoantibodies and what do they develop against?

<p>Antibodies that develop against similar antigens on surface of gut bacteria and cross-react with red cell antigens (A)</p> Signup and view all the answers

What is the main characteristic of type III hypersensitivity reactions?

<p>Formation of immune complexes (C)</p> Signup and view all the answers

What is the condition characterized by the destruction of fetal red cells due to isoantibodies?

<p>Haemolytic disease of the newborn (C)</p> Signup and view all the answers

Which one of the following situations can lead to the formation of insoluble immune complexes?

<p>All of the above (D)</p> Signup and view all the answers

What is the potential consequence of autoimmune haemolysis in the fetus?

<p>Hydrops fetalis (D)</p> Signup and view all the answers

Which one of the following is an example of a condition where insoluble immune complexes can be seen?

<p>Infective endocarditis (B)</p> Signup and view all the answers

What is the main characteristic of sensitising agents?

<p>They can bind to a protein to alter its immunogenicity (A)</p> Signup and view all the answers

Which one of the following is an example of a sensitising agent?

<p>Nickel (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction is exemplified by the case of contact dermatitis?

<p>Type IV hypersensitivity (B)</p> Signup and view all the answers

What is the main difference between hypersensitivity pneumonitis and allergy?

<p>The type of antigen involved (B)</p> Signup and view all the answers

Which type of hypersensitivity reaction involves inflammation directly mediated by T cells?

<p>Type IV hypersensitivity (A)</p> Signup and view all the answers

What classification scheme is commonly used to understand immunologically mediated diseases?

<p>Gell and Coombes classification (C)</p> Signup and view all the answers

Which classification system is commonly used to understand immunologically mediated diseases?

<p>Type I-IV hypersensitivity reactions (A)</p> Signup and view all the answers

What is the main characteristic of type 1 hypersensitivity?

<p>IgE antibody directed against allergen triggers mast cell degranulation (D)</p> Signup and view all the answers

What is the main characteristic of type 2 hypersensitivity reaction?

<p>A pathogenic antibody directly causes diseases (B)</p> Signup and view all the answers

Which type of hypersensitivity reaction involves inflammation directly mediated by T cells?

<p>Type IV (D)</p> Signup and view all the answers

What is the antigen system involved in the development of haemolytic disease of the newborn?

<p>IgG antibody (B)</p> Signup and view all the answers

What is an example of a condition where insoluble immune complexes can be seen?

<p>Serum sickness (C)</p> Signup and view all the answers

Which process is responsible for causing an immunologically mediated reaction?

<p>Inappropriate activation of the immune system (C)</p> Signup and view all the answers

What is the main function of IgG antibodies in type 1 hypersensitivity?

<p>Trigger mast cell degranulation (A)</p> Signup and view all the answers

What are the situations that can lead to the formation of insoluble immune complexes?

<p>All of the above (D)</p> Signup and view all the answers

What can happen in situations of too little immunity?

<p>Infection control can fail (A)</p> Signup and view all the answers

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