Hyperparathyroidism Manifestations Quiz
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Questions and Answers

What is the primary cause of Milk-alkali Syndrome?

  • Widespread use of calcium carbonate as prophylaxis for osteoporosis (correct)
  • Granulomatous disorders like sarcoidosis
  • Excessive intake of vitamin D
  • Metastatic bone cancer
  • Which of the following is a common manifestation of Milk-alkali Syndrome?

  • Hypoglycemia
  • Hypercalcemia (correct)
  • Hypertension
  • Hypocalcemia
  • What is the underlying mechanism for hypercalcemia in granulomatous disorders?

  • Increased bone resorption
  • Decreased parathyroid hormone (PTH) secretion
  • Decreased renal calcium reabsorption
  • Increased vitamin D synthesis by macrophages in granulomatous tissue (correct)
  • What is the primary mechanism of hypercalcemia in Humoral Hypercalcemia of Malignancy (HHM)?

    <p>Increased secretion of parathyroid hormone-related protein (PTHrP)</p> Signup and view all the answers

    Which of the following cancers is LEAST likely to be associated with Humoral Hypercalcemia of Malignancy (HHM)?

    <p>Leukemia</p> Signup and view all the answers

    Which of the following is a common granulomatous disorder that can lead to hypercalcemia?

    <p>Sarcoidosis</p> Signup and view all the answers

    What is the main reason for parathyroid gland hyperplasia due to resistance to PTH?

    <p>Chronic stimulation</p> Signup and view all the answers

    What is the mechanism behind hypercalcemia in malignancy-related cases with bone metastases?

    <p>Secretion of lymphokines with osteoclast potentiating activity</p> Signup and view all the answers

    In conditions with hypercalcemia without bone metastases, which hormone is responsible for the increase in calcium levels?

    <p>PTH-related peptide (PTHrP)</p> Signup and view all the answers

    Which type of cancer is not associated with humoral hypercalcemia of malignancy (HHM)?

    <p>Medullary thyroid carcinoma</p> Signup and view all the answers

    How does humoral hypercalcemia of malignancy (HHM) differ from hypercalcemia with bone metastases?

    <p>HHM involves PTH-related peptide (PTHrP) production.</p> Signup and view all the answers

    What is the primary cause of humoral hypercalcemia of malignancy?

    <p>Overproduction of parathyroid hormone-related protein (PTHrP)</p> Signup and view all the answers

    Which of the following statements about PTHrP is true?

    <p>It can cause hypercalcemia during lactation</p> Signup and view all the answers

    What is the primary difference between the effects of PTH and PTHrP?

    <p>PTH is regulated by feedback, while PTHrP is not regulated by calcium levels</p> Signup and view all the answers

    In the context of hypercalcemia of malignancy, what is the purpose of measuring PTHrP levels?

    <p>To differentiate between primary hyperparathyroidism and hypercalcemia of malignancy</p> Signup and view all the answers

    Which of the following statements about the intact PTH assay is true?

    <p>It does not cross-react with circulating PTHrP</p> Signup and view all the answers

    Which of the following is a characteristic of hypoparathyroidism?

    <p>Decreased calcium levels and increased phosphate levels</p> Signup and view all the answers

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