Hyperparathyroidism Manifestations Quiz
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Questions and Answers

What is the primary cause of Milk-alkali Syndrome?

  • Widespread use of calcium carbonate as prophylaxis for osteoporosis (correct)
  • Granulomatous disorders like sarcoidosis
  • Excessive intake of vitamin D
  • Metastatic bone cancer

Which of the following is a common manifestation of Milk-alkali Syndrome?

  • Hypoglycemia
  • Hypercalcemia (correct)
  • Hypertension
  • Hypocalcemia

What is the underlying mechanism for hypercalcemia in granulomatous disorders?

  • Increased bone resorption
  • Decreased parathyroid hormone (PTH) secretion
  • Decreased renal calcium reabsorption
  • Increased vitamin D synthesis by macrophages in granulomatous tissue (correct)

What is the primary mechanism of hypercalcemia in Humoral Hypercalcemia of Malignancy (HHM)?

<p>Increased secretion of parathyroid hormone-related protein (PTHrP) (C)</p> Signup and view all the answers

Which of the following cancers is LEAST likely to be associated with Humoral Hypercalcemia of Malignancy (HHM)?

<p>Leukemia (D)</p> Signup and view all the answers

Which of the following is a common granulomatous disorder that can lead to hypercalcemia?

<p>Sarcoidosis (D)</p> Signup and view all the answers

What is the main reason for parathyroid gland hyperplasia due to resistance to PTH?

<p>Chronic stimulation (C)</p> Signup and view all the answers

What is the mechanism behind hypercalcemia in malignancy-related cases with bone metastases?

<p>Secretion of lymphokines with osteoclast potentiating activity (A)</p> Signup and view all the answers

In conditions with hypercalcemia without bone metastases, which hormone is responsible for the increase in calcium levels?

<p>PTH-related peptide (PTHrP) (A)</p> Signup and view all the answers

Which type of cancer is not associated with humoral hypercalcemia of malignancy (HHM)?

<p>Medullary thyroid carcinoma (A)</p> Signup and view all the answers

How does humoral hypercalcemia of malignancy (HHM) differ from hypercalcemia with bone metastases?

<p>HHM involves PTH-related peptide (PTHrP) production. (D)</p> Signup and view all the answers

What is the primary cause of humoral hypercalcemia of malignancy?

<p>Overproduction of parathyroid hormone-related protein (PTHrP) (B)</p> Signup and view all the answers

Which of the following statements about PTHrP is true?

<p>It can cause hypercalcemia during lactation (D)</p> Signup and view all the answers

What is the primary difference between the effects of PTH and PTHrP?

<p>PTH is regulated by feedback, while PTHrP is not regulated by calcium levels (D)</p> Signup and view all the answers

In the context of hypercalcemia of malignancy, what is the purpose of measuring PTHrP levels?

<p>To differentiate between primary hyperparathyroidism and hypercalcemia of malignancy (C)</p> Signup and view all the answers

Which of the following statements about the intact PTH assay is true?

<p>It does not cross-react with circulating PTHrP (A)</p> Signup and view all the answers

Which of the following is a characteristic of hypoparathyroidism?

<p>Decreased calcium levels and increased phosphate levels (C)</p> Signup and view all the answers

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