Hyperbilirubinemia and Physiological Factors Quiz
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Questions and Answers

What is the primary cause of hyperbilirubinemia?

  • Deficiency of glucose-6-phosphate dehydrogenase (G6PD)
  • Hemolytic disease
  • Excessive accumulation of bilirubin in the blood (correct)
  • Maternal diabetes
  • Which of the following is a physiologic factor that can cause hyperbilirubinemia?

  • Infant of a diabetic mother
  • Prematurity (correct)
  • Hypothyroidism
  • Galactosemia
  • Which of the following is NOT a risk factor for hyperbilirubinemia?

  • History of sibling with hyperbilirubinemia
  • Late preterm birth
  • Maternal race
  • Exclusive formula feeding (correct)
  • What is bilirubin a breakdown product of?

    <p>Red blood cells (RBCs)</p> Signup and view all the answers

    Which of the following conditions is NOT listed as a cause of hyperbilirubinemia?

    <p>Cystic fibrosis</p> Signup and view all the answers

    Which of the following is a criterion indicative of pathologic jaundice?

    <p>The text does not specify any criteria for pathologic jaundice</p> Signup and view all the answers

    What is the primary cause of Meconium Aspiration Syndrome?

    <p>Passage of meconium in utero</p> Signup and view all the answers

    Which of the following is a common clinical manifestation of Meconium Aspiration Syndrome in newborns?

    <p>Tachypnea and nasal flaring</p> Signup and view all the answers

    How can Meconium Aspiration Syndrome be diagnosed?

    <p>Laryngoscopy and chest radiographs</p> Signup and view all the answers

    Which of the following is a potential complication of severe Meconium Aspiration Syndrome?

    <p>Respiratory failure</p> Signup and view all the answers

    What is a common therapeutic management approach for Meconium Aspiration Syndrome immediately after birth?

    <p>Tracheal suctioning based on infant assessment</p> Signup and view all the answers

    How does hypoxic stress contribute to the development of Meconium Aspiration Syndrome?

    <p>Leading to airway blockage</p> Signup and view all the answers

    What is the purpose of administering surfactant in Respiratory Distress Syndrome treatment?

    <p>To increase respiratory compliance</p> Signup and view all the answers

    What is the role of the nurse in the administration of surfactant?

    <p>Assisting in delivery of the product</p> Signup and view all the answers

    What is the content of meconium that can lead to Meconium Aspiration Syndrome?

    <p>Bile and fats</p> Signup and view all the answers

    What can stimulate the release of meconium into the amniotic fluid in Meconium Aspiration Syndrome?

    <p>Hypoxia triggering the vagus reflex</p> Signup and view all the answers

    What is a complication associated with surfactant administration in Respiratory Distress Syndrome treatment?

    <p>Pulmonary hemorrhage and mucus plugging</p> Signup and view all the answers

    Why might suctioning be delayed after surfactant administration?

    <p>To allow the surfactant to be absorbed properly</p> Signup and view all the answers

    Study Notes

    Hyperbilirubinemia

    • Characterized by jaundice resulting from increased unconjugated or conjugated bilirubin
    • Bilirubin is a breakdown product of hemoglobin from RBC destruction
    • Causes:
      • Physiologic factors – prematurity
      • Association with breastfeeding or inadequate breast milk
      • Excess production of bilirubin – hemolytic disease, biochemical defects, bruises
      • Disturbed capacity of the liver to secrete conjugated bilirubin
      • Combined overproduction and underexcretion
      • Conditions or diseases (G6PD, deficiency, hypothyroidism, galactosemia, infant with diabetic mother)
      • Genetic predisposition to increased production (native American, Asians)
    • Risk factors:
      • Maternal race
      • Late preterm birth
      • Jaundice observed in the first 24 hours of life
      • Significant bruising
      • Cephalhematoma
      • Exclusive breastfeeding
      • Blood group incompatibility or hemolytic disease such as G6PD
      • History of sibling with hyperbilirubinemia

    Meconium Aspiration Syndrome

    • Pathophysiology:
      • Hypoxic stress causes passage of meconium in utero
      • Fetus ingest meconium into the lower airways
      • Air trapped due to obstruction of meconium
      • Hyperinflation distal to the obstruction lead to Atelectasis due to deactivation of surfactant (Hypoxemia, hyperinflation, acidemia)
    • Clinical manifestations:
      • Tachypnea, retractions, expiratory grunting
      • Nasal flaring
      • Cyanotic or pale
      • Barrel chest from hyperinflation
      • Stressed, hypothermic
      • Hypoglycemic and hypocalcemic
    • Diagnostic evaluation:
      • Laryngoscopy to visualize the respiratory passages and vocal cords
      • Chest radiographs show uneven distribution of patchy infiltrates, air trapping, hyper expansion, and atelectasis
      • Air leaks may occur as the illness progresses
    • Therapeutic management:
      • Tracheal suctioning based on infant assessment after birth
      • Administration of surfactant

    Respiratory Distress Syndrome

    • Treatment:
      • Administration of surfactant (Beractant, Poractant, Calfactant)
      • Complications: Pulmonary hemorrhage and mucus plugging
    • Nursing responsibilities:
      • Assist in the delivery of the product
      • Collect and monitor ABG
      • Monitor oxygenation
      • Assess infant's tolerance of the procedure
      • Surfactant absorption increases respiratory compliance, requiring adjustment of the ventilator
      • Suctioning delayed for an hour depending on the type of surfactant and delivery system

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    Description

    Test your knowledge on hyperbilirubinemia, its causes, and the associated physiological factors like prematurity and breastfeeding. Learn about the signs of complications such as meningitis and septic shock.

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